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Summary sheet information for Effector 'Rac-Homo sapiens-3'
Name Rac-Homo sapiens-3
Description RecName: Full=Ras-related C3 botulinum toxin substrate 3;AltName: Full=p21-Rac3;Flags: Precursor
Class
Family Small GTP-binding proteins
Sub_family Rho small GTPases
type Rac
Protein features link Protein Information from Dasty2 DAS Client
GPCR, G-protein, Effector interaction Visualizaton of GPCR, G-protein, Effector interaction at protein level
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Genes
Gene Location:
Chromosome: 17
Gene Start: 77582821
Gene End: 77585366
Ensembl Contig View

Ensembl Genes:
ENSG00000169750

EMBL:
EMBL ID  Description
AF008591  Homo sapiens Rac3 (RAC3) mRNA, complete cds.
AF498966  Homo sapiens small GTP binding protein RAC3 (RAC3) mRNA, complete cds.
BC009605  Homo sapiens ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3), mRNA (cDNA clone MGC:14757 IMAGE:4284122), complete cds.
BC015197  Homo sapiens ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3), mRNA (cDNA clone MGC:14729 IMAGE:4275237), complete cds.
BT019443  Homo sapiens ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) mRNA, complete cds.

EntrezGene:
ID  Description
RAC3  ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)

RefSeq DNA:
ID  Description
NM_005052  Homo sapiens ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) (RAC3), mRNA.

UniGene:
ID  Description

Proteins
Ensembl Proteins:
ENSP00000304283

Entrez Proteins:
AAC51667.1; AAH09605.1; AAH15197.1; AAM21113.1; AAV38250.1

RefSeq Proteins:
ID  Description
NP_005043  ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) [Homo sapiens].

UniProt:
ID  Description
P60763  RecName: Full=Ras-related C3 botulinum toxin substrate 3; AltName: Full=p21-Rac3; Flags: Precursor;

Domains
SMART:
- Hyperlink to SMART; - Hyperlink to ENSEMBL
     Rac-Homo sapiens-3    

InterPro:
ID  Name
IPR003578  GTPase_Rho
IPR005225  Small_GTP_bd
IPR001806  Ras_trnsfrmng
IPR013753  Ras

Pfam:
ID  Description
Ras  Ras family

Structure
PDB:
ID
2C2H
2G0N
2IC5
2OV2
2QME

HSSP:
ID  Description
1a2b  ONCOGENE PROTEIN
1a4r  HYDROLASE
1aje  G-PROTEIN
1am4  COMPLEX (GTPASE-ACTIVATING/GTP-BINDING)
1an0  GTPASE
1cc0  SIGNALING PROTEIN
1cee  STRUCTURAL PROTEIN REGULATION
1cf4  TRANSFERASE
1cxz  SIGNALING PROTEIN
1doa  CELL CYCLE
1dpf  GENE REGULATION/SIGNALING PROTEIN
1ds6  SIGNALING PROTEIN
1e0a  SIGNALLING PROTEIN
1e96  SIGNALLING COMPLEX
1ees  STRUCTURAL PROTEIN
1foe  SIGNALING PROTEIN, IMMUNE SYSTEM/SIGNALI
1ftn  PROTO-ONCOGENE
1g4u  SIGNALING PROTEIN
1grn  GENE REGULATION
1gwn  GTPASE
1gzs  COMPLEX (TOXIN/CELL CYCLE PROTEIN)
1he1  SIGNALLING COMPLEX
1hh4  SINGAL PROTEIN INHIBITOR COMPLEX
1i4d  SIGNALING PROTEIN
1i4l  SIGNALING PROTEIN
1i4t  SIGNALING PROTEIN
1ki1  SIGNALING PROTEIN
1kmq  SIGNALING PROTEIN
1kz7  SIGNALING PROTEIN
1kzg  SIGNALING PROTEIN
1lb1  SIGNALING PROTEIN
1m7b  SIGNALING PROTEIN
1mh1  GTP-BINDING
1nf3  SIGNALING PROTEIN
1ow3  GENE REGULATION/SIGNALING PROTEIN
1ryf  HYDROLASE
1ryh  HYDROLASE
1s1c  SIGNALING PROTEIN
1tx4  COMPLEX(GTPASE ACTIVATN/PROTO-ONCOGENE)
1x86  SIGNALING PROTEIN/MEMBRANE PROTEIN
1xcg  SIGNALING PROTEIN ACTIVATOR/SIGNALING PR
1z2c  SIGNALING PROTEIN
2ase  SIGNALING PROTEIN
2atx  HYDROLASE
2c2h  SIGNALING PROTEIN
2cls  NUCLEOTIDE BINDING PROTEIN
2dfk  CELL CYCLE
2fju  SIGNALING PROTEIN,APOPTOSIS/HYDROLASE
2fv8  SIGNALING PROTEIN
2g0n  SIGNALING PROTEIN
2gcn  SIGNALING PROTEIN
2gco  SIGNALING PROTEIN
2gcp  SIGNALING PROTEIN
2h7v  SIGNALING PROTEIN
2ic5  SIGNALING PROTEIN
2j0v  NUCLEOTIDE-BINDING PROTEIN
2j1l  HYDROLASE
2ngr  HYDROLASE
2nty  SIGNALING PROTEIN
2nz8  SIGNALING PROTEIN,CELL CYCLE
2odb  PROTEIN BINDING
2ov2  PROTEIN BINDING/TRANSFERASE
2p2l  UNKNOWN FUNCTION
2q3h  STRUCTURAL GENOMICS
2qme  SIGNALING PROTEIN/TRANSFERASE
2qrz  CELL CYCLE
2rex  SIGNALING PROTEIN/LIPOPROTEIN
2rgn  SIGNALING PROTEIN COMPLEX
2rmk  MEMBRANE PROTEIN/TRANSFERASE
2v55  TRANSFERASE
2vrw  SIGNALING PROTEIN
3bji  SIGNALING PROTEIN
3bwd  PLANT PROTEIN
3c5c  SIGNALING PROTEIN
3eg5  SIGNALING PROTEIN

PSSH:
ID  Description
P60763  UNKNOWN

Diseases
OMIM:
OMIM ID  Name  Alt Name
602050  RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3; RAC3   RHO FAMILY, SMALL GTP-BINDING PROTEIN RAC3

Gene Ontology
GO:
GO ID  Description
GO:0000166  nucleotide binding
GO:0003924  GTPase activity
GO:0005515  protein binding
GO:0005525  GTP binding
GO:0005622  intracellular
GO:0005737  cytoplasm
GO:0006813  potassium ion transport
GO:0006886  intracellular protein transport
GO:0006913  nucleocytoplasmic transport
GO:0007165  signal transduction
GO:0007264  small GTPase mediated signal transduction
GO:0008324  cation transmembrane transporter activity
GO:0012505  endomembrane system
GO:0015031  protein transport
GO:0016020  membrane
GO:0030031  cell projection assembly
GO:0030036  actin cytoskeleton organization
GO:0031175  neurite development
GO:0042995  cell projection
GO:0050885  neuromuscular process controlling balance
GO:0050905  neuromuscular process

Pathway
KEGG:
KEGG PATHWAY ID  Name
hsa04520  Adherens junction
hsa04360  Axon guidance
hsa04662  B cell receptor signaling pathway
hsa05210  Colorectal cancer
hsa04664  Fc epsilon RI signaling pathway
hsa04510  Focal adhesion
hsa04010  MAPK signaling pathway
hsa04650  Natural killer cell mediated cytotoxicity
hsa05212  Pancreatic cancer
hsa05200  Pathways in cancer
hsa04810  Regulation of actin cytoskeleton
hsa04370  VEGF signaling pathway
hsa05416  Viral myocarditis
hsa04310  Wnt signaling pathway

Panther:
ID  Description
P00008  Axon guidance mediated by Slit/Robo
P00010  B cell activation
P00053  T cell activation
P00007  Axon guidance mediated by semaphorins
P04393  Ras Pathway
P00018  EGF receptor signaling pathway
P00034  Integrin signalling pathway
P00021  FGF signaling pathway
P00009  Axon guidance mediated by netrin
P00016  Cytoskeletal regulation by Rho GTPase
P00029  Huntington disease

Chemicals
DrugBank:
ID  Name  Synonyms
HMDB:
ID  Name  Synonyms
Orthology
Orthology Relations:
Gene Gene Description Organism Orthology type Orthologs Orthologs Description
ENSG00000169750 Ras-related C3 botulinum toxin substrate 3 Precursor (p21-Rac3) [Source:UniProtKB/Swiss-Prot;Acc:P60763] Anopheles_gambiaeone2many AGAP005445[hgnc]AgaP_ENSANGG00000011739
Aedes_aegyptione2many AAEL009732rac GTPase[hgnc]
Ciona_intestinalismany2many ENSCING00000002335Rac4 protein [Source:RefSeq_peptide;Acc:NP_001027963][hgnc]448957
Tursiops_truncatusone2one ENSTTRG00000001578Ras-related C3 botulinum toxin substrate 3 Precursor (p21-Rac3) [Source:UniProtKB/Swiss-Prot;Acc:P60763][hgnc]
Macaca_mulattaone2one ENSMMUG00000010895Ras-related C3 botulinum toxin substrate 3 Precursor (p21-Rac3) [Source:UniProtKB/Swiss-Prot;Acc:P60763][hgnc]
Tarsius_syrichtaone2one ENSTSYG00000014772Ras-related C3 botulinum toxin substrate 3 Precursor (p21-Rac3) [Source:UniProtKB/Swiss-Prot;Acc:P60763][hgnc]
Cavia_porcellusone2one ENSCPOG00000013861Ras-related C3 botulinum toxin substrate 3 Precursor (p21-Rac3) [Source:UniProtKB/Swiss-Prot;Acc:P60763][hgnc]
Pongo_pygmaeusone2one ENSPPYG00000008763Ras-related C3 botulinum toxin substrate 3 Precursor (p21-Rac3) [Source:UniProtKB/Swiss-Prot;Acc:P60763][hgnc]
Bos_taurusone2one ENSBTAG00000022927MGC166020 protein. [Source:UniProtKB/TrEMBL;Acc:A5PK69][hgnc]RAC3
Otolemur_garnettiione2one ENSOGAG00000012467Ras-related C3 botulinum toxin substrate 3 Precursor (p21-Rac3) [Source:UniProtKB/Swiss-Prot;Acc:P60763][hgnc]
Felis_catusone2one ENSFCAG00000011671Ras-related C3 botulinum toxin substrate 3 Precursor (p21-Rac3) [Source:UniProtKB/Swiss-Prot;Acc:P60763][hgnc]
Equus_caballusone2one ENSECAG00000014115Ras-related C3 botulinum toxin substrate 3 Precursor (p21-Rac3) [Source:UniProtKB/Swiss-Prot;Acc:P60763][hgnc]
Mus_musculusone2one ENSMUSG00000018012Ras-related C3 botulinum toxin substrate 3 Precursor (p21-Rac3) [Source:UniProtKB/Swiss-Prot;Acc:P60764][hgnc]Rac3
Pteropus_vampyrusone2one ENSPVAG00000013285Ras-related C3 botulinum toxin substrate 3 Precursor (p21-Rac3) [Source:UniProtKB/Swiss-Prot;Acc:P60763][hgnc]
Echinops_telfairione2one ENSETEG00000012902Ras-related C3 botulinum toxin substrate 3 Precursor (p21-Rac3) [Source:UniProtKB/Swiss-Prot;Acc:P60763][hgnc]
Loxodonta_africanaone2one ENSLAFG00000011153Ras-related C3 botulinum toxin substrate 3 Precursor (p21-Rac3) [Source:UniProtKB/Swiss-Prot;Acc:P60763][hgnc]
Dipodomys_ordiione2one ENSDORG00000013521Ras-related C3 botulinum toxin substrate 3 Precursor (p21-Rac3) [Source:UniProtKB/Swiss-Prot;Acc:P60764][hgnc]
Procavia_capensisapprent_one2one ENSPCAG00000009949Ras-related C3 botulinum toxin substrate 3 Precursor (p21-Rac3) [Source:UniProtKB/Swiss-Prot;Acc:P60763][hgnc]
Monodelphis_domesticaone2one ENSMODG00000003244Ras-related C3 botulinum toxin substrate 3 Precursor (p21-Rac3) [Source:UniProtKB/Swiss-Prot;Acc:P60763][hgnc]
Gasterosteus_aculeatusapprent_one2one ENSGACG00000015393Ras-related C3 botulinum toxin substrate 3 Precursor (p21-Rac3) [Source:UniProtKB/Swiss-Prot;Acc:P60763][hgnc]
Gallus_gallusone2one ENSGALG00000002859ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) [Source:RefSeq_peptide;Acc:NP_990347][hgnc]RAC1
Takifugu_rubripesapprent_one2one ENSTRUG00000004543Ras-related C3 botulinum toxin substrate 3 Precursor (p21-Rac3) [Source:UniProtKB/Swiss-Prot;Acc:P60763][hgnc]
Microcebus_murinusapprent_one2one ENSMICG00000001114Ras-related C3 botulinum toxin substrate 3 Precursor (p21-Rac3) [Source:UniProtKB/Swiss-Prot;Acc:P60763][hgnc]
Oryzias_latipesapprent_one2one ENSORLG00000002677Ras-related C3 botulinum toxin substrate 3 Precursor (p21-Rac3) [Source:UniProtKB/Swiss-Prot;Acc:P60763][hgnc]
Tupaia_belangeriapprent_one2one ENSTBEG00000007272Ras-related C3 botulinum toxin substrate 3 Precursor (p21-Rac3) [Source:UniProtKB/Swiss-Prot;Acc:P60763][hgnc]
Danio_rerioone2one ENSDARG00000040651ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) [Source:RefSeq_peptide;Acc:NP_001002754][hgnc]rac3
Drosophila_melanogastermany2many FBgn0010333[hgnc]Rac1
Drosophila_melanogastermany2many FBgn0014011[hgnc]Rac2
Canis_familiarisapprent_one2one ENSCAFG00000005922Ras-related C3 botulinum toxin substrate 3 Precursor (p21-Rac3) [Source:UniProtKB/Swiss-Prot;Acc:P60763][hgnc]
Ciona_intestinalismany2many ENSCING00000002330Rac2 protein [Source:RefSeq_peptide;Acc:NP_001027787][hgnc]448954
Caenorhabditis_elegansmany2many C09G12.8ced-10 encodes a GTPase orthologous to human RAC1 (OMIM:602048) that is required for phagocytosis during programmed cell death and for migration of the distal tip cells of the somatic gonad. CED-10 functions in the engulfing cell during apoptosis, and is activated by a complex of CED-2(CrkII) and CED-5(DOCK180) to promote formation of the polarized cell extensions associated with cell corpse engulfment. [Source: WormBase][hgnc]ced-10
Ciona_intestinalismany2many ENSCING00000002350Rac1 protein [Source:RefSeq_peptide;Acc:NP_001027692][hgnc]445702
Caenorhabditis_elegansmany2many K03D3.10rac-2 encodes a small Rho family GTPase that, along with CED-10 and MIG-2, is one of three C. elegans Rac-related proteins. genetic studies indicate that rac-2 functions redundantly with mig-2 and ced-10 to regulate CAN and PDE axon pathfinding and CAN cell migration. in addition, rac-2 functions slightly redundant with mig-2 during distal tip cell movement and slightly redundant with ced-10 during cell-corpse phagocytosis. as unc-73 mutations enhance rac-2 defects in axon pathfinding and CAN cell migration, UNC-73/Trio is a likely candidate to act upstream of RAC-2 and positively regulate its GTPase activity in vivo. further, as UNC-115 activity is required to mediate the morphogenetic effects of constitutively active RAC-2(G12V), UNC-115, an actin-binding protein, is likely to be a downstream effector of RAC-2. GFP::RAC-2 reporters expressed in neurons and neuroblasts reveal localization at cell margins and the nerve ring, the latter suggesting that GFP::RAC-2 associates with the axonal plasma membrane. [Source: WormBase][hgnc]rac-2
Ciona_intestinalismany2many ENSCING00000002345Rac5 protein [Source:RefSeq_peptide;Acc:NP_001027789][hgnc]448958
Ciona_intestinalismany2many ENSCING00000002339Rac3b protein (EC 3.6.1.47) (Fragment). [Source:UniProtKB/TrEMBL;Acc:Q7YT76][hgnc]