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Summary sheet information for G-protein 'Gbeta-2_Homo sapiens'
Name Gbeta-2_Homo sapiens
Description RecName: Full=Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2;AltName: Full=Transducin beta chain 2;AltName: Full=G protein subunit beta-2
Class Gbeta
Family Gbeta
Sub_family Gbeta
type Gbeta-2
Protein features link Protein Information from Dasty2 DAS Client
GPCR, G-protein, Effector interaction Visualizaton of GPCR, G-protein, Effector interaction at protein level
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Genes
Gene Location:
Chromosome: 7
Gene Start: 100109311
Gene End: 100114733
Ensembl Contig View

Ensembl Genes:
ENSG00000172354

EMBL:
EMBL ID  Description
AF053356  Homo sapiens chromosome 7q22 sequence, complete sequence.
AF501883  Homo sapiens guanine nucleotide binding protein beta 2 (GNB2) mRNA, complete cds.
AK291592  Homo sapiens cDNA FLJ77321 complete cds, highly similar to Homo sapiens guanine nucleotide binding protein (G protein), beta polypeptide 2 (GNB2), mRNA.
BC010073  Homo sapiens guanine nucleotide binding protein (G protein), beta polypeptide 2, mRNA (cDNA clone MGC:19573 IMAGE:4300639), complete cds.
BC012348  Homo sapiens guanine nucleotide binding protein (G protein), beta polypeptide 2, mRNA (cDNA clone MGC:20143 IMAGE:4556119), complete cds.
BC068003  Homo sapiens guanine nucleotide binding protein (G protein), beta polypeptide 2, mRNA (cDNA clone MGC:70586 IMAGE:6055863), complete cds.
CH471091  Homo sapiens 211000035835468 genomic scaffold, whole genome shotgun sequence.
CR541729  Homo sapiens full open reading frame cDNA clone RZPDo834A1129D for gene GNB2, guanine nucleotide binding protein (G protein), beta polypeptide 2; complete cds, incl. stopcodon.
M16514  Human guanine nucleotide-binding regulatory protein (G protein) gene, 3' end.
M16538  Human signal-transducing guanine nucleotide-binding regulatory (G) protein beta subunit mRNA, complete cds.
M36429  Human transducin beta-2 subunit mRNA, complete cds.

EntrezGene:
ID  Description
GNB2  guanine nucleotide binding protein (G protein), beta polypeptide 2

RefSeq DNA:
ID  Description
NM_005273  Homo sapiens guanine nucleotide binding protein (G protein), beta polypeptide 2 (GNB2), mRNA.

UniGene:
ID  Description
Hs.702548  Transcribed locus, moderately similar to NP_001013515.1 guanine nucleotide binding protein (G protein), beta polypeptide 2 [Danio rerio]

Proteins
Ensembl Proteins:
ENSP00000377501; ENSP00000377503; ENSP00000305260

Entrez Proteins:
AAA03179.1; AAA35922.1; AAA63264.1; AAC78794.1; AAH10073.1; AAH12348.1; AAH68003.1; AAM15919.1; BAF84281.1; CAG46530.1; EAW76499.1

RefSeq Proteins:
ID  Description
NP_005264  guanine nucleotide-binding protein, beta-2 subunit [Homo sapiens].

UniProt:
ID  Description
Q6FHM2  SubName: Full=GNB2 protein; SubName: Full=cDNA FLJ77321, highly similar to Homo sapiens guanine nucleotide binding protein (G protein), beta polypeptide 2 (GNB2), mRNA; SubName: Full=Guanine nucleotide binding protein (G protein), beta polypeptide 2, isoform CRA_a;
P62879  RecName: Full=Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2; AltName: Full=Transducin beta chain 2; AltName: Full=G protein subunit beta-2;

Domains
SMART:
- Hyperlink to SMART; - Hyperlink to ENSEMBL

InterPro:
ID  Name
IPR001632  Gprotein_B
IPR001680  WD40_repeat
IPR016346  Guanine_nucleotide-bd_bsu
IPR015943  WD40/YVTN_repeat-like
IPR017986  WD40_repeat_region

Pfam:
ID  Description
WD40  WD domain, G-beta repeat

Structure
PDB:
ID

HSSP:
ID  Description
1a0r  COMPLEX (TRANSDUCER/TRANSDUCTION)
1b9x  SIGNALING PROTEIN
1b9y  SIGNALING PROTEIN
1erj  TRANSCRIPTION INHIBITOR
1gg2  COMPLEX (GTP-BINDING/TRANSDUCER)
1got  COMPLEX (GTP-BINDING/TRANSDUCER)
1gp2  COMPLEX (GTP-BINDING/TRANSDUCER)
1omw  TRANSFERASE
1sq9  ANTIVIRAL PROTEIN, RECOMBINATION
1tbg  COMPLEX (GTP-BINDING/TRANSDUCER)
1xhm  SIGNALING PROTEIN
2bcj  TRANSFERASE/HYDROLASE
2pbi  SIGNALING PROTEIN
2qns  SIGNALING PROTEIN
2trc  COMPLEX (TRANSDUCER/TRANSDUCTION)

PSSH:
ID  Description
Q6FHM2  UNKNOWN

Diseases
OMIM:
OMIM ID  Name  Alt Name
139390  GUANINE NUCLEOTIDE-BINDING PROTEIN, BETA-2; GNB2   UNKNOWN

Gene Ontology
GO:
GO ID  Description
GO:0003924  GTPase activity
GO:0004871  signal transducer activity
GO:0005246  calcium channel regulator activity
GO:0007165  signal transduction
GO:0007186  G-protein coupled receptor protein signaling pathway
GO:0009755  hormone-mediated signaling

Pathway
KEGG:
KEGG PATHWAY ID  Name
hsa04062  Chemokine signaling pathway

Panther:
ID  Description
P05911  Angiotensin II-stimulated signaling through G proteins and beta-arrestin
P05916  Opioid prodynorphin pathway
P00048  PI3 kinase pathway
P00039  Metabotropic glutamate receptor group III pathway
P00026  Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
P00042  Muscarinic acetylcholine receptor 1 and 3 signaling pathway
P05730  Endogenous cannabinoid signaling
P05731  GABA-B receptor II signaling
P04394  Thyrotropin-releasing hormone receptor signaling pathway
P04379  Beta3 adrenergic receptor signaling pathway
P04376  5HT4 type receptor mediated signaling pathway
P04386  Histamine H2 receptor mediated signaling pathway
P05912  Dopamine receptor mediated signaling pathway
P00057  Wnt signaling pathway
P04380  Cortocotropin releasing factor receptor signaling pathway
P04385  Histamine H1 receptor mediated signaling pathway
P00040  Metabotropic glutamate receptor group II pathway
P04377  Beta1 adrenergic receptor signaling pathway
P00043  Muscarinic acetylcholine receptor 2 and 4 signaling pathway
P00028  Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction
P04378  Beta2 adrenergic receptor signaling pathway
P05913  Enkephalin release
P04374  5HT2 type receptor mediated signaling pathway
P04373  5HT1 type receptor mediated signaling pathway
P05915  Opioid proenkephalin pathway
P05917  Opioid proopiomelanocortin pathway
P00027  Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
P04391  Oxytocin receptor mediated signaling pathway

Chemicals
DrugBank:
ID  Name  Synonyms
HMDB:
ID  Name  Synonyms
Orthology
Orthology Relations:
Gene Gene Description Organism Orthology type Orthologs Orthologs Description
ENSG00000172354 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 (Transducin beta chain 2) (G protein subunit beta-2) [Source:UniProtKB/Swiss-Prot;Acc:P62879] Pan_troglodytesone2one ENSPTRG00000019501Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 (Transducin beta chain 2) (G protein subunit beta-2) [Source:UniProtKB/Swiss-Prot;Acc:P62879][hgnc]GNB2
Pongo_pygmaeusone2one ENSPPYG00000017424Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 (Transducin beta chain 2) (G protein subunit beta-2) [Source:UniProtKB/Swiss-Prot;Acc:P62879][hgnc]
Macaca_mulattaone2one ENSMMUG00000004080Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 (Transducin beta chain 2) (G protein subunit beta-2) [Source:UniProtKB/Swiss-Prot;Acc:P62879][hgnc]
Equus_caballusone2one ENSECAG00000017221Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 (Transducin beta chain 2) (G protein subunit beta-2) [Source:UniProtKB/Swiss-Prot;Acc:P62879][hgnc]LOC100067486
Tursiops_truncatusone2one ENSTTRG00000006166Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 (Transducin beta chain 2) (G protein subunit beta-2) [Source:UniProtKB/Swiss-Prot;Acc:P62879][hgnc]
Canis_familiarisone2one ENSCAFG00000014282Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 (Transducin beta chain 2) (G protein subunit beta-2) [Source:UniProtKB/Swiss-Prot;Acc:P62879][hgnc]GNB2
Pteropus_vampyrusone2one ENSPVAG00000012018Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 (Transducin beta chain 2) (G protein subunit beta-2) [Source:UniProtKB/Swiss-Prot;Acc:P62879][hgnc]
Felis_catusone2one ENSFCAG00000006847Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 (Transducin beta chain 2) (G protein subunit beta-2) [Source:UniProtKB/Swiss-Prot;Acc:P62879][hgnc]
Microcebus_murinusone2one ENSMICG00000009371Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 (Transducin beta chain 2) (G protein subunit beta-2) [Source:UniProtKB/Swiss-Prot;Acc:P62879][hgnc]
Tupaia_belangerione2one ENSTBEG00000001166Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 (Transducin beta chain 2) (G protein subunit beta-2) [Source:UniProtKB/Swiss-Prot;Acc:P62879][hgnc]
Bos_taurusone2one ENSBTAG00000006495Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 (Transducin beta chain 2) (G protein subunit beta-2). [Source:UniProtKB/Swiss-Prot;Acc:P11017][hgnc]GNB2
Loxodonta_africanaone2one ENSLAFG00000017004Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 (Transducin beta chain 2) (G protein subunit beta-2) [Source:UniProtKB/Swiss-Prot;Acc:P62879][hgnc]
Otolemur_garnettiione2one ENSOGAG00000015133Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 (Transducin beta chain 2) (G protein subunit beta-2) [Source:UniProtKB/Swiss-Prot;Acc:P62879][hgnc]
Vicugna_pacosone2one ENSVPAG00000002101Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 (Transducin beta chain 2) (G protein subunit beta-2) [Source:UniProtKB/Swiss-Prot;Acc:P62879][hgnc]
Procavia_capensisone2one ENSPCAG00000006526Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 (Transducin beta chain 2) (G protein subunit beta-2) [Source:UniProtKB/Swiss-Prot;Acc:P62879][hgnc]
Dipodomys_ordiione2one ENSDORG00000016512Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 (Transducin beta chain 2) (G protein subunit beta-2) [Source:UniProtKB/Swiss-Prot;Acc:P62880][hgnc]
Cavia_porcellusone2one ENSCPOG00000019845Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 (Transducin beta chain 2) (G protein subunit beta-2) [Source:UniProtKB/Swiss-Prot;Acc:P62879][hgnc]
Ochotona_princepsone2one ENSOPRG00000015131Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 (Transducin beta chain 2) (G protein subunit beta-2) [Source:UniProtKB/Swiss-Prot;Acc:P62879][hgnc]
Myotis_lucifugusone2one ENSMLUG00000006764Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 (Transducin beta chain 2) (G protein subunit beta-2) [Source:UniProtKB/Swiss-Prot;Acc:P62879][hgnc]
Mus_musculusone2one ENSMUSG00000029713Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 (Transducin beta chain 2) (G protein subunit beta-2) [Source:UniProtKB/Swiss-Prot;Acc:P62880][hgnc]Gnb2
Rattus_norvegicusone2one ENSRNOG00000001409Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 (Transducin beta chain 2) (G protein subunit beta-2). [Source:UniProtKB/Swiss-Prot;Acc:P54313][hgnc]Gnb2
Echinops_telfairione2one ENSETEG00000012103Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 (Transducin beta chain 2) (G protein subunit beta-2) [Source:UniProtKB/Swiss-Prot;Acc:P62879][hgnc]
Oryctolagus_cuniculusone2one ENSOCUG00000002657Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 (Transducin beta chain 2) (G protein subunit beta-2) [Source:UniProtKB/Swiss-Prot;Acc:P62879][hgnc]
Sorex_araneusone2one ENSSARG00000003541Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 (Transducin beta chain 2) (G protein subunit beta-2) [Source:UniProtKB/Swiss-Prot;Acc:P62879][hgnc]
Monodelphis_domesticaone2one ENSMODG00000004610Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 (Transducin beta chain 2) (G protein subunit beta-2) [Source:UniProtKB/Swiss-Prot;Acc:P62879][hgnc]
Danio_rerioone2one ENSDARG00000035357hypothetical protein LOC541370 [Source:RefSeq_peptide;Acc:NP_001013515][hgnc]LOC100008434
Gasterosteus_aculeatusone2one ENSGACG00000020395Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 (Transducin beta chain 2) (G protein subunit beta-2) [Source:UniProtKB/Swiss-Prot;Acc:P62879][hgnc]
Oryzias_latipesone2one ENSORLG00000007905Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 (Transducin beta chain 2) (G protein subunit beta-2) [Source:UniProtKB/Swiss-Prot;Acc:P62879][hgnc]
Takifugu_rubripesone2one ENSTRUG00000016369Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 (Transducin beta chain 2) (G protein subunit beta-2) [Source:UniProtKB/Swiss-Prot;Acc:P62879][hgnc]
Tetraodon_nigroviridisone2one ENSTNIG00000011771Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 (Transducin beta chain 2) (G protein subunit beta-2) [Source:UniProtKB/Swiss-Prot;Acc:P62879][hgnc]
Caenorhabditis_elegansone2many F13D12.7gpb-1 encodes a heterotrimeric G protein beta subunit that is required during embryonic development for the proper orientation of the mitotic spindle during early cell divisions and thus affects the orientation of early cell division axes, and is also required for larval viability, negatively regulates locomotion and egg-laying, and may affect germline development and osmotic balance. expressed in early embryos with highest expression at cell membranes and colocalizes with asters just before and during early cell divisions (this localization is dependent upon G alpha subunits). adults display high levels of expression in neurons with lower expression in the somatic gonad, vulva, and hypodermal seam cells and expression is also detected in the intestine, pharynx, body wall muscles and in the germline. [Source: WormBase][hgnc]gpb-1
Anopheles_gambiaemany2many AGAP005912[hgnc]AgaP_ENSANGG00000011688
Anopheles_gambiaemany2many AGAP005911[hgnc]AgaP_ENSANGG00000011628
Drosophila_melanogasterone2many FBgn0001105[hgnc]Gbeta13F
Anopheles_gambiaemany2many AGAP005913[hgnc]AgaP_ENSANGG00000011108
Ciona_savignyione2many ENSCSAVG00000008875[hgnc]
Ciona_intestinalisone2many ENSCING00000003768[hgnc]
Aedes_aegyptimany2many AAEL013997guanine nucleotide-binding protein beta 3 (g protein beta3)[hgnc]
Aedes_aegyptimany2many AAEL013991guanine nucleotide-binding protein beta 3 (g protein beta3)[hgnc]
Aedes_aegyptimany2many AAEL001041guanine nucleotide-binding protein beta 3 (g protein beta3)[hgnc]