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Summary sheet information for Effector 'Adenylate cyclase 5-Homo sapiens'
Name Adenylate cyclase 5-Homo sapiens
Description RecName: Full=Adenylate cyclase type 5; EC=4.6.1.1;AltName: Full=Adenylate cyclase type V;AltName: Full=ATP pyrophosphate-lyase 5;AltName: Full=Adenylyl cyclase 5
Class
Family Cyclases
Sub_family Adenylate cyclases
type Adenylate cyclase 5
Protein features link Protein Information from Dasty2 DAS Client
GPCR, G-protein, Effector interaction Visualizaton of GPCR, G-protein, Effector interaction at protein level
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Genes
Gene Location:
Chromosome: 3
Gene Start: 124485481
Gene End: 124650082
Ensembl Contig View

Ensembl Genes:
ENSG00000173175

EMBL:
EMBL ID  Description
AC025571  Homo sapiens 3 BAC RP11-515C21 (Roswell Park Cancer Institute Human BAC Library) complete sequence.
AF497517  Homo sapiens adenylate cyclase type V (ADCY5) mRNA, partial cds.
BK000371  TPA: Homo sapiens adenylyl cyclase type V (ADCY5) mRNA, partial cds.
U65473  Homo sapiens adenylyl cyclase type V mRNA, partial cds.

EntrezGene:
ID  Description
ADCY5  adenylate cyclase 5

RefSeq DNA:
ID  Description
NM_183357  Homo sapiens adenylate cyclase 5 (ADCY5), mRNA.

UniGene:
ID  Description

Proteins
Ensembl Proteins:
ENSP00000308685

Entrez Proteins:
AAD00121.1; AAM94374.1; DAA00057.1

RefSeq Proteins:
ID  Description
NP_899200  adenylate cyclase 5 [Homo sapiens].

UniProt:
ID  Description
O95622  RecName: Full=Adenylate cyclase type 5; EC=4.6.1.1; AltName: Full=Adenylate cyclase type V; AltName: Full=ATP pyrophosphate-lyase 5; AltName: Full=Adenylyl cyclase 5;

Domains
SMART:
- Hyperlink to SMART; - Hyperlink to ENSEMBL
     Adenylate cyclase 5-Homo sapiens    

InterPro:
ID  Name
IPR009398  Aden_cycl_like
IPR001054  A/G_cyclase

Pfam:
ID  Description
Guanylate_cyc  Adenylate and Guanylate cyclase catalytic domain
DUF1053  Domain of Unknown Function (DUF1053)

Structure
PDB:
ID

HSSP:
ID  Description
1ab8  LYASE
1azs  COMPLEX (LYASE/HYDROLASE)
1cjk  LYASE/LYASE/SIGNALING PROTEIN
1cjt  LYASE/LYASE/SIGNALING PROTEIN
1cju  LYASE/LYASE/SIGNALING PROTEIN
1cjv  LYASE/LYASE/SIGNALING PROTEIN
1cs4  LYASE/LYASE/SIGNALING PROTEIN
1cul  LYASE/LYASE/SIGNALING PROTEIN
1tl7  LYASE
1u0h  LYASE
1yk9  LYASE
2gvd  LYASE
2gvz  LYASE
3c14  LYASE/LYASE INHIBITOR
3c15  LYASE/LYASE INHIBITOR
3c16  LYASE/LYASE INHIBITOR
3et6  LYASE

PSSH:
ID  Description
O95622  UNKNOWN

Diseases
OMIM:
OMIM ID  Name  Alt Name
600293  ADENYLATE CYCLASE 5; ADCY5   ADENYLYL CYCLASE 5

Gene Ontology
GO:
GO ID  Description
GO:0000287  magnesium ion binding
GO:0001973  adenosine receptor signaling pathway
GO:0004016  adenylate cyclase activity
GO:0005886  plasma membrane
GO:0006171  cAMP biosynthetic process
GO:0007191  activation of adenylate cyclase activity by dopamine receptor signaling pathway
GO:0007195  inhibition of adenylate cyclase activity by dopamine receptor signaling pathway
GO:0007242  intracellular signaling cascade
GO:0007626  locomotory behavior
GO:0009190  cyclic nucleotide biosynthetic process
GO:0016021  integral to membrane
GO:0016849  phosphorus-oxygen lyase activity
GO:0050885  neuromuscular process controlling balance

Pathway
KEGG:
KEGG PATHWAY ID  Name
hsa04062  Chemokine signaling pathway
hsa05414  Dilated cardiomyopathy
hsa04540  Gap junction
hsa04912  GnRH signaling pathway
hsa04916  Melanogenesis
hsa04114  Oocyte meiosis
hsa04914  Progesterone-mediated oocyte maturation
hsa00230  Purine metabolism
hsa04270  Vascular smooth muscle contraction

Panther:
ID  Description
P05731  GABA-B receptor II signaling

Chemicals
DrugBank:
ID  Name  Synonyms
HMDB:
ID  Name  Synonyms
HMDB00058   Cyclic AMP   Cyclic AMP; 3'5'-cyclic AMP; 6-(6-Amino-9H-purin-9-yl)tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinine-2,7-diol 2-oxide; Acrasin; Adenosine 3',5'-cyclic monophosphate; Adenosine 3',5'-cyclic phosphate; Adenosine 3',5'-cyclophosphate; Adenosine 3',5'-monophosphate; Adenosine 3,5'-cyclic monophosphorate; Adenosine 3,5'-cyclic monophosphoric acid; Adenosine cyclic monophosphate; Cyclic 3',5'-AMP; Cyclic 3',5'-adenylate; Cyclic 3',5'-adenylic acid; Cyclic adenosine 3',5'-phosphate; adenosine cyclic-monophosphate; adenosine-cyclic-phosphate; adenosine-cyclic-phosphoric-acid; cAMP
HMDB00538   Adenosine triphosphate   5'-(tetrahydrogen triphosphate) Adenosine; 5'-ATP; ATP; Adenosine 5'-triphosphate; Adenosine 5'-triphosphorate; Adenosine 5'-triphosphoric acid; Adenosine triphosphate; Adenosine triphosphic acid; Adenylpyrophosphorate; Adenylpyrophosphoric acid; Adephos; Adetol; Adynol; Atipi; Atriphos; Cardenosine; Fosfobion; Glucobasin; Myotriphos; Phosphobion; Striadyne; Triadenyl; Triphosphaden; Triphosphoric acid adenosine ester
HMDB00250   Pyrophosphate   (4-)Diphosphoric acid ion; (P2O74-)Diphosphate; Diphosphate; Pyrometaphosphate; Pyrophosphate; Pyrophosphate tetraanion; Pyrophosphate(4-) ion; Pyrophosphic acid
Orthology
Orthology Relations:
Gene Gene Description Organism Orthology type Orthologs Orthologs Description
ENSG00000173175 Adenylate cyclase type 5 (EC 4.6.1.1) (Adenylate cyclase type V) (ATP pyrophosphate-lyase 5) (Adenylyl cyclase 5) [Source:UniProtKB/Swiss-Prot;Acc:O95622] Ciona_intestinalisone2many ENSCING00000000292Adenylate cyclase (Fragment). [Source:UniProtKB/TrEMBL;Acc:Q69HQ2][hgnc]
Aedes_aegyptione2many AAEL001034adenylate cyclase type vi[hgnc]
Pan_troglodytesone2one ENSPTRG00000015304Adenylate cyclase type 5 (EC 4.6.1.1) (Adenylate cyclase type V) (ATP pyrophosphate-lyase 5) (Adenylyl cyclase 5) [Source:UniProtKB/Swiss-Prot;Acc:O95622][hgnc]
Pongo_pygmaeusone2one ENSPPYG00000013473Adenylate cyclase type 5 (EC 4.6.1.1) (Adenylate cyclase type V) (ATP pyrophosphate-lyase 5) (Adenylyl cyclase 5) [Source:UniProtKB/Swiss-Prot;Acc:O95622][hgnc]
Macaca_mulattaone2one ENSMMUG00000002230Adenylate cyclase type 5 (EC 4.6.1.1) (Adenylate cyclase type V) (ATP pyrophosphate-lyase 5) (Adenylyl cyclase 5) [Source:UniProtKB/Swiss-Prot;Acc:O95622][hgnc]
Equus_caballusone2one ENSECAG00000009948Adenylate cyclase type 5 (EC 4.6.1.1) (Adenylate cyclase type V) (ATP pyrophosphate-lyase 5) (Adenylyl cyclase 5) [Source:UniProtKB/Swiss-Prot;Acc:O95622][hgnc]
Dasypus_novemcinctusone2one ENSDNOG00000009964Adenylate cyclase type 5 (EC 4.6.1.1) (Adenylate cyclase type V) (ATP pyrophosphate-lyase 5) (Adenylyl cyclase 5) [Source:UniProtKB/Swiss-Prot;Acc:O95622][hgnc]
Myotis_lucifugusone2one ENSMLUG00000008225Adenylate cyclase type 5 (EC 4.6.1.1) (Adenylate cyclase type V) (ATP pyrophosphate-lyase 5) (Adenylyl cyclase 5) [Source:UniProtKB/Swiss-Prot;Acc:O95622][hgnc]
Oryctolagus_cuniculusone2one ENSOCUG00000015141Adenylate cyclase type 5 (EC 4.6.1.1) (Adenylate cyclase type V) (ATP pyrophosphate-lyase 5) (Adenylyl cyclase 5) [Source:UniProtKB/Swiss-Prot;Acc:O95622][hgnc]
Tupaia_belangerione2one ENSTBEG00000014150Adenylate cyclase type 5 (EC 4.6.1.1) (Adenylate cyclase type V) (ATP pyrophosphate-lyase 5) (Adenylyl cyclase 5) [Source:UniProtKB/Swiss-Prot;Acc:O95622][hgnc]
Otolemur_garnettiione2one ENSOGAG00000014543Adenylate cyclase type 5 (EC 4.6.1.1) (Adenylate cyclase type V) (ATP pyrophosphate-lyase 5) (Adenylyl cyclase 5) [Source:UniProtKB/Swiss-Prot;Acc:O95622][hgnc]
Microcebus_murinusone2one ENSMICG00000008158Adenylate cyclase type 5 (EC 4.6.1.1) (Adenylate cyclase type V) (ATP pyrophosphate-lyase 5) (Adenylyl cyclase 5) [Source:UniProtKB/Swiss-Prot;Acc:O95622][hgnc]
Tursiops_truncatusone2one ENSTTRG00000000594Adenylate cyclase type 5 (EC 4.6.1.1) (Adenylate cyclase type V) (ATP pyrophosphate-lyase 5) (Adenylyl cyclase 5) [Source:UniProtKB/Swiss-Prot;Acc:O95622][hgnc]
Pteropus_vampyrusone2one ENSPVAG00000017852Adenylate cyclase type 5 (EC 4.6.1.1) (Adenylate cyclase type V) (ATP pyrophosphate-lyase 5) (Adenylyl cyclase 5) [Source:UniProtKB/Swiss-Prot;Acc:O95622][hgnc]
Spermophilus_tridecemlineatusone2one ENSSTOG00000000043Adenylate cyclase type 5 (EC 4.6.1.1) (Adenylate cyclase type V) (ATP pyrophosphate-lyase 5) (Adenylyl cyclase 5) [Source:UniProtKB/Swiss-Prot;Acc:O95622][hgnc]
Felis_catusone2one ENSFCAG00000000939Adenylate cyclase type 5 (EC 4.6.1.1) (Adenylate cyclase type V) (ATP pyrophosphate-lyase 5) (Adenylyl cyclase 5) [Source:UniProtKB/Swiss-Prot;Acc:O95622][hgnc]
Canis_familiarisone2one ENSCAFG00000012084Adenylate cyclase type 5 (EC 4.6.1.1) (Adenylate cyclase type V) (ATP pyrophosphate-lyase 5) (Adenylyl cyclase 5) (Ca(2+)-inhibitable adenylyl cyclase). [Source:UniProtKB/Swiss-Prot;Acc:P30803][hgnc]
Loxodonta_africanaone2one ENSLAFG00000001469Adenylate cyclase type 5 (EC 4.6.1.1) (Adenylate cyclase type V) (ATP pyrophosphate-lyase 5) (Adenylyl cyclase 5) [Source:UniProtKB/Swiss-Prot;Acc:O95622][hgnc]
Tarsius_syrichtaone2one ENSTSYG00000004991Adenylate cyclase type 5 (EC 4.6.1.1) (Adenylate cyclase type V) (ATP pyrophosphate-lyase 5) (Adenylyl cyclase 5) [Source:UniProtKB/Swiss-Prot;Acc:O95622][hgnc]
Bos_taurusone2one ENSBTAG00000018777Adenylate cyclase type 5 (EC 4.6.1.1) (Adenylate cyclase type V) (ATP pyrophosphate-lyase 5) (Adenylyl cyclase 5) [Source:UniProtKB/Swiss-Prot;Acc:O95622][hgnc]ADCY5
Procavia_capensisone2one ENSPCAG00000012201Adenylate cyclase type 5 (EC 4.6.1.1) (Adenylate cyclase type V) (ATP pyrophosphate-lyase 5) (Adenylyl cyclase 5) [Source:UniProtKB/Swiss-Prot;Acc:O95622][hgnc]
Echinops_telfairione2one ENSETEG00000018833Adenylate cyclase type 5 (EC 4.6.1.1) (Adenylate cyclase type V) (ATP pyrophosphate-lyase 5) (Adenylyl cyclase 5) [Source:UniProtKB/Swiss-Prot;Acc:O95622][hgnc]
Dipodomys_ordiione2one ENSDORG00000000320Adenylate cyclase type 5 (EC 4.6.1.1) (Adenylate cyclase type V) (ATP pyrophosphate-lyase 5) (Adenylyl cyclase 5) [Source:UniProtKB/Swiss-Prot;Acc:P84309][hgnc]
Ochotona_princepsone2one ENSOPRG00000014021Adenylate cyclase type 5 (EC 4.6.1.1) (Adenylate cyclase type V) (ATP pyrophosphate-lyase 5) (Adenylyl cyclase 5) [Source:UniProtKB/Swiss-Prot;Acc:O95622][hgnc]
Cavia_porcellusone2one ENSCPOG00000013929Adenylate cyclase type 5 (EC 4.6.1.1) (Adenylate cyclase type V) (ATP pyrophosphate-lyase 5) (Adenylyl cyclase 5) [Source:UniProtKB/Swiss-Prot;Acc:O95622][hgnc]
Mus_musculusone2one ENSMUSG00000022840Adenylate cyclase type 5 (EC 4.6.1.1) (Adenylate cyclase type V) (ATP pyrophosphate-lyase 5) (Adenylyl cyclase 5) [Source:UniProtKB/Swiss-Prot;Acc:P84309][hgnc]LOC100047385
Rattus_norvegicusone2one ENSRNOG00000002229Adenylate cyclase type 5 (EC 4.6.1.1) (Adenylate cyclase type V) (ATP pyrophosphate-lyase 5) (Adenylyl cyclase 5). [Source:UniProtKB/Swiss-Prot;Acc:Q04400][hgnc]Adcy5
Erinaceus_europaeusone2one ENSEEUG00000014485Adenylate cyclase type 5 (EC 4.6.1.1) (Adenylate cyclase type V) (ATP pyrophosphate-lyase 5) (Adenylyl cyclase 5) [Source:UniProtKB/Swiss-Prot;Acc:O95622][hgnc]
Monodelphis_domesticaone2one ENSMODG00000018333Adenylate cyclase type 5 (EC 4.6.1.1) (Adenylate cyclase type V) (ATP pyrophosphate-lyase 5) (Adenylyl cyclase 5) [Source:UniProtKB/Swiss-Prot;Acc:O95622][hgnc]
Gallus_gallusone2one ENSGALG00000011699adenylate cyclase 5 [Source:RefSeq_peptide;Acc:NP_989962][hgnc]ADCY5
Ciona_savignyione2many ENSCSAVG00000005675[hgnc]