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Summary sheet information for Effector 'Tubulin-Homo sapiens-18'
Name Tubulin-Homo sapiens-18
Description RecName: Full=Tubulin beta-6 chain
Class
Family Tubulins
Sub_family Tubulins
type Tubulin
Protein features link Protein Information from Dasty2 DAS Client
GPCR, G-protein, Effector interaction Visualizaton of GPCR, G-protein, Effector interaction at protein level
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Genes
Gene Location:
Chromosome: 18
Gene Start: 12298257
Gene End: 12316567
Ensembl Contig View

Ensembl Genes:
ENSG00000176014

EMBL:
EMBL ID  Description
AK022340  Homo sapiens cDNA FLJ12278 fis, clone MAMMA1001735, highly similar to TUBULIN BETA-5 CHAIN.
BC002654  Homo sapiens tubulin, beta 6, mRNA (cDNA clone MGC:4083 IMAGE:3605559), complete cds.
BC111374  Homo sapiens tubulin, beta 6, mRNA (cDNA clone MGC:132410 IMAGE:7503364), complete cds.

EntrezGene:
ID  Description
TUBB6  tubulin, beta 6

RefSeq DNA:
ID  Description
NM_032525  Homo sapiens tubulin, beta 6 (TUBB6), mRNA.

UniGene:
ID  Description
Hs.193491  CDNA FLJ35358 fis, clone PUAEN2000497, highly similar to Tubulin beta-6 chain

Proteins
Ensembl Proteins:
ENSP00000318697

Entrez Proteins:
AAH02654.1; AAI11375.1; BAB14016.1

RefSeq Proteins:
ID  Description
NP_115914  tubulin, beta 6 [Homo sapiens].

UniProt:
ID  Description
Q2NKY5  SubName: Full=TUBB6 protein;
Q9BUF5  RecName: Full=Tubulin beta-6 chain;

Domains
SMART:
- Hyperlink to SMART; - Hyperlink to ENSEMBL
     Tubulin-Homo sapiens-18    

InterPro:
ID  Name
IPR017975  Tubulin_CS
IPR013838  Beta-tubulin_BS
IPR002453  Beta_tubulin
IPR003008  Tubulin_FtsZ
IPR000217  Tubulin
IPR008280  Tub_FtsZ_C
IPR000158  Cell_division_FtsZ_N

Pfam:
ID  Description
Tubulin  Tubulin/FtsZ family, GTPase domain
Tubulin_C  Tubulin/FtsZ family, C-terminal domain

Structure
PDB:
ID

HSSP:
ID  Description
1ffx  STRUCTURAL PROTEIN
1ia0  TRANSPORT PROTEIN
1jff  STRUCTURAL PROTEIN
1sa0  CELL CYCLE
1sa1  CELL CYCLE
1tub  MICROTUBULES
1tvk  CELL CYCLE, STRUCTURAL PROTEIN
1z2b  CELL CYCLE
1z5v  STRUCTURAL PROTEIN
1z5w  STRUCTURAL PROTEIN
2bto  CYTOSKELETAL PROTEIN
2btq  CYTOSKELETAL PROTEIN/COMPLEX
2hxf  TRANSPORT PROTEIN
2hxh  TRANSPORT PROTEIN
2p4n  TRANSPORT PROTEIN
3cb2  STRUCTURAL PROTEIN, HYDROLASE
3dco  MOTOR PROTEIN
3du7  CELL CYCLE
3e22  CELL CYCLE
3edl  STRUCTURAL PROTEIN

PSSH:
ID  Description
Q2NKY5  UNKNOWN

Diseases
OMIM:
OMIM ID  Name  Alt Name

Gene Ontology
GO:
GO ID  Description
GO:0000166  nucleotide binding
GO:0003924  GTPase activity
GO:0005198  structural molecule activity
GO:0005525  GTP binding
GO:0005737  cytoplasm
GO:0005874  microtubule
GO:0007017  microtubule-based process
GO:0007018  microtubule-based movement
GO:0043234  protein complex
GO:0051258  protein polymerization

Pathway
KEGG:
KEGG PATHWAY ID  Name
hsa04540  Gap junction
hsa05130  Pathogenic Escherichia coli infection

Panther:
ID  Description
P00016  Cytoskeletal regulation by Rho GTPase
P00029  Huntington disease

Chemicals
DrugBank:
ID  Name  Synonyms
HMDB:
ID  Name  Synonyms
Orthology
Orthology Relations:
Gene Gene Description Organism Orthology type Orthologs Orthologs Description
ENSG00000176014 Tubulin beta-6 chain [Source:UniProtKB/Swiss-Prot;Acc:Q9BUF5] Xenopus_tropicalisone2one ENSXETG00000019687MGC79632 protein. [Source:UniProtKB/TrEMBL;Acc:Q66JE8][hgnc]
Pan_troglodytesone2one ENSPTRG00000009878Tubulin beta (Fragment). [Source:UniProtKB/TrEMBL;Acc:Q6J9K1][hgnc]TUBB6
Pongo_pygmaeusone2one ENSPPYG00000008991Tubulin beta-6 chain [Source:UniProtKB/Swiss-Prot;Acc:Q9BUF5][hgnc]
Ochotona_princepsone2one ENSOPRG00000016816Tubulin beta-6 chain [Source:UniProtKB/Swiss-Prot;Acc:Q9BUF5][hgnc]
Felis_catusone2one ENSFCAG00000006465Tubulin beta-6 chain [Source:UniProtKB/Swiss-Prot;Acc:Q9BUF5][hgnc]
Sorex_araneusone2one ENSSARG00000009965Tubulin beta-6 chain [Source:UniProtKB/Swiss-Prot;Acc:Q9BUF5][hgnc]
Canis_familiarisone2one ENSCAFG00000018832Tubulin beta-6 chain [Source:UniProtKB/Swiss-Prot;Acc:Q9BUF5][hgnc]TUBB6
Tarsius_syrichtaone2one ENSTSYG00000012620Tubulin beta-6 chain [Source:UniProtKB/Swiss-Prot;Acc:Q9BUF5][hgnc]
Rattus_norvegicusone2one ENSRNOG00000018371tubulin, beta 6 [Source:RefSeq_peptide;Acc:NP_001020846][hgnc]Tubb6
Tupaia_belangerione2one ENSTBEG00000009499Tubulin beta-6 chain [Source:UniProtKB/Swiss-Prot;Acc:Q9BUF5][hgnc]
Mus_musculusone2one ENSMUSG00000001473Tubulin beta-6 chain [Source:UniProtKB/Swiss-Prot;Acc:Q922F4][hgnc]Tubb6
Equus_caballusone2one ENSECAG00000016535Tubulin beta-6 chain [Source:UniProtKB/Swiss-Prot;Acc:Q9BUF5][hgnc]LOC100058421
Microcebus_murinusone2one ENSMICG00000000129Tubulin beta-6 chain [Source:UniProtKB/Swiss-Prot;Acc:Q9BUF5][hgnc]
Pteropus_vampyrusone2one ENSPVAG00000001860Tubulin beta-6 chain [Source:UniProtKB/Swiss-Prot;Acc:Q9BUF5][hgnc]
Loxodonta_africanaone2one ENSLAFG00000016571Tubulin beta-6 chain [Source:UniProtKB/Swiss-Prot;Acc:Q9BUF5][hgnc]
Dasypus_novemcinctusone2one ENSDNOG00000006449Tubulin beta-6 chain [Source:UniProtKB/Swiss-Prot;Acc:Q9BUF5][hgnc]
Tursiops_truncatusone2one ENSTTRG00000003703Tubulin beta-6 chain [Source:UniProtKB/Swiss-Prot;Acc:Q9BUF5][hgnc]
Myotis_lucifugusone2one ENSMLUG00000016219Tubulin beta-6 chain [Source:UniProtKB/Swiss-Prot;Acc:Q9BUF5][hgnc]
Macaca_mulattaone2one ENSMMUG00000032572Tubulin beta-6 chain [Source:UniProtKB/Swiss-Prot;Acc:Q9BUF5][hgnc]
Procavia_capensisone2one ENSPCAG00000014295Tubulin beta-6 chain [Source:UniProtKB/Swiss-Prot;Acc:Q9BUF5][hgnc]
Dipodomys_ordiione2one ENSDORG00000005346Tubulin beta-6 chain [Source:UniProtKB/Swiss-Prot;Acc:Q922F4][hgnc]
Ornithorhynchus_anatinusone2one ENSOANG00000003049Tubulin beta-6 chain [Source:UniProtKB/Swiss-Prot;Acc:Q9BUF5][hgnc]100089091
Monodelphis_domesticaone2one ENSMODG00000003363Tubulin beta-6 chain [Source:UniProtKB/Swiss-Prot;Acc:Q9BUF5][hgnc]
Tetraodon_nigroviridisone2one ENSTNIG00000013517Tubulin beta-6 chain [Source:UniProtKB/Swiss-Prot;Acc:Q9BUF5][hgnc]
Gasterosteus_aculeatusone2one ENSGACG00000002049Tubulin beta-6 chain [Source:UniProtKB/Swiss-Prot;Acc:Q9BUF5][hgnc]
Gallus_gallusone2one ENSGALG00000000059Gallus gallus tubulin, beta 6 (TUBB6), mRNA. [Source:RefSeq_dna;Acc:NM_001031012][hgnc]LOC776519
Takifugu_rubripesone2one ENSTRUG00000005300Tubulin beta-6 chain [Source:UniProtKB/Swiss-Prot;Acc:Q9BUF5][hgnc]
Oryzias_latipesone2one ENSORLG00000003475Tubulin beta-6 chain [Source:UniProtKB/Swiss-Prot;Acc:Q9BUF5][hgnc]
Danio_rerioone2one ENSDARG00000055649hypothetical protein LOC550458 [Source:RefSeq_peptide;Acc:NP_001017762][hgnc]LOC792245
Caenorhabditis_elegansone2many ZK154.3mec-7 encodes a beta-tubulin required for touch sensitivity along the body wall, and for normal levels of locomotor activity. it is strongly expressed in six touch receptor neurons, with weak expression in FLP, PVD, and BDU cells. [Source: WormBase][hgnc]mec-7
Saccharomyces_cerevisiaeone2many YFL037WTubulin beta chain (Beta-tubulin). [Source:UniProtKB/Swiss-Prot;Acc:P02557][hgnc]TUB2