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Summary sheet information for Effector 'Adenylate cyclase 6-Homo sapiens'
Name Adenylate cyclase 6-Homo sapiens
Description RecName: Full=Adenylate cyclase type 6; EC=4.6.1.1;AltName: Full=Adenylate cyclase type VI;AltName: Full=ATP pyrophosphate-lyase 6;AltName: Full=Adenylyl cyclase 6;AltName: Full=Ca(2+)-inhibitable adenylyl cyclase
Class
Family Cyclases
Sub_family Adenylate cyclases
type Adenylate cyclase 6
Protein features link Protein Information from Dasty2 DAS Client
GPCR, G-protein, Effector interaction Visualizaton of GPCR, G-protein, Effector interaction at protein level
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Genes
Gene Location:
Chromosome: 12
Gene Start: 47446248
Gene End: 47469087
Ensembl Contig View

Ensembl Genes:
ENSG00000174233

EMBL:
EMBL ID  Description
AB007882  Homo sapiens KIAA0422 mRNA, partial cds.
AF250226  Homo sapiens adenylyl cyclase type VI mRNA, complete cds.
AF250227  Homo sapiens adenylyl cyclase type VI gene, partial cds.
BC064923  Homo sapiens adenylate cyclase 6, mRNA (cDNA clone IMAGE:6141275).
U65474  Homo sapiens adenylyl cyclase type VI mRNA, partial cds.

EntrezGene:
ID  Description
ADCY6  adenylate cyclase 6

RefSeq DNA:
ID  Description
NM_015270  Homo sapiens adenylate cyclase 6 (ADCY6), transcript variant 1, mRNA.
NM_020983  Homo sapiens adenylate cyclase 6 (ADCY6), transcript variant 2, mRNA.

UniGene:
ID  Description
Hs.525401  KIAA0422
Hs.694408  Adenylate cyclase 6 isoform b variant, clone: COL06070

Proteins
Ensembl Proteins:
ENSP00000350536; ENSP00000311405; ENSP00000378636

Entrez Proteins:
AAD00122.1; AAF82478.1; AAF82479.1; AAH64923.1; BAA24852.2

RefSeq Proteins:
ID  Description
NP_056085  adenylate cyclase 6 isoform a [Homo sapiens].
NP_066193  adenylate cyclase 6 isoform b [Homo sapiens].

UniProt:
ID  Description
O43306-2  UNKNOWN
Q6LCE1  SubName: Full=Adenylyl cyclase type VI; Flags: Fragment;
Q9NR74  SubName: Full=Adenylyl cyclase type VI; Flags: Fragment;
Q9UDB0  SubName: Full=Type VI adenylyl cyclase; EC=4.6.1.1; Flags: Fragment;
O43306  RecName: Full=Adenylate cyclase type 6; EC=4.6.1.1; AltName: Full=Adenylate cyclase type VI; AltName: Full=ATP pyrophosphate-lyase 6; AltName: Full=Adenylyl cyclase 6; AltName: Full=Ca(2+)-inhibitable adenylyl cyclase;

Domains
SMART:
- Hyperlink to SMART; - Hyperlink to ENSEMBL
     Adenylate cyclase 6-Homo sapiens    

InterPro:
ID  Name
IPR009398  Aden_cycl_like
IPR001054  A/G_cyclase

Pfam:
ID  Description
Guanylate_cyc  Adenylate and Guanylate cyclase catalytic domain
Guanylate_cyc  Adenylate and Guanylate cyclase catalytic domain
DUF1053  Domain of Unknown Function (DUF1053)

Structure
PDB:
ID

HSSP:
ID  Description
1ab8  LYASE
1azs  COMPLEX (LYASE/HYDROLASE)
1cjk  LYASE/LYASE/SIGNALING PROTEIN
1cjt  LYASE/LYASE/SIGNALING PROTEIN
1cju  LYASE/LYASE/SIGNALING PROTEIN
1cjv  LYASE/LYASE/SIGNALING PROTEIN
1cs4  LYASE/LYASE/SIGNALING PROTEIN
1cul  LYASE/LYASE/SIGNALING PROTEIN
1tl7  LYASE
1u0h  LYASE
1yk9  LYASE
2gvd  LYASE
2gvz  LYASE
3c14  LYASE/LYASE INHIBITOR
3c15  LYASE/LYASE INHIBITOR
3c16  LYASE/LYASE INHIBITOR
3et6  LYASE

PSSH:
ID  Description
Q6LCE1  UNKNOWN
Q9UDB0  UNKNOWN
O43306  UNKNOWN

Diseases
OMIM:
OMIM ID  Name  Alt Name
600294  ADENYLATE CYCLASE 6; ADCY6   ADENYLYL CYCLASE 6

Gene Ontology
GO:
GO ID  Description
GO:0000287  magnesium ion binding
GO:0004016  adenylate cyclase activity
GO:0006171  cAMP biosynthetic process
GO:0007242  intracellular signaling cascade
GO:0009190  cyclic nucleotide biosynthetic process
GO:0016020  membrane
GO:0016021  integral to membrane
GO:0016849  phosphorus-oxygen lyase activity

Pathway
KEGG:
KEGG PATHWAY ID  Name
hsa04062  Chemokine signaling pathway
hsa05414  Dilated cardiomyopathy
hsa04540  Gap junction
hsa04912  GnRH signaling pathway
hsa04916  Melanogenesis
hsa04114  Oocyte meiosis
hsa04914  Progesterone-mediated oocyte maturation
hsa00230  Purine metabolism
hsa04742  Taste transduction
hsa04270  Vascular smooth muscle contraction
hsa04962  Vasopressin-regulated water reabsorption

Panther:
ID  Description
P00026  Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
P05731  GABA-B receptor II signaling
P00019  Endothelin signaling pathway
P00031  Inflammation mediated by chemokine and cytokine signaling pathway

Chemicals
DrugBank:
ID  Name  Synonyms
HMDB:
ID  Name  Synonyms
HMDB00538   Adenosine triphosphate   5'-(tetrahydrogen triphosphate) Adenosine; 5'-ATP; ATP; Adenosine 5'-triphosphate; Adenosine 5'-triphosphorate; Adenosine 5'-triphosphoric acid; Adenosine triphosphate; Adenosine triphosphic acid; Adenylpyrophosphorate; Adenylpyrophosphoric acid; Adephos; Adetol; Adynol; Atipi; Atriphos; Cardenosine; Fosfobion; Glucobasin; Myotriphos; Phosphobion; Striadyne; Triadenyl; Triphosphaden; Triphosphoric acid adenosine ester
HMDB00058   Cyclic AMP   Cyclic AMP; 3'5'-cyclic AMP; 6-(6-Amino-9H-purin-9-yl)tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinine-2,7-diol 2-oxide; Acrasin; Adenosine 3',5'-cyclic monophosphate; Adenosine 3',5'-cyclic phosphate; Adenosine 3',5'-cyclophosphate; Adenosine 3',5'-monophosphate; Adenosine 3,5'-cyclic monophosphorate; Adenosine 3,5'-cyclic monophosphoric acid; Adenosine cyclic monophosphate; Cyclic 3',5'-AMP; Cyclic 3',5'-adenylate; Cyclic 3',5'-adenylic acid; Cyclic adenosine 3',5'-phosphate; adenosine cyclic-monophosphate; adenosine-cyclic-phosphate; adenosine-cyclic-phosphoric-acid; cAMP
HMDB00250   Pyrophosphate   (4-)Diphosphoric acid ion; (P2O74-)Diphosphate; Diphosphate; Pyrometaphosphate; Pyrophosphate; Pyrophosphate tetraanion; Pyrophosphate(4-) ion; Pyrophosphic acid
Orthology
Orthology Relations:
Gene Gene Description Organism Orthology type Orthologs Orthologs Description
ENSG00000174233 Adenylate cyclase type 6 (EC 4.6.1.1) (Adenylate cyclase type VI) (ATP pyrophosphate-lyase 6) (Adenylyl cyclase 6) (Ca(2+)-inhibitable adenylyl cyclase) [Source:UniProtKB/Swiss-Prot;Acc:O43306] Aedes_aegyptione2many AAEL001034adenylate cyclase type vi[hgnc]
Ciona_savignyione2many ENSCSAVG00000005675[hgnc]
Pan_troglodytesone2one ENSPTRG00000004885Adenylate cyclase type 6 (EC 4.6.1.1) (Adenylate cyclase type VI) (ATP pyrophosphate-lyase 6) (Adenylyl cyclase 6) (Ca(2+)-inhibitable adenylyl cyclase) [Source:UniProtKB/Swiss-Prot;Acc:O43306][hgnc]
Pongo_pygmaeusone2one ENSPPYG00000004466Adenylate cyclase type 6 (EC 4.6.1.1) (Adenylate cyclase type VI) (ATP pyrophosphate-lyase 6) (Adenylyl cyclase 6) (Ca(2+)-inhibitable adenylyl cyclase) [Source:UniProtKB/Swiss-Prot;Acc:O43306][hgnc]
Macaca_mulattaone2one ENSMMUG00000006253Adenylate cyclase type 6 (EC 4.6.1.1) (Adenylate cyclase type VI) (ATP pyrophosphate-lyase 6) (Adenylyl cyclase 6) (Ca(2+)-inhibitable adenylyl cyclase) [Source:UniProtKB/Swiss-Prot;Acc:O43306][hgnc]
Microcebus_murinusone2one ENSMICG00000011825Adenylate cyclase type 6 (EC 4.6.1.1) (Adenylate cyclase type VI) (ATP pyrophosphate-lyase 6) (Adenylyl cyclase 6) (Ca(2+)-inhibitable adenylyl cyclase) [Source:UniProtKB/Swiss-Prot;Acc:O43306][hgnc]
Equus_caballusone2one ENSECAG00000022288Adenylate cyclase type 6 (EC 4.6.1.1) (Adenylate cyclase type VI) (ATP pyrophosphate-lyase 6) (Adenylyl cyclase 6) (Ca(2+)-inhibitable adenylyl cyclase) [Source:UniProtKB/Swiss-Prot;Acc:O43306][hgnc]LOC100051295
Tupaia_belangerione2one ENSTBEG00000017125Adenylate cyclase type 6 (EC 4.6.1.1) (Adenylate cyclase type VI) (ATP pyrophosphate-lyase 6) (Adenylyl cyclase 6) (Ca(2+)-inhibitable adenylyl cyclase) [Source:UniProtKB/Swiss-Prot;Acc:O43306][hgnc]
Pteropus_vampyrusone2one ENSPVAG00000009814Adenylate cyclase type 6 (EC 4.6.1.1) (Adenylate cyclase type VI) (ATP pyrophosphate-lyase 6) (Adenylyl cyclase 6) (Ca(2+)-inhibitable adenylyl cyclase) [Source:UniProtKB/Swiss-Prot;Acc:O43306][hgnc]
Tarsius_syrichtaone2one ENSTSYG00000014642Adenylate cyclase type 6 (EC 4.6.1.1) (Adenylate cyclase type VI) (ATP pyrophosphate-lyase 6) (Adenylyl cyclase 6) (Ca(2+)-inhibitable adenylyl cyclase) [Source:UniProtKB/Swiss-Prot;Acc:O43306][hgnc]
Tursiops_truncatusone2one ENSTTRG00000011289Adenylate cyclase type 6 (EC 4.6.1.1) (Adenylate cyclase type VI) (ATP pyrophosphate-lyase 6) (Adenylyl cyclase 6) (Ca(2+)-inhibitable adenylyl cyclase) [Source:UniProtKB/Swiss-Prot;Acc:O43306][hgnc]
Myotis_lucifugusone2one ENSMLUG00000010943Adenylate cyclase type 6 (EC 4.6.1.1) (Adenylate cyclase type VI) (ATP pyrophosphate-lyase 6) (Adenylyl cyclase 6) (Ca(2+)-inhibitable adenylyl cyclase) [Source:UniProtKB/Swiss-Prot;Acc:O43306][hgnc]
Felis_catusone2one ENSFCAG00000000079Adenylate cyclase type 6 (EC 4.6.1.1) (Adenylate cyclase type VI) (ATP pyrophosphate-lyase 6) (Adenylyl cyclase 6) (Ca(2+)-inhibitable adenylyl cyclase) [Source:UniProtKB/Swiss-Prot;Acc:O43306][hgnc]
Spermophilus_tridecemlineatusone2one ENSSTOG00000004149Adenylate cyclase type 6 (EC 4.6.1.1) (Adenylate cyclase type VI) (ATP pyrophosphate-lyase 6) (Adenylyl cyclase 6) (Ca(2+)-inhibitable adenylyl cyclase) [Source:UniProtKB/Swiss-Prot;Acc:O43306][hgnc]
Canis_familiarisone2one ENSCAFG00000008907Adenylate cyclase type 6 (EC 4.6.1.1) (Adenylate cyclase type VI) (ATP pyrophosphate-lyase 6) (Adenylyl cyclase 6) (Ca(2+)-inhibitable adenylyl cyclase). [Source:UniProtKB/Swiss-Prot;Acc:P30804][hgnc]Adcy6
Loxodonta_africanaone2one ENSLAFG00000014218Adenylate cyclase type 6 (EC 4.6.1.1) (Adenylate cyclase type VI) (ATP pyrophosphate-lyase 6) (Adenylyl cyclase 6) (Ca(2+)-inhibitable adenylyl cyclase) [Source:UniProtKB/Swiss-Prot;Acc:O43306][hgnc]
Oryctolagus_cuniculusone2one ENSOCUG00000007394Adenylate cyclase type 6 (EC 4.6.1.1) (Adenylate cyclase type VI) (ATP pyrophosphate-lyase 6) (Adenylyl cyclase 6) (Ca(2+)-inhibitable adenylyl cyclase) [Source:UniProtKB/Swiss-Prot;Acc:O43306][hgnc]
Dipodomys_ordiione2one ENSDORG00000005171Adenylate cyclase type 6 (EC 4.6.1.1) (Adenylate cyclase type VI) (ATP pyrophosphate-lyase 6) (Adenylyl cyclase 6) (Ca(2+)-inhibitable adenylyl cyclase) [Source:UniProtKB/Swiss-Prot;Acc:Q01341][hgnc]
Bos_taurusone2one ENSBTAG00000005464Adenylate cyclase type 6 (EC 4.6.1.1) (Adenylate cyclase type VI) (ATP pyrophosphate-lyase 6) (Adenylyl cyclase 6) (Ca(2+)-inhibitable adenylyl cyclase) [Source:UniProtKB/Swiss-Prot;Acc:O43306][hgnc]ADCY6
Procavia_capensisone2one ENSPCAG00000008998Adenylate cyclase type 6 (EC 4.6.1.1) (Adenylate cyclase type VI) (ATP pyrophosphate-lyase 6) (Adenylyl cyclase 6) (Ca(2+)-inhibitable adenylyl cyclase) [Source:UniProtKB/Swiss-Prot;Acc:O43306][hgnc]
Otolemur_garnettiione2one ENSOGAG00000016801Adenylate cyclase type 6 (EC 4.6.1.1) (Adenylate cyclase type VI) (ATP pyrophosphate-lyase 6) (Adenylyl cyclase 6) (Ca(2+)-inhibitable adenylyl cyclase) [Source:UniProtKB/Swiss-Prot;Acc:O43306][hgnc]
Ochotona_princepsone2one ENSOPRG00000007130Adenylate cyclase type 6 (EC 4.6.1.1) (Adenylate cyclase type VI) (ATP pyrophosphate-lyase 6) (Adenylyl cyclase 6) (Ca(2+)-inhibitable adenylyl cyclase) [Source:UniProtKB/Swiss-Prot;Acc:O43306][hgnc]
Echinops_telfairione2one ENSETEG00000015805Adenylate cyclase type 6 (EC 4.6.1.1) (Adenylate cyclase type VI) (ATP pyrophosphate-lyase 6) (Adenylyl cyclase 6) (Ca(2+)-inhibitable adenylyl cyclase) [Source:UniProtKB/Swiss-Prot;Acc:O43306][hgnc]
Erinaceus_europaeusone2one ENSEEUG00000013854Adenylate cyclase type 6 (EC 4.6.1.1) (Adenylate cyclase type VI) (ATP pyrophosphate-lyase 6) (Adenylyl cyclase 6) (Ca(2+)-inhibitable adenylyl cyclase) [Source:UniProtKB/Swiss-Prot;Acc:O43306][hgnc]
Rattus_norvegicusone2one ENSRNOG00000011587Adenylate cyclase type 6 (EC 4.6.1.1) (Adenylate cyclase type VI) (ATP pyrophosphate-lyase 6) (Adenylyl cyclase 6) (Ca(2+)-inhibitable adenylyl cyclase) (ACVI). [Source:UniProtKB/Swiss-Prot;Acc:Q03343][hgnc]Adcy6
Mus_musculusone2one ENSMUSG00000022994Adenylate cyclase type 6 (EC 4.6.1.1) (Adenylate cyclase type VI) (ATP pyrophosphate-lyase 6) (Adenylyl cyclase 6) (Ca(2+)-inhibitable adenylyl cyclase) [Source:UniProtKB/Swiss-Prot;Acc:Q01341][hgnc]Adcy6
Sorex_araneusone2one ENSSARG00000005472Adenylate cyclase type 6 (EC 4.6.1.1) (Adenylate cyclase type VI) (ATP pyrophosphate-lyase 6) (Adenylyl cyclase 6) (Ca(2+)-inhibitable adenylyl cyclase) [Source:UniProtKB/Swiss-Prot;Acc:O43306][hgnc]
Ornithorhynchus_anatinusone2one ENSOANG00000008088Adenylate cyclase type 6 (EC 4.6.1.1) (Adenylate cyclase type VI) (ATP pyrophosphate-lyase 6) (Adenylyl cyclase 6) (Ca(2+)-inhibitable adenylyl cyclase) [Source:UniProtKB/Swiss-Prot;Acc:O43306][hgnc]100081118
Gasterosteus_aculeatusone2many ENSGACG00000003042Adenylate cyclase type 6 (EC 4.6.1.1) (Adenylate cyclase type VI) (ATP pyrophosphate-lyase 6) (Adenylyl cyclase 6) (Ca(2+)-inhibitable adenylyl cyclase) [Source:UniProtKB/Swiss-Prot;Acc:O43306][hgnc]
Gasterosteus_aculeatusone2many ENSGACG00000008575Adenylate cyclase type 6 (EC 4.6.1.1) (Adenylate cyclase type VI) (ATP pyrophosphate-lyase 6) (Adenylyl cyclase 6) (Ca(2+)-inhibitable adenylyl cyclase) [Source:UniProtKB/Swiss-Prot;Acc:O43306][hgnc]
Oryzias_latipesone2many ENSORLG00000012382Adenylate cyclase type 6 (EC 4.6.1.1) (Adenylate cyclase type VI) (ATP pyrophosphate-lyase 6) (Adenylyl cyclase 6) (Ca(2+)-inhibitable adenylyl cyclase) [Source:UniProtKB/Swiss-Prot;Acc:O43306][hgnc]
Oryzias_latipesone2many ENSORLG00000006969Adenylate cyclase type 6 (EC 4.6.1.1) (Adenylate cyclase type VI) (ATP pyrophosphate-lyase 6) (Adenylyl cyclase 6) (Ca(2+)-inhibitable adenylyl cyclase) [Source:UniProtKB/Swiss-Prot;Acc:O43306][hgnc]
Danio_rerioone2one ENSDARG00000027797Adenylate cyclase type 6 (EC 4.6.1.1) (Adenylate cyclase type VI) (ATP pyrophosphate-lyase 6) (Adenylyl cyclase 6) (Ca(2+)-inhibitable adenylyl cyclase) [Source:UniProtKB/Swiss-Prot;Acc:O43306][hgnc]
Takifugu_rubripesone2many ENSTRUG00000000813Adenylyl cyclase type VI. [Source:UniProtKB/TrEMBL;Acc:O57654][hgnc]
Takifugu_rubripesone2many ENSTRUG00000015455Adenylate cyclase type 6 (EC 4.6.1.1) (Adenylate cyclase type VI) (ATP pyrophosphate-lyase 6) (Adenylyl cyclase 6) (Ca(2+)-inhibitable adenylyl cyclase) [Source:UniProtKB/Swiss-Prot;Acc:O43306][hgnc]
Tetraodon_nigroviridisone2one ENSTNIG00000015097Adenylate cyclase type 6 (EC 4.6.1.1) (Adenylate cyclase type VI) (ATP pyrophosphate-lyase 6) (Adenylyl cyclase 6) (Ca(2+)-inhibitable adenylyl cyclase) [Source:UniProtKB/Swiss-Prot;Acc:O43306][hgnc]
Xenopus_tropicalisapprent_one2one ENSXETG00000009789Adenylate cyclase type 6 (EC 4.6.1.1) (Adenylate cyclase type VI) (ATP pyrophosphate-lyase 6) (Adenylyl cyclase 6) (Ca(2+)-inhibitable adenylyl cyclase) [Source:UniProtKB/Swiss-Prot;Acc:O43306][hgnc]
Ciona_intestinalisone2many ENSCING00000000292Adenylate cyclase (Fragment). [Source:UniProtKB/TrEMBL;Acc:Q69HQ2][hgnc]