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Summary sheet information for Effector 'Rho-Homo sapiens-1'
Name Rho-Homo sapiens-1
Description RecName: Full=Rho-related GTP-binding protein Rho6;AltName: Full=Rho family GTPase 1;AltName: Full=Rnd1;Flags: Precursor
Class
Family Small GTP-binding proteins
Sub_family Rho small GTPases
type Rho
Protein features link Protein Information from Dasty2 DAS Client
GPCR, G-protein, Effector interaction Visualizaton of GPCR, G-protein, Effector interaction at protein level
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Genes
Gene Location:
Chromosome: 12
Gene Start: 47537198
Gene End: 47545948
Ensembl Contig View

Ensembl Genes:
ENSG00000172602

EMBL:
EMBL ID  Description
AB040147  Homo sapiens mRNA for Rnd1, complete cds.
AF498967  Homo sapiens small GTP binding protein Rho6 (Rho6) mRNA, complete cds.
AK292762  Homo sapiens cDNA FLJ76081 complete cds, highly similar to Homo sapiens Rho family GTPase 1 (RND1), mRNA.
BC026356  Homo sapiens Rho family GTPase 1, mRNA (cDNA clone MGC:26932 IMAGE:4793442), complete cds.
CH471111  Homo sapiens 211000035831639 genomic scaffold, whole genome shotgun sequence.
Y07923  H.sapiens mRNA for Rho6 protein

EntrezGene:
ID  Description
RND1  Rho family GTPase 1

RefSeq DNA:
ID  Description
NM_014470  Homo sapiens Rho family GTPase 1 (RND1), mRNA.

UniGene:
ID  Description

Proteins
Ensembl Proteins:
ENSP00000308461

Entrez Proteins:
AAH26356.1; AAM21114.1; BAB17851.1; BAF85451.1; CAA69228.1; EAW58019.1

RefSeq Proteins:
ID  Description
NP_055285  GTP-binding protein RHO6 [Homo sapiens].

UniProt:
ID  Description
A8K9P7  SubName: Full=cDNA FLJ76081, highly similar to Homo sapiens Rho family GTPase 1 (RND1), mRNA; SubName: Full=Rho family GTPase 1;
Q92730  RecName: Full=Rho-related GTP-binding protein Rho6; AltName: Full=Rho family GTPase 1; AltName: Full=Rnd1; Flags: Precursor;

Domains
SMART:
- Hyperlink to SMART; - Hyperlink to ENSEMBL
     Rho-Homo sapiens-1    

InterPro:
ID  Name
IPR003578  GTPase_Rho
IPR005225  Small_GTP_bd
IPR001806  Ras_trnsfrmng
IPR013753  Ras

Pfam:
ID  Description
Ras  Ras family

Structure
PDB:
ID
2CLS
2REX

HSSP:
ID  Description
1a2b  ONCOGENE PROTEIN
1a4r  HYDROLASE
1aje  G-PROTEIN
1an0  GTPASE
1cc0  SIGNALING PROTEIN
1cee  STRUCTURAL PROTEIN REGULATION
1cf4  TRANSFERASE
1cxz  SIGNALING PROTEIN
1doa  CELL CYCLE
1dpf  GENE REGULATION/SIGNALING PROTEIN
1ds6  SIGNALING PROTEIN
1e0a  SIGNALLING PROTEIN
1e96  SIGNALLING COMPLEX
1ees  STRUCTURAL PROTEIN
1ftn  PROTO-ONCOGENE
1g4u  SIGNALING PROTEIN
1gwn  GTPASE
1gzs  COMPLEX (TOXIN/CELL CYCLE PROTEIN)
1he1  SIGNALLING COMPLEX
1hh4  SINGAL PROTEIN INHIBITOR COMPLEX
1i4d  SIGNALING PROTEIN
1i4l  SIGNALING PROTEIN
1i4t  SIGNALING PROTEIN
1kmq  SIGNALING PROTEIN
1kz7  SIGNALING PROTEIN
1m7b  SIGNALING PROTEIN
1mh1  GTP-BINDING
1ryf  HYDROLASE
1ryh  HYDROLASE
1s1c  SIGNALING PROTEIN
1z2c  SIGNALING PROTEIN
2ase  SIGNALING PROTEIN
2atx  HYDROLASE
2c2h  SIGNALING PROTEIN
2cls  NUCLEOTIDE BINDING PROTEIN
2fju  SIGNALING PROTEIN,APOPTOSIS/HYDROLASE
2fv8  SIGNALING PROTEIN
2g0n  SIGNALING PROTEIN
2gcn  SIGNALING PROTEIN
2gco  SIGNALING PROTEIN
2gcp  SIGNALING PROTEIN
2h7v  SIGNALING PROTEIN
2ic5  SIGNALING PROTEIN
2j0v  NUCLEOTIDE-BINDING PROTEIN
2j1l  HYDROLASE
2nty  SIGNALING PROTEIN
2odb  PROTEIN BINDING
2ov2  PROTEIN BINDING/TRANSFERASE
2p2l  UNKNOWN FUNCTION
2q3h  STRUCTURAL GENOMICS
2qme  SIGNALING PROTEIN/TRANSFERASE
2qrz  CELL CYCLE
2rex  SIGNALING PROTEIN/LIPOPROTEIN
2rmk  MEMBRANE PROTEIN/TRANSFERASE
2v55  TRANSFERASE
3eg5  SIGNALING PROTEIN

PSSH:
ID  Description
Q92730  UNKNOWN

Diseases
OMIM:
OMIM ID  Name  Alt Name
609038  RHO FAMILY GTPase 1; RND1   RHO6

Gene Ontology
GO:
GO ID  Description
GO:0000166  nucleotide binding
GO:0003924  GTPase activity
GO:0005525  GTP binding
GO:0005622  intracellular
GO:0005737  cytoplasm
GO:0005856  cytoskeleton
GO:0005886  plasma membrane
GO:0005912  adherens junction
GO:0007015  actin filament organization
GO:0007162  negative regulation of cell adhesion
GO:0007264  small GTPase mediated signal transduction
GO:0015031  protein transport
GO:0016322  neuron remodeling

Pathway
KEGG:
KEGG PATHWAY ID  Name
hsa04360  Axon guidance

Panther:
ID  Description
P00034  Integrin signalling pathway

Chemicals
DrugBank:
ID  Name  Synonyms
HMDB:
ID  Name  Synonyms
Orthology
Orthology Relations:
Gene Gene Description Organism Orthology type Orthologs Orthologs Description
ENSG00000172602 Rho-related GTP-binding protein Rho6 Precursor (Rho family GTPase 1) (Rnd1) [Source:UniProtKB/Swiss-Prot;Acc:Q92730] Pan_troglodytesone2one ENSPTRG00000004888Rho-related GTP-binding protein Rho6 Precursor (Rho family GTPase 1) (Rnd1) [Source:UniProtKB/Swiss-Prot;Acc:Q92730][hgnc]RND1
Pongo_pygmaeusone2one ENSPPYG00000004469Rho-related GTP-binding protein Rho6 Precursor (Rho family GTPase 1) (Rnd1) [Source:UniProtKB/Swiss-Prot;Acc:Q92730][hgnc]
Macaca_mulattaone2one ENSMMUG00000008433Rho-related GTP-binding protein Rho6 Precursor (Rho family GTPase 1) (Rnd1) [Source:UniProtKB/Swiss-Prot;Acc:Q92730][hgnc]
Microcebus_murinusone2one ENSMICG00000017542Rho-related GTP-binding protein Rho6 Precursor (Rho family GTPase 1) (Rnd1) [Source:UniProtKB/Swiss-Prot;Acc:Q92730][hgnc]
Equus_caballusone2one ENSECAG00000020971Rho-related GTP-binding protein Rho6 Precursor (Rho family GTPase 1) (Rnd1) [Source:UniProtKB/Swiss-Prot;Acc:Q92730][hgnc]LOC100058747
Pteropus_vampyrusone2one ENSPVAG00000009824Rho-related GTP-binding protein Rho6 Precursor (Rho family GTPase 1) (Rnd1) [Source:UniProtKB/Swiss-Prot;Acc:Q92730][hgnc]
Myotis_lucifugusone2one ENSMLUG00000011066Rho-related GTP-binding protein Rho6 Precursor (Rho family GTPase 1) (Rnd1) [Source:UniProtKB/Swiss-Prot;Acc:Q92730][hgnc]
Tarsius_syrichtaone2one ENSTSYG00000011589Rho-related GTP-binding protein Rho6 Precursor (Rho family GTPase 1) (Rnd1) [Source:UniProtKB/Swiss-Prot;Acc:Q92730][hgnc]
Tursiops_truncatusone2one ENSTTRG00000004652Rho-related GTP-binding protein Rho6 Precursor (Rho family GTPase 1) (Rnd1) [Source:UniProtKB/Swiss-Prot;Acc:Q92730][hgnc]
Felis_catusone2one ENSFCAG00000000084Rho-related GTP-binding protein Rho6 Precursor (Rho family GTPase 1) (Rnd1) [Source:UniProtKB/Swiss-Prot;Acc:Q92730][hgnc]
Otolemur_garnettiione2one ENSOGAG00000016822Rho-related GTP-binding protein Rho6 Precursor (Rho family GTPase 1) (Rnd1) [Source:UniProtKB/Swiss-Prot;Acc:Q92730][hgnc]
Tupaia_belangerione2one ENSTBEG00000017126Rho-related GTP-binding protein Rho6 Precursor (Rho family GTPase 1) (Rnd1) [Source:UniProtKB/Swiss-Prot;Acc:Q92730][hgnc]
Loxodonta_africanaone2one ENSLAFG00000010202Rho-related GTP-binding protein Rho6 Precursor (Rho family GTPase 1) (Rnd1) [Source:UniProtKB/Swiss-Prot;Acc:Q92730][hgnc]
Cavia_porcellusone2one ENSCPOG00000003220Rho-related GTP-binding protein Rho6 Precursor (Rho family GTPase 1) (Rnd1) [Source:UniProtKB/Swiss-Prot;Acc:Q92730][hgnc]
Canis_familiarisone2one ENSCAFG00000008811Rho-related GTP-binding protein Rho6 Precursor (Rho family GTPase 1) (Rnd1) [Source:UniProtKB/Swiss-Prot;Acc:Q92730][hgnc]RND1
Dipodomys_ordiione2one ENSDORG00000003299Rho-related GTP-binding protein Rho6 Precursor (Rho family GTPase 1) (Rnd1) [Source:UniProtKB/Swiss-Prot;Acc:Q8BLR7][hgnc]
Bos_taurusone2one ENSBTAG00000018773Rho-related GTP-binding protein Rho6 precursor (Rho family GTPase 1) (Rnd1). [Source:UniProtKB/Swiss-Prot;Acc:Q2HJ68][hgnc]RND1
Dasypus_novemcinctusone2one ENSDNOG00000006584Rho-related GTP-binding protein Rho6 Precursor (Rho family GTPase 1) (Rnd1) [Source:UniProtKB/Swiss-Prot;Acc:Q92730][hgnc]
Spermophilus_tridecemlineatusone2one ENSSTOG00000004257Rho-related GTP-binding protein Rho6 Precursor (Rho family GTPase 1) (Rnd1) [Source:UniProtKB/Swiss-Prot;Acc:Q92730][hgnc]
Erinaceus_europaeusone2one ENSEEUG00000015869Rho-related GTP-binding protein Rho6 Precursor (Rho family GTPase 1) (Rnd1) [Source:UniProtKB/Swiss-Prot;Acc:Q92730][hgnc]
Rattus_norvegicusone2one ENSRNOG00000013621Rho family GTPase 1 [Source:RefSeq_peptide;Acc:NP_001013240][hgnc]Rnd1
Procavia_capensisone2one ENSPCAG00000002103Rho-related GTP-binding protein Rho6 Precursor (Rho family GTPase 1) (Rnd1) [Source:UniProtKB/Swiss-Prot;Acc:Q92730][hgnc]
Sorex_araneusone2one ENSSARG00000004593Rho-related GTP-binding protein Rho6 Precursor (Rho family GTPase 1) (Rnd1) [Source:UniProtKB/Swiss-Prot;Acc:Q92730][hgnc]
Echinops_telfairione2one ENSETEG00000017942Rho-related GTP-binding protein Rho6 Precursor (Rho family GTPase 1) (Rnd1) [Source:UniProtKB/Swiss-Prot;Acc:Q92730][hgnc]
Mus_musculusone2one ENSMUSG00000054855Rho-related GTP-binding protein Rho6 Precursor (Rho family GTPase 1) (Rnd1) [Source:UniProtKB/Swiss-Prot;Acc:Q8BLR7][hgnc]Rnd1
Ochotona_princepsone2one ENSOPRG00000006802Rho-related GTP-binding protein Rho6 Precursor (Rho family GTPase 1) (Rnd1) [Source:UniProtKB/Swiss-Prot;Acc:Q92730][hgnc]
Xenopus_tropicalisone2one ENSXETG00000009811MGC79716 protein. [Source:UniProtKB/TrEMBL;Acc:Q66JC6][hgnc]
Gasterosteus_aculeatusone2many ENSGACG00000008549Rho-related GTP-binding protein Rho6 Precursor (Rho family GTPase 1) (Rnd1) [Source:UniProtKB/Swiss-Prot;Acc:Q92730][hgnc]
Takifugu_rubripesone2many ENSTRUG00000015649Rho-related GTP-binding protein Rho6 Precursor (Rho family GTPase 1) (Rnd1) [Source:UniProtKB/Swiss-Prot;Acc:Q92730][hgnc]
Gasterosteus_aculeatusone2many ENSGACG00000003002Rho-related GTP-binding protein Rho6 Precursor (Rho family GTPase 1) (Rnd1) [Source:UniProtKB/Swiss-Prot;Acc:Q92730][hgnc]
Tetraodon_nigroviridisone2one ENSTNIG00000015099Rho-related GTP-binding protein Rho6 Precursor (Rho family GTPase 1) (Rnd1) [Source:UniProtKB/Swiss-Prot;Acc:Q92730][hgnc]
Danio_rerioone2many ENSDARG00000004218Rho family GTPase 1 like [Source:RefSeq_peptide;Acc:NP_001037861][hgnc]rnd1l
Takifugu_rubripesone2many ENSTRUG00000000426Rho-related GTP-binding protein Rho6 Precursor (Rho family GTPase 1) (Rnd1) [Source:UniProtKB/Swiss-Prot;Acc:Q92730][hgnc]
Oryzias_latipesone2one ENSORLG00000012314Rho-related GTP-binding protein Rho6 Precursor (Rho family GTPase 1) (Rnd1) [Source:UniProtKB/Swiss-Prot;Acc:Q92730][hgnc]
Danio_rerioone2many ENSDARG00000030547Rho family GTPase 1 [Source:RefSeq_peptide;Acc:NP_998019][hgnc]rnd1b
Saccharomyces_cerevisiaemany2many YIL118WGTP-binding protein RHO3 precursor. [Source:UniProtKB/Swiss-Prot;Acc:Q00245][hgnc]RHO3
Saccharomyces_cerevisiaemany2many YNL090WGTP-binding protein RHO2 precursor. [Source:UniProtKB/Swiss-Prot;Acc:P06781][hgnc]RHO2