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Summary sheet information for GPCR 'GLYCOPROTEIN HORMONE RECEPTORS_FSH_Homo sapiens'
Name GLYCOPROTEIN HORMONE RECEPTORS_FSH_Homo sapiens
Description RecName: Full=Follicle-stimulating hormone receptor; Short=FSH-R;AltName: Full=Follitropin receptor;Flags: Precursor
Class CLASS A
Family GLYCOPROTEIN HORMONE RECEPTORS
Sub_family FSH
type
Protein features link Protein Information from Dasty2 DAS Client
GPCR, G-protein, Effector interaction Visualizaton of GPCR, G-protein, Effector interaction at protein level
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Genes
Gene Location:
Chromosome: 2
Gene Start: 49042902
Gene End: 49235138
Ensembl Contig View

Ensembl Genes:
ENSG00000170820

EMBL:
EMBL ID  Description
AC079394  Homo sapiens BAC clone RP11-125F24 from 2, complete sequence.
AC092533  Homo sapiens BAC clone RP11-57I10 from 2, complete sequence.
AK292562  Homo sapiens cDNA FLJ76455 complete cds, highly similar to Homo sapiens follicle stimulating hormone receptor (FSHR), transcript variant 1, mRNA.
AY429104  Homo sapiens follicle stimulating hormone receptor mRNA, complete cds.
BC096831  Homo sapiens follicle stimulating hormone receptor, mRNA (cDNA clone MGC:111705 IMAGE:7001973), complete cds.
BC118548  Homo sapiens follicle stimulating hormone receptor, mRNA (cDNA clone MGC:141668 IMAGE:40007014), complete cds.
BC125270  Homo sapiens follicle stimulating hormone receptor, mRNA (cDNA clone MGC:141667 IMAGE:40007010), complete cds.
EF560624  Homo sapiens FSH receptor gene, exon 10 and partial cds.
M65085  Human follicle stimulating hormone receptor mRNA, complete cds.
M95489  H.sapiens follicle stimulating hormone receptor mRNA, complete cds.
S59900  follicle stimulating hormone receptor [human, testis, mRNA, 2179 nt].
S73199  follicle-stimulating hormone receptor {5' region} [human, Genomic, 1724 nt].
S73526  follicle-stimulating hormone receptor {exon 10} [human, Genomic, 1449 nt].
X68044  H.sapiens mRNA for follicle-stimulating hormone receptor

EntrezGene:
ID  Description
FSHR  follicle stimulating hormone receptor

RefSeq DNA:
ID  Description
NM_000145  Homo sapiens follicle stimulating hormone receptor (FSHR), transcript variant 1, mRNA.
NM_181446  Homo sapiens follicle stimulating hormone receptor (FSHR), transcript variant 2, mRNA.

UniGene:
ID  Description
Hs.1428  Follicle stimulating hormone receptor [human, testis, mRNA, 2179 nt]

Proteins
Ensembl Proteins:
ENSP00000306780; ENSP00000333908; ENSP00000384708

Entrez Proteins:
AAA52477.1; AAA52478.1; AAB26480.1; AAB32071.1; AAB32225.1; AAH96831.1; AAI18549.1; AAI25271.1; AAR07899.1; AAX88895.1; AAX93229.1; ABQ52449.1; BAF85251.1; CAA48179.1

RefSeq Proteins:
ID  Description
NP_000136  follicle stimulating hormone receptor isoform 1 precursor [Homo sapiens].
NP_852111  follicle stimulating hormone receptor isoform 2 precursor [Homo sapiens].

UniProt:
ID  Description
P23945-2  UNKNOWN
A5JS81  SubName: Full=FSH receptor; Flags: Fragment;
A8K947  UNKNOWN
Q05AH0  SubName: Full=FSHR protein;
Q4ZFZ2  SubName: Full=Putative uncharacterized protein FSHR; Flags: Fragment;
Q53RW2  SubName: Full=Putative uncharacterized protein FSHR; Flags: Fragment;
P23945  RecName: Full=Follicle-stimulating hormone receptor; Short=FSH-R; AltName: Full=Follitropin receptor; Flags: Precursor;

Domains
SMART:
- Hyperlink to SMART; - Hyperlink to ENSEMBL

InterPro:
ID  Name
IPR000372  LRR_cys_N
IPR002131  Gphrmn_rcpt
IPR000276  GPCR_Rhodpsn
IPR001611  LRR
IPR002272  FSH_rcpt
IPR017452  GPCR_Rhodpsn_supfam

Pfam:
ID  Description
7tm_1  7 transmembrane receptor (rhodopsin family)
LRR_1  Leucine Rich Repeat
LRR_1  Leucine Rich Repeat
LRRNT  Leucine rich repeat N-terminal domain

Structure
PDB:
ID
1XUN
1XWD

HSSP:
ID  Description
1xwd  HORMONE/GROWTH FACTOR

PSSH:
ID  Description
Q53RW2  UNKNOWN
P23945  UNKNOWN
Q05AH0  UNKNOWN

Diseases
OMIM:
OMIM ID  Name  Alt Name
136435  FOLLICLE-STIMULATING HORMONE RECEPTOR; FSHR   FSH RECEPTOR

Gene Ontology
GO:
GO ID  Description
GO:0001584  rhodopsin-like receptor activity
GO:0004872  receptor activity
GO:0004963  follicle-stimulating hormone receptor activity
GO:0004964  lutropin-choriogonadotropic hormone receptor activity
GO:0004983  neuropeptide Y receptor activity
GO:0005515  protein binding
GO:0005886  plasma membrane
GO:0007165  signal transduction
GO:0007186  G-protein coupled receptor protein signaling pathway
GO:0007283  spermatogenesis
GO:0007292  female gamete generation
GO:0008585  female gonad development
GO:0016021  integral to membrane
GO:0016500  protein-hormone receptor activity

Pathway
KEGG:
KEGG PATHWAY ID  Name
hsa04080  Neuroactive ligand-receptor interaction

Panther:
ID  Description

Chemicals
DrugBank:
ID  Name  Synonyms
DB00094  Urofollitropin  FSH-B; FSH-beta; Follicle-stimulating hormone beta subunit; Follitropin beta chain precursor
DB00066  Follitropin beta  FSH-B; FSH-beta; Follicle-stimulating hormone beta subunit; Follitropin alfa/beta; Follitropin beta chain precursor
DB00032  Menotropins  LH-B; LSH- beta; LSH-B; Luteinizing hormone beta subunit; Lutropin beta chain precursor
DB00097  Choriogonadotropin alfa  CG-beta; Choriogonadotropin beta chain precursor; Chorionic gonadotrophin beta subunit
HMDB:
ID  Name  Synonyms
Other GPCR resources
Links to other GPCR resources
GPCRDB | GPCR-OKB | GLIDA
Orthology
Orthology Relations:
Gene Gene Description Organism Orthology type Orthologs Orthologs Description
ENSG00000170820 Follicle-stimulating hormone receptor Precursor (FSH-R) (Follitropin receptor) [Source:UniProtKB/Swiss-Prot;Acc:P23945] Pan_troglodytesone2one ENSPTRG00000011914Follicle-stimulating hormone receptor Precursor (FSH-R) (Follitropin receptor) [Source:UniProtKB/Swiss-Prot;Acc:P23945][hgnc]FSHR
Pongo_pygmaeusone2one ENSPPYG00000012418Follicle-stimulating hormone receptor Precursor (FSH-R) (Follitropin receptor) [Source:UniProtKB/Swiss-Prot;Acc:P23945][hgnc]
Macaca_mulattaone2one ENSMMUG00000017196Follicle-stimulating hormone receptor Precursor (FSH-R) (Follitropin receptor) [Source:UniProtKB/Swiss-Prot;Acc:P23945][hgnc]
Tarsius_syrichtaone2one ENSTSYG00000002861Follicle-stimulating hormone receptor Precursor (FSH-R) (Follitropin receptor) [Source:UniProtKB/Swiss-Prot;Acc:P23945][hgnc]
Microcebus_murinusone2one ENSMICG00000006050Follicle-stimulating hormone receptor Precursor (FSH-R) (Follitropin receptor) [Source:UniProtKB/Swiss-Prot;Acc:P23945][hgnc]
Otolemur_garnettiione2one ENSOGAG00000009698Follicle-stimulating hormone receptor Precursor (FSH-R) (Follitropin receptor) [Source:UniProtKB/Swiss-Prot;Acc:P23945][hgnc]
Spermophilus_tridecemlineatusone2one ENSSTOG00000010396Follicle-stimulating hormone receptor Precursor (FSH-R) (Follitropin receptor) [Source:UniProtKB/Swiss-Prot;Acc:P23945][hgnc]
Equus_caballusone2one ENSECAG00000012303Follicle-stimulating hormone receptor precursor (FSH-R) (Follitropin receptor). [Source:UniProtKB/Swiss-Prot;Acc:P47799][hgnc]LOC100052957
Pteropus_vampyrusone2one ENSPVAG00000001411Follicle-stimulating hormone receptor Precursor (FSH-R) (Follitropin receptor) [Source:UniProtKB/Swiss-Prot;Acc:P23945][hgnc]
Dasypus_novemcinctusone2one ENSDNOG00000003464Follicle-stimulating hormone receptor Precursor (FSH-R) (Follitropin receptor) [Source:UniProtKB/Swiss-Prot;Acc:P23945][hgnc]
Canis_familiarisone2one ENSCAFG00000002698Follicle-stimulating hormone receptor Precursor (FSH-R) (Follitropin receptor) [Source:UniProtKB/Swiss-Prot;Acc:P23945][hgnc]FSHR
Vicugna_pacosone2one ENSVPAG00000002207Follicle-stimulating hormone receptor Precursor (FSH-R) (Follitropin receptor) [Source:UniProtKB/Swiss-Prot;Acc:P23945][hgnc]
Oryctolagus_cuniculusone2one ENSOCUG00000011234Follicle-stimulating hormone receptor Precursor (FSH-R) (Follitropin receptor) [Source:UniProtKB/Swiss-Prot;Acc:P23945][hgnc]
Bos_taurusone2many ENSBTAG00000012993Follicle stimulating hormone receptor (Fragment). [Source:UniProtKB/TrEMBL;Acc:A8DB93][hgnc]FSHR
Bos_taurusone2many ENSBTAG00000032424Follicle-stimulating hormone receptor precursor (FSH-R) (Follitropin receptor). [Source:UniProtKB/Swiss-Prot;Acc:P35376][hgnc]FSHR
Loxodonta_africanaone2one ENSLAFG00000017106Follicle-stimulating hormone receptor Precursor (FSH-R) (Follitropin receptor) [Source:UniProtKB/Swiss-Prot;Acc:P23945][hgnc]
Myotis_lucifugusone2one ENSMLUG00000007827Follicle-stimulating hormone receptor Precursor (FSH-R) (Follitropin receptor) [Source:UniProtKB/Swiss-Prot;Acc:P23945][hgnc]
Felis_catusone2one ENSFCAG00000001215Follicle-stimulating hormone receptor Precursor (FSH-R) (Follitropin receptor) [Source:UniProtKB/Swiss-Prot;Acc:P23945][hgnc]
Tursiops_truncatusone2one ENSTTRG00000003462Follicle-stimulating hormone receptor Precursor (FSH-R) (Follitropin receptor) [Source:UniProtKB/Swiss-Prot;Acc:P23945][hgnc]
Ochotona_princepsone2one ENSOPRG00000012970Follicle-stimulating hormone receptor Precursor (FSH-R) (Follitropin receptor) [Source:UniProtKB/Swiss-Prot;Acc:P23945][hgnc]
Cavia_porcellusone2one ENSCPOG00000011752Follicle-stimulating hormone receptor precursor (FSH-R) (Follitropin receptor). [Source:UniProtKB/Swiss-Prot;Acc:Q8R428][hgnc]
Dipodomys_ordiione2one ENSDORG00000006417Follicle-stimulating hormone receptor Precursor (FSH-R) (Follitropin receptor) [Source:UniProtKB/Swiss-Prot;Acc:P35378][hgnc]
Procavia_capensisone2one ENSPCAG00000013058Follicle-stimulating hormone receptor Precursor (FSH-R) (Follitropin receptor) [Source:UniProtKB/Swiss-Prot;Acc:P23945][hgnc]
Rattus_norvegicusone2one ENSRNOG00000016783Follicle-stimulating hormone receptor precursor (FSH-R) (Follitropin receptor). [Source:UniProtKB/Swiss-Prot;Acc:P20395][hgnc]Fshr
Sorex_araneusone2one ENSSARG00000011306Follicle-stimulating hormone receptor Precursor (FSH-R) (Follitropin receptor) [Source:UniProtKB/Swiss-Prot;Acc:P23945][hgnc]
Mus_musculusone2one ENSMUSG00000032937Follicle-stimulating hormone receptor Precursor (FSH-R) (Follitropin receptor) [Source:UniProtKB/Swiss-Prot;Acc:P35378][hgnc]Fshr
Echinops_telfairione2one ENSETEG00000016895Follicle-stimulating hormone receptor Precursor (FSH-R) (Follitropin receptor) [Source:UniProtKB/Swiss-Prot;Acc:P23945][hgnc]
Erinaceus_europaeusone2one ENSEEUG00000015800Follicle-stimulating hormone receptor Precursor (FSH-R) (Follitropin receptor) [Source:UniProtKB/Swiss-Prot;Acc:P23945][hgnc]
Monodelphis_domesticaone2one ENSMODG00000001267Follicle-stimulating hormone receptor Precursor (FSH-R) (Follitropin receptor) [Source:UniProtKB/Swiss-Prot;Acc:P23945][hgnc]
Gallus_gallusone2one ENSGALG00000009100Follicle-stimulating hormone receptor precursor (FSH-R) (Follitropin receptor). [Source:UniProtKB/Swiss-Prot;Acc:P79763][hgnc]FSHR
Xenopus_tropicalisone2one ENSXETG00000025827Follicle-stimulating hormone receptor Precursor (FSH-R) (Follitropin receptor) [Source:UniProtKB/Swiss-Prot;Acc:P23945][hgnc]
Danio_rerioone2one ENSDARG00000071494follicle stimulating hormone receptor [Source:RefSeq_peptide;Acc:NP_001001812][hgnc]LOC100002306
Gasterosteus_aculeatusone2one ENSGACG00000002728Follicle-stimulating hormone receptor Precursor (FSH-R) (Follitropin receptor) [Source:UniProtKB/Swiss-Prot;Acc:P23945][hgnc]
Tetraodon_nigroviridisone2one ENSTNIG00000003601Follicle-stimulating hormone receptor Precursor (FSH-R) (Follitropin receptor) [Source:UniProtKB/Swiss-Prot;Acc:P23945][hgnc]
Oryzias_latipesone2one ENSORLG00000010178Follicle-stimulating hormone receptor Precursor (FSH-R) (Follitropin receptor) [Source:UniProtKB/Swiss-Prot;Acc:P23945][hgnc]