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Summary sheet information for GPCR 'ANGIOTENSIN RECEPTORS_AT2_Homo sapiens'
Name ANGIOTENSIN RECEPTORS_AT2_Homo sapiens
Description RecName: Full=Type-2 angiotensin II receptor;AltName: Full=AT2
Class CLASS A
Family ANGIOTENSIN RECEPTORS
Sub_family AT2
type
Protein features link Protein Information from Dasty2 DAS Client
GPCR, G-protein, Effector interaction Visualizaton of GPCR, G-protein, Effector interaction at protein level
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Genes
Gene Location:
Chromosome: X
Gene Start: 115215986
Gene End: 115220248
Ensembl Contig View

Ensembl Genes:
ENSG00000180772

EMBL:
EMBL ID  Description
AK313927  Homo sapiens cDNA, FLJ94566, Homo sapiens angiotensin II receptor, type 2 (AGTR2), mRNA.
AL732602  Human DNA sequence from clone RP11-517D11 on chromosome X Contains the 3' end of a aldo-keto reductase family 1 member B1 (aldose reductase) (AKR1B1) pseudogene, a apoptosis inhibitor 5 (API5) pseudogene and the AGTR2 gene for type 2 angiotensin II receptor.
AY322542  Homo sapiens angiotensin II receptor type 2 gene, complete cds.
AY324607  Homo sapiens angiotensin receptor 2 (AGTR2) gene, complete cds.
AY359675  Homo sapiens ATGR2 gene, partial cds.
AY536522  Homo sapiens angiotensin receptor 2 (AGTR2) gene, complete cds.
BC095504  Homo sapiens angiotensin II receptor, type 2, mRNA (cDNA clone MGC:111714 IMAGE:6971944), complete cds.
CH471234  Homo sapiens 211000035830114 genomic scaffold, whole genome shotgun sequence.
CR541969  Homo sapiens full open reading frame cDNA clone RZPDo834H1034D for gene AGTR2, angiotensin II receptor, type 2; complete cds, without stopcodon.
L34579  Homo sapiens (clone HC1) angiotensin II type-2 receptor (AGTR2) gene, complete cds.
U10273  Human angiotensin II receptor type 2 subtype gene, complete cds.
U15592  Human angiotensin II type 2 receptor gene, complete cds.
U16957  Human angiotensin II type 2 receptor mRNA, complete cds.
U20860  Human angiotensin II type 2 receptor gene, complete cds.
U27478  Homo sapiens angiotensin II type 2 receptor (AT2) gene, partial cds.
X87723  H.sapiens mRNA for angiotensin ii type receptor, mRNA, 5' untranslated region

EntrezGene:
ID  Description
AGTR2  angiotensin II receptor, type 2

RefSeq DNA:
ID  Description
NM_000686  Homo sapiens angiotensin II receptor, type 2 (AGTR2), mRNA.

UniGene:
ID  Description
Hs.405348  Angiotensin II type 2 receptor
Hs.601592  Transcribed locus

Proteins
Ensembl Proteins:
ENSP00000378229; ENSP00000360973

Entrez Proteins:
AAA50762.1; AAA61794.1; AAA67753.1; AAA84900.1; AAA85851.1; AAA98990.1; AAH95504.1; AAP72969.1; AAP84355.1; AAQ62073.1; AAS45437.1; BAG36648.1; CAA61022.1; CAG46767.1; CAI40984.1; EAW51502.1

RefSeq Proteins:
ID  Description
NP_000677  angiotensin II receptor, type 2 [Homo sapiens].

UniProt:
ID  Description
B2R9V1  SubName: Full=cDNA, FLJ94566, Homo sapiens angiotensin II receptor, type 2 (AGTR2), mRNA (Angiotensin II receptor, type 2);
Q6UVH2  SubName: Full=ATGR2; Flags: Fragment;
P50052  RecName: Full=Type-2 angiotensin II receptor; AltName: Full=AT2;

Domains
SMART:
- Hyperlink to SMART; - Hyperlink to ENSEMBL

InterPro:
ID  Name
IPR000248  ATII_rcpt
IPR000147  ATII_AT2_rcpt
IPR017452  GPCR_Rhodpsn_supfam
IPR001186  BK_rcpt_B1
IPR000276  GPCR_Rhodpsn

Pfam:
ID  Description
7tm_1  7 transmembrane receptor (rhodopsin family)

Structure
PDB:
ID

HSSP:
ID  Description

PSSH:
ID  Description
P50052  UNKNOWN

Diseases
OMIM:
OMIM ID  Name  Alt Name
300034  ANGIOTENSIN II RECEPTOR, TYPE 2; AGTR2 MENTAL RETARDATION, X-LINKED 88, INCLUDED; MRX88, INCLUDED   UNKNOWN

Gene Ontology
GO:
GO ID  Description
GO:0001584  rhodopsin-like receptor activity
GO:0001974  blood vessel remodeling
GO:0001991  regulation of systemic arterial blood pressure by circulatory renin-angiotensin
GO:0002033  vasodilation by angiotensin involved in regulation of systemic arterial blood pressure
GO:0002035  brain renin-angiotensin system
GO:0004872  receptor activity
GO:0004945  angiotensin type II receptor activity
GO:0004947  bradykinin receptor activity
GO:0004983  neuropeptide Y receptor activity
GO:0005515  protein binding
GO:0005886  plasma membrane
GO:0005887  integral to plasma membrane
GO:0007186  G-protein coupled receptor protein signaling pathway
GO:0007199  G-protein signaling, coupled to cGMP nucleotide second messenger
GO:0007243  protein kinase cascade
GO:0007263  nitric oxide mediated signal transduction
GO:0007420  brain development
GO:0007596  blood coagulation
GO:0007610  behavior
GO:0008217  regulation of blood pressure
GO:0010459  negative regulation of heart rate
GO:0015057  thrombin receptor activity
GO:0016021  integral to membrane
GO:0016493  C-C chemokine receptor activity
GO:0030308  negative regulation of cell growth
GO:0032516  positive regulation of phosphoprotein phosphatase activity
GO:0043065  positive regulation of apoptosis
GO:0043537  negative regulation of blood vessel endothelial cell migration
GO:0045028  purinergic nucleotide receptor activity, G-protein coupled
GO:0045429  positive regulation of nitric oxide biosynthetic process
GO:0045909  positive regulation of vasodilation
GO:0048019  receptor antagonist activity
GO:0051000  positive regulation of nitric-oxide synthase activity
GO:0051387  negative regulation of nerve growth factor receptor signaling pathway

Pathway
KEGG:
KEGG PATHWAY ID  Name
hsa04080  Neuroactive ligand-receptor interaction
hsa04614  Renin-angiotensin system

Panther:
ID  Description

Chemicals
DrugBank:
ID  Name  Synonyms
HMDB:
ID  Name  Synonyms
Other GPCR resources
Links to other GPCR resources
GPCRDB | GPCR-OKB | GLIDA
Orthology
Orthology Relations:
Gene Gene Description Organism Orthology type Orthologs Orthologs Description
ENSG00000180772 Type-2 angiotensin II receptor (AT2) [Source:UniProtKB/Swiss-Prot;Acc:P50052] Pan_troglodytesone2one ENSPTRG00000028215Type-2 angiotensin II receptor (AT2) [Source:UniProtKB/Swiss-Prot;Acc:P50052][hgnc]AGTR2
Pongo_pygmaeusone2one ENSPPYG00000020654Type-2 angiotensin II receptor (AT2) [Source:UniProtKB/Swiss-Prot;Acc:P50052][hgnc]
Macaca_mulattaone2one ENSMMUG00000023420Type-2 angiotensin II receptor (AT2) [Source:UniProtKB/Swiss-Prot;Acc:P50052][hgnc]
Tarsius_syrichtaone2one ENSTSYG00000007517Type-2 angiotensin II receptor (AT2) [Source:UniProtKB/Swiss-Prot;Acc:P50052][hgnc]
Tursiops_truncatusone2one ENSTTRG00000000884Type-2 angiotensin II receptor (AT2) [Source:UniProtKB/Swiss-Prot;Acc:P50052][hgnc]
Spermophilus_tridecemlineatusone2one ENSSTOG00000012524Type-2 angiotensin II receptor (AT2) [Source:UniProtKB/Swiss-Prot;Acc:P50052][hgnc]
Equus_caballusone2one ENSECAG00000018905Type-2 angiotensin II receptor (AT2) [Source:UniProtKB/Swiss-Prot;Acc:P50052][hgnc]LOC100053878
Myotis_lucifugusone2one ENSMLUG00000004283Type-2 angiotensin II receptor (AT2) [Source:UniProtKB/Swiss-Prot;Acc:P50052][hgnc]
Oryctolagus_cuniculusone2one ENSOCUG00000012363Angiotensin receptor 2. [Source:UniProtKB/TrEMBL;Acc:Q8MKE9][hgnc]
Bos_taurusone2one ENSBTAG00000040386Angiotensin receptor 2 (Fragment). [Source:UniProtKB/TrEMBL;Acc:Q9N0J0][hgnc]AGTR2
Canis_familiarisone2one ENSCAFG00000018264Angiotensin II receptor type 2 (Fragment). [Source:UniProtKB/TrEMBL;Acc:Q3HTU1][hgnc]AGTR2
Erinaceus_europaeusone2one ENSEEUG00000012908Type-2 angiotensin II receptor (AT2) [Source:UniProtKB/Swiss-Prot;Acc:P50052][hgnc]
Pteropus_vampyrusone2one ENSPVAG00000011251Type-2 angiotensin II receptor (AT2) [Source:UniProtKB/Swiss-Prot;Acc:P50052][hgnc]
Loxodonta_africanaone2one ENSLAFG00000004752Type-2 angiotensin II receptor (AT2) [Source:UniProtKB/Swiss-Prot;Acc:P50052][hgnc]
Procavia_capensisone2one ENSPCAG00000001268Type-2 angiotensin II receptor (AT2) [Source:UniProtKB/Swiss-Prot;Acc:P50052][hgnc]
Mus_musculusone2one ENSMUSG00000068122Type-2 angiotensin II receptor (AT2) [Source:UniProtKB/Swiss-Prot;Acc:P35374][hgnc]Agtr2
Felis_catusone2one ENSFCAG00000014073Type-2 angiotensin II receptor (AT2) [Source:UniProtKB/Swiss-Prot;Acc:P50052][hgnc]
Monodelphis_domesticaone2one ENSMODG00000004897Type-2 angiotensin II receptor (AT2) [Source:UniProtKB/Swiss-Prot;Acc:P50052][hgnc]
Gallus_gallusone2one ENSGALG00000005936Type-2 angiotensin II receptor (AT2) [Source:UniProtKB/Swiss-Prot;Acc:P50052][hgnc]AGTR2
Xenopus_tropicalisone2one ENSXETG00000024696Type-2 angiotensin II receptor (AT2) [Source:UniProtKB/Swiss-Prot;Acc:P50052][hgnc]
Danio_rerioone2one ENSDARG00000035552hypothetical protein LOC503772 [Source:RefSeq_peptide;Acc:NP_001013368][hgnc]zgc:113016
Tetraodon_nigroviridisone2one ENSTNIG00000015777Type-2 angiotensin II receptor (AT2) [Source:UniProtKB/Swiss-Prot;Acc:P50052][hgnc]
Takifugu_rubripesone2one ENSTRUG00000007325Type-2 angiotensin II receptor (AT2) [Source:UniProtKB/Swiss-Prot;Acc:P50052][hgnc]
Gasterosteus_aculeatusone2one ENSGACG00000018540Type-2 angiotensin II receptor (AT2) [Source:UniProtKB/Swiss-Prot;Acc:P50052][hgnc]
Oryzias_latipesone2one ENSORLG00000008388Type-2 angiotensin II receptor (AT2) [Source:UniProtKB/Swiss-Prot;Acc:P50052][hgnc]