Quick search:







Summary sheet information for Effector 'Lbc RhoGEF-Homo sapiens'
Name Lbc RhoGEF-Homo sapiens
Description RecName: Full=A-kinase anchor protein 13; Short=AKAP-13;AltName: Full=Protein kinase A-anchoring protein 13;AltName: Full=Breast cancer nuclear receptor-binding auxiliary protein;AltName: Full=Human thyroid-anchoring protein 31;AltName: Full=Guanine nucleotide exchange factor Lbc;AltName: Full=AKAP-Lbc;AltName: Full=P47;AltName: Full=Lymphoid blast crisis oncogene; Short=LBC oncogene;AltName: Full=Non-oncogenic Rho GTPase-specific GTP exchange factor
Class
Family Guanine nucleotide exchange factors
Sub_family RhoGEFs
type Lbc RhoGEF
Protein features link Protein Information from Dasty2 DAS Client
GPCR, G-protein, Effector interaction Visualizaton of GPCR, G-protein, Effector interaction at protein level
Expand All Collapse All
Genes
Gene Location:
Chromosome: 15
Gene Start: 83724875
Gene End: 84093590
Ensembl Contig View

Ensembl Genes:
ENSG00000170776

EMBL:
EMBL ID  Description
AB055890  Homo sapiens c-lbc mRNA for guanine nucleotide exchange factor Lbc, complete cds.
AB209414  Homo sapiens mRNA for A-kinase anchor protein 13 isoform 2 variant protein.
AC044860  Homo sapiens chromosome 15, clone RP11-561C5, complete sequence.
AF126008  Homo sapiens breast cancer nuclear receptor-binding auxiliary protein (BRX) mRNA, complete cds.
AF127481  Homo sapiens non-ocogenic Rho GTPase-specific GTP exchange factor (proto-LBC) mRNA, complete cds.
AF387101  Homo sapiens protein kinase A anchoring protein Ht31 mRNA, complete cds.
AF406992  Homo sapiens A-kinase anchoring protein mRNA, complete cds.
AK315885  Homo sapiens cDNA, FLJ79534 partial cds, highly similar to Homo sapiens A kinase (PRKA) anchor protein 13 (AKAP13).
BC050312  Homo sapiens A kinase (PRKA) anchor protein 13, mRNA (cDNA clone IMAGE:5263747), complete cds.
M90360  Human type II cAMP-dependent protein kinase (Ht31) mRNA, complete cds.
U03634  Human P47 LBC oncogene mRNA, complete cds.

EntrezGene:
ID  Description
AKAP13  A kinase (PRKA) anchor protein 13

RefSeq DNA:
ID  Description
NM_006738  Homo sapiens A kinase (PRKA) anchor protein 13 (AKAP13), transcript variant 1, mRNA.
NM_007200  Homo sapiens A kinase (PRKA) anchor protein 13 (AKAP13), transcript variant 2, mRNA.
NM_144767  Homo sapiens A kinase (PRKA) anchor protein 13 (AKAP13), transcript variant 3, mRNA.

UniGene:
ID  Description
Hs.459211  Type II cAMP-dependent protein kinase (Ht31)
Hs.608041  Transcribed locus
Hs.619023  Transcribed locus

Proteins
Ensembl Proteins:
ENSP00000378018; ENSP00000378024; ENSP00000378026; ENSP00000354718

Entrez Proteins:
AAA58670.1; AAC50065.1; AAD21311.1; AAD40799.1; AAH50312.1; AAL11723.1; AAL40923.1; BAB62913.1; BAD92651.1; BAF98776.1

RefSeq Proteins:
ID  Description
NP_006729  A-kinase anchor protein 13 isoform 1 [Homo sapiens].
NP_009131  A-kinase anchor protein 13 isoform 2 [Homo sapiens].
NP_658913  A-kinase anchor protein 13 isoform 3 [Homo sapiens].

UniProt:
ID  Description
Q12802-2  UNKNOWN
Q12802-3  UNKNOWN
Q12802-4  UNKNOWN
Q12802-5  UNKNOWN
Q12802-6  UNKNOWN
Q12802-7  UNKNOWN
A8MPW5  UNKNOWN
A8MVN0  SubName: Full=Putative uncharacterized protein AKAP13; Flags: Fragment;
A8MYJ1  SubName: Full=Putative uncharacterized protein AKAP13; Flags: Fragment;
B0AZU4  SubName: Full=cDNA, FLJ79534, highly similar to Homo sapiens A kinase (PRKA) anchor protein 13 (AKAP13); Flags: Fragment;
Q12802  RecName: Full=A-kinase anchor protein 13; Short=AKAP 13; AltName: Full=Protein kinase A-anchoring protein 13; AltName: Full=Breast cancer nuclear receptor-binding auxiliary protein; AltName: Full=Human thyroid-anchoring protein 31; AltName: Full=Guanine nucleotide exchange factor Lbc; AltName: Full=AKAP-Lbc; AltName: Full=P47; AltName: Full=Lymphoid blast crisis oncogene; Short=LBC oncogene; AltName: Full=Non-oncogenic Rho GTPase-specific GTP exchange factor;

Domains
SMART:
- Hyperlink to SMART; - Hyperlink to ENSEMBL
     Lbc RhoGEF-Homo sapiens    

InterPro:
ID  Name
IPR001849  Pleckstrin_homology
IPR002048  EF_hand_Ca_bd
IPR002219  DAG_PE_bd
IPR001331  GDS_CDC24_CS
IPR011993  PH_type
IPR015721  RhoGEF_like
IPR000219  DH-domain

Pfam:
ID  Description
C1_1  Phorbol esters/diacylglycerol binding domain (C1 domain)
PH  PH domain
RhoGEF  RhoGEF domain

Structure
PDB:
ID
2DRN

HSSP:
ID  Description
1txd  SIGNALING PROTEIN
1x86  SIGNALING PROTEIN/MEMBRANE PROTEIN
2drn  TRANSFERASE

PSSH:
ID  Description
Q12802  UNKNOWN

Diseases
OMIM:
OMIM ID  Name  Alt Name
604686  A-KINASE ANCHOR PROTEIN 13; AKAP13   HT31 LYMPHOID BLAST CRISIS ONCOGENE; LBC BRX

Gene Ontology
GO:
GO ID  Description
GO:0004691  cAMP-dependent protein kinase activity
GO:0004871  signal transducer activity
GO:0005085  guanyl-nucleotide exchange factor activity
GO:0005089  Rho guanyl-nucleotide exchange factor activity
GO:0005509  calcium ion binding
GO:0005515  protein binding
GO:0005575  cellular_component
GO:0005622  intracellular
GO:0005624  membrane fraction
GO:0005634  nucleus
GO:0005737  cytoplasm
GO:0007242  intracellular signaling cascade
GO:0008150  biological_process
GO:0008270  zinc ion binding
GO:0016020  membrane
GO:0016301  kinase activity
GO:0019992  diacylglycerol binding
GO:0035023  regulation of Rho protein signal transduction
GO:0046872  metal ion binding

Pathway
KEGG:
KEGG PATHWAY ID  Name

Panther:
ID  Description

Chemicals
DrugBank:
ID  Name  Synonyms
HMDB:
ID  Name  Synonyms
Orthology
Orthology Relations:
Gene Gene Description Organism Orthology type Orthologs Orthologs Description
ENSG00000170776 A-kinase anchor protein 13 (AKAP 13) (Protein kinase A-anchoring protein 13) (Breast cancer nuclear receptor-binding auxiliary protein) (Human thyroid-anchoring protein 31) [Source:UniProtKB/Swiss-Prot;Acc:Q12802] Otolemur_garnettiione2one ENSOGAG00000007724A-kinase anchor protein 13 (AKAP 13) (Protein kinase A-anchoring protein 13) (Breast cancer nuclear receptor-binding auxiliary protein) (Human thyroid-anchoring protein 31) [Source:UniProtKB/Swiss-Prot;Acc:Q12802][hgnc]
Dipodomys_ordiione2one ENSDORG00000013525[hgnc]
Loxodonta_africanaone2one ENSLAFG00000010529A-kinase anchor protein 13 (AKAP 13) (Protein kinase A-anchoring protein 13) (Breast cancer nuclear receptor-binding auxiliary protein) (Human thyroid-anchoring protein 31) [Source:UniProtKB/Swiss-Prot;Acc:Q12802][hgnc]
Microcebus_murinusone2one ENSMICG00000013618A-kinase anchor protein 13 (AKAP 13) (Protein kinase A-anchoring protein 13) (Breast cancer nuclear receptor-binding auxiliary protein) (Human thyroid-anchoring protein 31) [Source:UniProtKB/Swiss-Prot;Acc:Q12802][hgnc]
Tursiops_truncatusone2one ENSTTRG00000002800A-kinase anchor protein 13 (AKAP 13) (Protein kinase A-anchoring protein 13) (Breast cancer nuclear receptor-binding auxiliary protein) (Human thyroid-anchoring protein 31) [Source:UniProtKB/Swiss-Prot;Acc:Q12802][hgnc]
Rattus_norvegicusone2one ENSRNOG00000010964[hgnc]
Myotis_lucifugusone2one ENSMLUG00000008671A-kinase anchor protein 13 (AKAP 13) (Protein kinase A-anchoring protein 13) (Breast cancer nuclear receptor-binding auxiliary protein) (Human thyroid-anchoring protein 31) [Source:UniProtKB/Swiss-Prot;Acc:Q12802][hgnc]
Vicugna_pacosone2one ENSVPAG00000009549A-kinase anchor protein 13 (AKAP 13) (Protein kinase A-anchoring protein 13) (Breast cancer nuclear receptor-binding auxiliary protein) (Human thyroid-anchoring protein 31) [Source:UniProtKB/Swiss-Prot;Acc:Q12802][hgnc]
Tarsius_syrichtaone2one ENSTSYG00000011967A-kinase anchor protein 13 (AKAP 13) (Protein kinase A-anchoring protein 13) (Breast cancer nuclear receptor-binding auxiliary protein) (Human thyroid-anchoring protein 31) [Source:UniProtKB/Swiss-Prot;Acc:Q12802][hgnc]
Cavia_porcellusone2one ENSCPOG00000013090A-kinase anchor protein 13 (AKAP 13) (Protein kinase A-anchoring protein 13) (Breast cancer nuclear receptor-binding auxiliary protein) (Human thyroid-anchoring protein 31) [Source:UniProtKB/Swiss-Prot;Acc:Q12802][hgnc]
Canis_familiarisone2one ENSCAFG00000011376A-kinase anchor protein 13 (AKAP 13) (Protein kinase A-anchoring protein 13) (Breast cancer nuclear receptor-binding auxiliary protein) (Human thyroid-anchoring protein 31) [Source:UniProtKB/Swiss-Prot;Acc:Q12802][hgnc]AKAP13
Macaca_mulattaone2one ENSMMUG00000011251A-kinase anchor protein 13 (AKAP 13) (Protein kinase A-anchoring protein 13) (Breast cancer nuclear receptor-binding auxiliary protein) (Human thyroid-anchoring protein 31) [Source:UniProtKB/Swiss-Prot;Acc:Q12802][hgnc]
Pongo_pygmaeusone2one ENSPPYG00000006745A-kinase anchor protein 13 (AKAP 13) (Protein kinase A-anchoring protein 13) (Breast cancer nuclear receptor-binding auxiliary protein) (Human thyroid-anchoring protein 31) [Source:UniProtKB/Swiss-Prot;Acc:Q12802][hgnc]
Pan_troglodytesone2one ENSPTRG00000007414A-kinase anchor protein 13 (AKAP 13) (Protein kinase A-anchoring protein 13) (Breast cancer nuclear receptor-binding auxiliary protein) (Human thyroid-anchoring protein 31) [Source:UniProtKB/Swiss-Prot;Acc:Q12802][hgnc]AKAP13
Tupaia_belangerione2one ENSTBEG00000000914A-kinase anchor protein 13 (AKAP 13) (Protein kinase A-anchoring protein 13) (Breast cancer nuclear receptor-binding auxiliary protein) (Human thyroid-anchoring protein 31) [Source:UniProtKB/Swiss-Prot;Acc:Q12802][hgnc]
Danio_rerioone2many ENSDARG00000051709[hgnc]LOC556697
Ornithorhynchus_anatinusone2one ENSOANG00000003588A-kinase anchor protein 13 (AKAP 13) (Protein kinase A-anchoring protein 13) (Breast cancer nuclear receptor-binding auxiliary protein) (Human thyroid-anchoring protein 31) [Source:UniProtKB/Swiss-Prot;Acc:Q12802][hgnc]100078722
Equus_caballusone2one ENSECAG00000009706A-kinase anchor protein 13 (AKAP 13) (Protein kinase A-anchoring protein 13) (Breast cancer nuclear receptor-binding auxiliary protein) (Human thyroid-anchoring protein 31) [Source:UniProtKB/Swiss-Prot;Acc:Q12802][hgnc]
Xenopus_tropicalisone2one ENSXETG00000007623A-kinase anchor protein 13 (AKAP 13) (Protein kinase A-anchoring protein 13) (Breast cancer nuclear receptor-binding auxiliary protein) (Human thyroid-anchoring protein 31) [Source:UniProtKB/Swiss-Prot;Acc:Q12802][hgnc]
Takifugu_rubripesone2one ENSTRUG00000015155A-kinase anchor protein 13 (AKAP 13) (Protein kinase A-anchoring protein 13) (Breast cancer nuclear receptor-binding auxiliary protein) (Human thyroid-anchoring protein 31) [Source:UniProtKB/Swiss-Prot;Acc:Q12802][hgnc]
Pteropus_vampyrusone2one ENSPVAG00000006089A-kinase anchor protein 13 (AKAP 13) (Protein kinase A-anchoring protein 13) (Breast cancer nuclear receptor-binding auxiliary protein) (Human thyroid-anchoring protein 31) [Source:UniProtKB/Swiss-Prot;Acc:Q12802][hgnc]
Echinops_telfairione2one ENSETEG00000000522A-kinase anchor protein 13 (AKAP 13) (Protein kinase A-anchoring protein 13) (Breast cancer nuclear receptor-binding auxiliary protein) (Human thyroid-anchoring protein 31) [Source:UniProtKB/Swiss-Prot;Acc:Q12802][hgnc]
Tetraodon_nigroviridisone2one ENSTNIG00000011914A-kinase anchor protein 13 (AKAP 13) (Protein kinase A-anchoring protein 13) (Breast cancer nuclear receptor-binding auxiliary protein) (Human thyroid-anchoring protein 31) [Source:UniProtKB/Swiss-Prot;Acc:Q12802][hgnc]
Procavia_capensisone2one ENSPCAG00000010443A-kinase anchor protein 13 (AKAP 13) (Protein kinase A-anchoring protein 13) (Breast cancer nuclear receptor-binding auxiliary protein) (Human thyroid-anchoring protein 31) [Source:UniProtKB/Swiss-Prot;Acc:Q12802][hgnc]
Oryzias_latipesone2one ENSORLG00000014616A-kinase anchor protein 13 (AKAP 13) (Protein kinase A-anchoring protein 13) (Breast cancer nuclear receptor-binding auxiliary protein) (Human thyroid-anchoring protein 31) [Source:UniProtKB/Swiss-Prot;Acc:Q12802][hgnc]
Spermophilus_tridecemlineatusone2one ENSSTOG00000007371A-kinase anchor protein 13 (AKAP 13) (Protein kinase A-anchoring protein 13) (Breast cancer nuclear receptor-binding auxiliary protein) (Human thyroid-anchoring protein 31) [Source:UniProtKB/Swiss-Prot;Acc:Q12802][hgnc]
Gasterosteus_aculeatusone2many ENSGACG00000014778A-kinase anchor protein 13 (AKAP 13) (Protein kinase A-anchoring protein 13) (Breast cancer nuclear receptor-binding auxiliary protein) (Human thyroid-anchoring protein 31) [Source:UniProtKB/Swiss-Prot;Acc:Q12802][hgnc]
Gasterosteus_aculeatusone2many ENSGACG00000000625A-kinase anchor protein 13 (AKAP 13) (Protein kinase A-anchoring protein 13) (Breast cancer nuclear receptor-binding auxiliary protein) (Human thyroid-anchoring protein 31) [Source:UniProtKB/Swiss-Prot;Acc:Q12802][hgnc]
Danio_rerioone2many ENSDARG00000023868A-kinase anchor protein 13 (AKAP 13) (Protein kinase A-anchoring protein 13) (Breast cancer nuclear receptor-binding auxiliary protein) (Human thyroid-anchoring protein 31) [Source:UniProtKB/Swiss-Prot;Acc:Q12802][hgnc]
Gallus_gallusone2one ENSGALG00000006840A-kinase anchor protein 13 (AKAP 13) (Protein kinase A-anchoring protein 13) (Breast cancer nuclear receptor-binding auxiliary protein) (Human thyroid-anchoring protein 31) [Source:UniProtKB/Swiss-Prot;Acc:Q12802][hgnc]
Oryctolagus_cuniculusone2one ENSOCUG00000011649A-kinase anchor protein 13 (AKAP 13) (Protein kinase A-anchoring protein 13) (Breast cancer nuclear receptor-binding auxiliary protein) (Human thyroid-anchoring protein 31) [Source:UniProtKB/Swiss-Prot;Acc:Q12802][hgnc]
Monodelphis_domesticaone2one ENSMODG00000013360A-kinase anchor protein 13 (AKAP 13) (Protein kinase A-anchoring protein 13) (Breast cancer nuclear receptor-binding auxiliary protein) (Human thyroid-anchoring protein 31) [Source:UniProtKB/Swiss-Prot;Acc:Q12802][hgnc]
Erinaceus_europaeusone2one ENSEEUG00000000694A-kinase anchor protein 13 (AKAP 13) (Protein kinase A-anchoring protein 13) (Breast cancer nuclear receptor-binding auxiliary protein) (Human thyroid-anchoring protein 31) [Source:UniProtKB/Swiss-Prot;Acc:Q12802][hgnc]
Ochotona_princepsone2one ENSOPRG00000017134A-kinase anchor protein 13 (AKAP 13) (Protein kinase A-anchoring protein 13) (Breast cancer nuclear receptor-binding auxiliary protein) (Human thyroid-anchoring protein 31) [Source:UniProtKB/Swiss-Prot;Acc:Q12802][hgnc]
Bos_taurusone2many ENSBTAG00000021064[hgnc]
Sorex_araneusone2one ENSSARG00000002015A-kinase anchor protein 13 (AKAP 13) (Protein kinase A-anchoring protein 13) (Breast cancer nuclear receptor-binding auxiliary protein) (Human thyroid-anchoring protein 31) [Source:UniProtKB/Swiss-Prot;Acc:Q12802][hgnc]
Bos_taurusone2many ENSBTAG00000033915[hgnc]
Ciona_intestinalisone2many ENSCING00000007425[hgnc]
Ciona_savignyione2many ENSCSAVG00000003345[hgnc]