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Summary sheet information for Effector 'GRK2-Homo sapiens'
Name GRK2-Homo sapiens
Description RecName: Full=Beta-adrenergic receptor kinase 1; Short=Beta-ARK-1; EC=2.7.11.15;AltName: Full=G-protein coupled receptor kinase 2
Class
Family Ser Thr protein kinases
Sub_family G protein coupled receptor kinases
type GRK2
Protein features link Protein Information from Dasty2 DAS Client
GPCR, G-protein, Effector interaction Visualizaton of GPCR, G-protein, Effector interaction at protein level
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Genes
Gene Location:
Chromosome: 11
Gene Start: 66790481
Gene End: 66810605
Ensembl Contig View

Ensembl Genes:
ENSG00000173020

EMBL:
EMBL ID  Description
AB209588  Homo sapiens mRNA for beta adrenergic receptor kinase 1 variant protein.
BC037963  Homo sapiens adrenergic, beta, receptor kinase 1, mRNA (cDNA clone MGC:46122 IMAGE:5585846), complete cds.
BC090863  Homo sapiens adrenergic, beta, receptor kinase 1, mRNA (cDNA clone MGC:102807 IMAGE:6203199), complete cds.
EU326303  Homo sapiens adrenergic, beta, receptor kinase 1 (ADRBK1) gene, complete cds.
M80776  Human beta-adrenergic receptor kinase 1 mRNA, complete cds.
U08435  Homo sapiens beta-adrenergic receptor kinase (ADR) gene, exon 1.
U08436  Homo sapiens beta-adrenergic receptor kinase (ADR) gene, exon 2.
U08437  Homo sapiens beta-adrenergic receptor kinase (ADR) gene, exons 3, 4, 5, and 6.
U08438  Homo sapiens beta-adrenergic receptor kinase (ADR) gene, exons 7 through 21, and complete cds.
X61157  H.sapiens mRNA for beta-adrenergic receptor kinase

EntrezGene:
ID  Description
ADRBK1  adrenergic, beta, receptor kinase 1

RefSeq DNA:
ID  Description
NM_001619  Homo sapiens adrenergic, beta, receptor kinase 1 (ADRBK1), mRNA.

UniGene:
ID  Description
Hs.83636  Adrenergic, beta, receptor kinase 1, mRNA (cDNA clone MGC:46122 IMAGE:5585846)

Proteins
Ensembl Proteins:
ENSP00000312262

Entrez Proteins:
AAA58391.1; AAB60689.1; AAH37963.1; AAH90863.1; ACA05909.1; BAD92825.1; CAA43470.1

RefSeq Proteins:
ID  Description
NP_001610  beta-adrenergic receptor kinase 1 [Homo sapiens].

UniProt:
ID  Description
B0ZBE1  UNKNOWN
Q59F73  SubName: Full=Beta adrenergic receptor kinase 1 variant; Flags: Fragment;
P25098  RecName: Full=Beta-adrenergic receptor kinase 1; Short=Beta-ARK-1; EC=2.7.11.15; AltName: Full=G-protein coupled receptor kinase 2;

Domains
SMART:
- Hyperlink to SMART; - Hyperlink to ENSEMBL
     GRK2-Homo sapiens    

InterPro:
ID  Name
IPR011993  PH_type
IPR017442  Se/Thr_pkinase-rel
IPR000342  Regulat_G_prot_signal
IPR017441  Protein_kinase_ATP_bd_CS
IPR008271  Ser_thr_pkin_AS
IPR000719  Prot_kinase_core
IPR001849  Pleckstrin_homology
IPR000239  GPCR_kinase
IPR015743  BARK
IPR002290  Ser_thr_pkinase
IPR000961  Pkinase_C

Pfam:
ID  Description
Pkinase  Protein kinase domain
PH  PH domain
RGS  Regulator of G protein signaling domain

Structure
PDB:
ID
1BAK
3CIK

HSSP:
ID  Description
1bak  TRANSFERASE
1gzk  KINASE
1gzn  KINASE
1gzo  KINASE
1h1w  TRANSFERASE
1mrv  TRANSFERASE
1mry  TRANSFERASE
1o6k  TRANSFERASE
1o6l  TRANSFERASE
1okz  TRANSFERASE
1omw  TRANSFERASE
1uu3  TRANSFERASE
1uvr  TRANSFERASE
1vzo  TRANSFERASE
1ym7  TRANSFERASE
1z5m  TRANSFERASE
2acx  TRANSFERASE
2bcj  TRANSFERASE/HYDROLASE
2i0e  TRANSFERASE
2jdo  TRANSFERASE
2jdr  TRANSFERASE
2pe0  TRANSFERASE
2pe1  TRANSFERASE
2pe2  TRANSFERASE
2r5t  TRANSFERASE
2uw9  TRANSFERASE/INHIBITOR COMPLEX
2z7q  TRANSFERASE
2z7r  TRANSFERASE
2z7s  TRANSFERASE
3c4w  TRANSFERASE
3c4x  TRANSFERASE
3c4y  TRANSFERASE
3c4z  TRANSFERASE
3c50  TRANSFERASE
3c51  TRANSFERASE
3cqu  TRANSFERASE
3cqw  TRANSFERASE
3d0e  TRANSFERASE INHIBITOR
3e87  TRANSFERASE
3e88  TRANSFERASE
3e8d  TRANSFERASE

PSSH:
ID  Description
Q59F73  UNKNOWN
P25098  UNKNOWN

Diseases
OMIM:
OMIM ID  Name  Alt Name
109635  BETA-ADRENERGIC RECEPTOR KINASE 1; ADRBK1   BARK1 BETA-ARK1 G PROTEIN-DEPENDENT RECEPTOR KINASE 2; GRK2

Gene Ontology
GO:
GO ID  Description
GO:0000166  nucleotide binding
GO:0002026  regulation of the force of heart contraction
GO:0002029  desensitization of G-protein coupled receptor protein signaling pathway
GO:0003108  negative regulation of the force of heart contraction by chemical signal
GO:0004672  protein kinase activity
GO:0004674  protein serine/threonine kinase activity
GO:0004703  G-protein coupled receptor kinase activity
GO:0004713  protein tyrosine kinase activity
GO:0004871  signal transducer activity
GO:0004872  receptor activity
GO:0005515  protein binding
GO:0005524  ATP binding
GO:0005625  soluble fraction
GO:0005737  cytoplasm
GO:0006468  protein amino acid phosphorylation
GO:0007165  signal transduction
GO:0007186  G-protein coupled receptor protein signaling pathway
GO:0007213  muscarinic acetylcholine receptor signaling pathway
GO:0007217  tachykinin receptor signaling pathway
GO:0007507  heart development
GO:0016020  membrane
GO:0016740  transferase activity
GO:0018105  peptidyl-serine phosphorylation
GO:0033605  positive regulation of catecholamine secretion
GO:0045988  negative regulation of striated muscle contraction
GO:0047696  beta-adrenergic receptor kinase activity
GO:0060048  cardiac muscle contraction

Pathway
KEGG:
KEGG PATHWAY ID  Name
hsa04062  Chemokine signaling pathway
hsa04144  Endocytosis

Panther:
ID  Description
P05911  Angiotensin II-stimulated signaling through G proteins and beta-arrestin
P00026  Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
P00049  Parkinson disease
P00031  Inflammation mediated by chemokine and cytokine signaling pathway

Chemicals
DrugBank:
ID  Name  Synonyms
HMDB:
ID  Name  Synonyms
Orthology
Orthology Relations:
Gene Gene Description Organism Orthology type Orthologs Orthologs Description
ENSG00000173020 Beta-adrenergic receptor kinase 1 (EC 2.7.11.15) (Beta-ARK-1) (G-protein coupled receptor kinase 2) [Source:UniProtKB/Swiss-Prot;Acc:P25098] Pan_troglodytesone2one ENSPTRG00000003946Beta-adrenergic receptor kinase 1 (EC 2.7.11.15) (Beta-ARK-1) (G-protein coupled receptor kinase 2) [Source:UniProtKB/Swiss-Prot;Acc:P25098][hgnc]LOC746868
Pongo_pygmaeusone2one ENSPPYG00000003000Beta-adrenergic receptor kinase 1 (EC 2.7.11.15) (Beta-ARK-1) (G-protein coupled receptor kinase 2) [Source:UniProtKB/Swiss-Prot;Acc:P25098][hgnc]
Macaca_mulattaone2one ENSMMUG00000015925Beta-adrenergic receptor kinase 1 (EC 2.7.11.15) (Beta-ARK-1) (G-protein coupled receptor kinase 2) [Source:UniProtKB/Swiss-Prot;Acc:P25098][hgnc]
Microcebus_murinusone2one ENSMICG00000004063Beta-adrenergic receptor kinase 1 (EC 2.7.11.15) (Beta-ARK-1) (G-protein coupled receptor kinase 2) [Source:UniProtKB/Swiss-Prot;Acc:P25098][hgnc]
Equus_caballusone2one ENSECAG00000002944Adrenergic receptor beta kinase I (Fragment). [Source:UniProtKB/TrEMBL;Acc:Q9N1W8][hgnc]LOC100059001
Spermophilus_tridecemlineatusone2one ENSSTOG00000015686Beta-adrenergic receptor kinase 1 (EC 2.7.11.15) (Beta-ARK-1) (G-protein coupled receptor kinase 2) [Source:UniProtKB/Swiss-Prot;Acc:P25098][hgnc]
Tursiops_truncatusone2one ENSTTRG00000001878Beta-adrenergic receptor kinase 1 (EC 2.7.11.15) (Beta-ARK-1) (G-protein coupled receptor kinase 2) [Source:UniProtKB/Swiss-Prot;Acc:P25098][hgnc]
Myotis_lucifugusone2one ENSMLUG00000005075Beta-adrenergic receptor kinase 1 (EC 2.7.11.15) (Beta-ARK-1) (G-protein coupled receptor kinase 2) [Source:UniProtKB/Swiss-Prot;Acc:P25098][hgnc]
Felis_catusone2one ENSFCAG00000003386Beta-adrenergic receptor kinase 1 (EC 2.7.11.15) (Beta-ARK-1) (G-protein coupled receptor kinase 2) [Source:UniProtKB/Swiss-Prot;Acc:P25098][hgnc]
Tupaia_belangerione2one ENSTBEG00000003700Beta-adrenergic receptor kinase 1 (EC 2.7.11.15) (Beta-ARK-1) (G-protein coupled receptor kinase 2) [Source:UniProtKB/Swiss-Prot;Acc:P25098][hgnc]
Pteropus_vampyrusone2one ENSPVAG00000008543Beta-adrenergic receptor kinase 1 (EC 2.7.11.15) (Beta-ARK-1) (G-protein coupled receptor kinase 2) [Source:UniProtKB/Swiss-Prot;Acc:P25098][hgnc]
Bos_taurusone2one ENSBTAG00000005832Beta-adrenergic receptor kinase 1 (EC 2.7.11.15) (Beta-ARK-1) (G- protein-coupled receptor kinase 2). [Source:UniProtKB/Swiss-Prot;Acc:P21146][hgnc]ADRBK1
Otolemur_garnettiione2one ENSOGAG00000010638Beta-adrenergic receptor kinase 1 (EC 2.7.11.15) (Beta-ARK-1) (G-protein coupled receptor kinase 2) [Source:UniProtKB/Swiss-Prot;Acc:P25098][hgnc]
Cavia_porcellusone2one ENSCPOG00000015449Beta-adrenergic receptor kinase 1 (EC 2.7.11.15) (Beta-ARK-1) (G-protein coupled receptor kinase 2) [Source:UniProtKB/Swiss-Prot;Acc:P25098][hgnc]
Ochotona_princepsone2one ENSOPRG00000013614Beta-adrenergic receptor kinase 1 (EC 2.7.11.15) (Beta-ARK-1) (G-protein coupled receptor kinase 2) [Source:UniProtKB/Swiss-Prot;Acc:P25098][hgnc]
Loxodonta_africanaone2one ENSLAFG00000015685Beta-adrenergic receptor kinase 1 (EC 2.7.11.15) (Beta-ARK-1) (G-protein coupled receptor kinase 2) [Source:UniProtKB/Swiss-Prot;Acc:P25098][hgnc]
Dipodomys_ordiione2one ENSDORG00000010940Beta-adrenergic receptor kinase 1 (EC 2.7.11.15) (Beta-ARK-1) (G-protein-coupled receptor kinase 2) [Source:UniProtKB/Swiss-Prot;Acc:Q99MK8][hgnc]
Canis_familiarisone2one ENSCAFG00000011733Beta-adrenergic receptor kinase 1 (EC 2.7.11.15) (Beta-ARK-1) (G-protein coupled receptor kinase 2) [Source:UniProtKB/Swiss-Prot;Acc:P25098][hgnc]ADRBK1
Procavia_capensisone2one ENSPCAG00000011349Beta-adrenergic receptor kinase 1 (EC 2.7.11.15) (Beta-ARK-1) (G-protein coupled receptor kinase 2) [Source:UniProtKB/Swiss-Prot;Acc:P25098][hgnc]
Echinops_telfairione2one ENSETEG00000010299Beta-adrenergic receptor kinase 1 (EC 2.7.11.15) (Beta-ARK-1) (G-protein coupled receptor kinase 2) [Source:UniProtKB/Swiss-Prot;Acc:P25098][hgnc]
Rattus_norvegicusone2one ENSRNOG00000018985Beta-adrenergic receptor kinase 1 (EC 2.7.11.15) (Beta-ARK-1) (G- protein-coupled receptor kinase 2). [Source:UniProtKB/Swiss-Prot;Acc:P26817][hgnc]Adrbk1
Erinaceus_europaeusone2one ENSEEUG00000002110Beta-adrenergic receptor kinase 1 (EC 2.7.11.15) (Beta-ARK-1) (G-protein coupled receptor kinase 2) [Source:UniProtKB/Swiss-Prot;Acc:P25098][hgnc]
Mus_musculusone2one ENSMUSG00000024858Beta-adrenergic receptor kinase 1 (EC 2.7.11.15) (Beta-ARK-1) (G-protein-coupled receptor kinase 2) [Source:UniProtKB/Swiss-Prot;Acc:Q99MK8][hgnc]Adrbk1
Ornithorhynchus_anatinusone2one ENSOANG00000007632Beta-adrenergic receptor kinase 1 (EC 2.7.11.15) (Beta-ARK-1) (G-protein coupled receptor kinase 2) [Source:UniProtKB/Swiss-Prot;Acc:P25098][hgnc]100090102
Gallus_gallusone2one ENSGALG00000018763Gallus gallus similar to receptor kinase (LOC426000), mRNA. [Source:RefSeq_dna;Acc:NM_001031353][hgnc]RCJMB04_19g20
Anopheles_gambiaeone2many AGAP012026[hgnc]AgaP_ENSANGG00000006518
Aedes_aegyptione2many AAEL006868beta-adrenergic receptor kinase[hgnc]
Caenorhabditis_elegansone2many W02B3.2grk-2 encodes a serine/threonine protein kinase that is most closely related to G protein-coupled receptor (GPCR) kinases. in C. elegans, grk-2 activity is required in chemosensory neurons for normal calcium influx during chemosensation, but is not required for GPCR downregulation. in regulating chemosensation, GRK-2 likely acts upstream of the ODR-3/G alpha protein, as overexpression of ODR-3 can rescue abnormal avoidance behavior in grk-2 mutants. GRK-2 is broadly expressed in the adult nervous system, with expression beginning as early as the 20-30-cell stage of embryonic development and continuing into adulthood. [Source: WormBase][hgnc]grk-2
Drosophila_melanogasterone2many FBgn0004833[hgnc]Gprk1
Ciona_savignyione2many ENSCSAVG00000001890[hgnc]
Ciona_intestinalismany2many ENSCING00000016524[hgnc]
Ciona_intestinalismany2many ENSCING00000001450[hgnc]