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Summary sheet information for GPCR 'MUSCARINIC ACETYLCHOLINE RECEPTORS_M2_Homo sapiens'
Name MUSCARINIC ACETYLCHOLINE RECEPTORS_M2_Homo sapiens
Description RecName: Full=Muscarinic acetylcholine receptor M2
Class CLASS A
Family MUSCARINIC ACETYLCHOLINE RECEPTORS
Sub_family M2
type
Protein features link Protein Information from Dasty2 DAS Client
GPCR, G-protein, Effector interaction Visualizaton of GPCR, G-protein, Effector interaction at protein level
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Genes
Gene Location:
Chromosome: 7
Gene Start: 136203939
Gene End: 136352311
Ensembl Contig View

Ensembl Genes:
ENSG00000181072

EMBL:
EMBL ID  Description
AB041391  Homo sapiens CHRM2 gene for muscarinic acetylcholine receptor m2, partial cds.
AF385588  Homo sapiens m2 muscarinic cholinergic receptor (CHRM2) mRNA, complete cds.
AF498916  Homo sapiens muscarinic acetylcholine receptor M2 (CHRM2) mRNA, complete cds.
AK290236  Homo sapiens cDNA FLJ77278 complete cds, highly similar to Homo sapiens cholinergic receptor, muscarinic 2 (CHRM2), transcript variant 4, mRNA.
AY034603  Homo sapiens muscarinic M2 receptor (CHRM2) mRNA, 5' UTR and partial cds; alternatively spliced.
AY034604  Homo sapiens muscarinic M2 receptor (CHRM2) mRNA, 5' UTR and partial cds; alternatively spliced.
AY034605  Homo sapiens muscarinic M2 receptor (CHRM2) mRNA, 5' UTR and partial cds; alternatively spliced.
AY219703  Homo sapiens muscarinic M2 receptor mRNA, partial cds, alternative transcript.
AY219704  Homo sapiens muscarinic M2 receptor mRNA, partial cds, alternative transcript.
AY219705  Homo sapiens muscarinic M2 receptor mRNA, partial cds, alternative transcript.
AY456128  Homo sapiens M2 muscarinic acetylcholine receptor (CHRM2) mRNA, 3' UTR and partial cds, alternatively spliced.
AY456129  Homo sapiens M2 muscarinic acetylcholine receptor (CHRM2) mRNA, 3' UTR and partial cds, alternatively spliced.
BC095547  Homo sapiens cholinergic receptor, muscarinic 2, mRNA (cDNA clone MGC:111772 IMAGE:6519221), complete cds.
BC106741  Homo sapiens cholinergic receptor, muscarinic 2, mRNA (cDNA clone MGC:120006 IMAGE:40017105), complete cds.
BC106742  Homo sapiens cholinergic receptor, muscarinic 2, mRNA (cDNA clone MGC:120007 IMAGE:40017106), complete cds.
CH236950  Homo sapiens chromosome 7 Scaffold04, whole genome shotgun sequence.
CH471070  Homo sapiens 211000035837192 genomic scaffold, whole genome shotgun sequence.
M16404  Human m2 muscarinic acetylcholine receptor gene.
X15264  Human gene for muscarinic acetylcholine receptor HM2

EntrezGene:
ID  Description
CHRM2  cholinergic receptor, muscarinic 2

RefSeq DNA:
ID  Description
NM_000739  Homo sapiens cholinergic receptor, muscarinic 2 (CHRM2), transcript variant 4, mRNA.
NM_001006626  Homo sapiens cholinergic receptor, muscarinic 2 (CHRM2), transcript variant 3, mRNA.
NM_001006627  Homo sapiens cholinergic receptor, muscarinic 2 (CHRM2), transcript variant 2, mRNA.
NM_001006628  Homo sapiens cholinergic receptor, muscarinic 2 (CHRM2), transcript variant 6, mRNA.
NM_001006629  Homo sapiens cholinergic receptor, muscarinic 2 (CHRM2), transcript variant 8, mRNA.
NM_001006630  Homo sapiens cholinergic receptor, muscarinic 2 (CHRM2), transcript variant 1, mRNA.
NM_001006631  Homo sapiens cholinergic receptor, muscarinic 2 (CHRM2), transcript variant 5, mRNA.
NM_001006632  Homo sapiens cholinergic receptor, muscarinic 2 (CHRM2), transcript variant 7, mRNA.

UniGene:
ID  Description
Hs.535891  Muscarinic M2 receptor (CHRM2) mRNA, 5' UTR and partial cds; alternatively spliced

Proteins
Ensembl Proteins:
ENSP00000384401; ENSP00000384937; ENSP00000319984; ENSP00000384346; ENSP00000385652

Entrez Proteins:
AAA51570.1; AAH95547.1; AAI06742.1; AAI06743.1; AAK68113.1; AAM18939.1; AAO23567.1; AAO23568.1; AAO23569.1; AAO65595.1; AAO65596.1; AAO65597.1; AAR14893.1; AAR14894.1; BAA94476.1; BAF82925.1; CAA33335.1; EAL24054.1; EAW83866.1

RefSeq Proteins:
ID  Description
NP_000730  cholinergic receptor, muscarinic 2 [Homo sapiens].
NP_001006627  cholinergic receptor, muscarinic 2 [Homo sapiens].
NP_001006628  cholinergic receptor, muscarinic 2 [Homo sapiens].
NP_001006629  cholinergic receptor, muscarinic 2 [Homo sapiens].
NP_001006630  cholinergic receptor, muscarinic 2 [Homo sapiens].
NP_001006631  cholinergic receptor, muscarinic 2 [Homo sapiens].
NP_001006632  cholinergic receptor, muscarinic 2 [Homo sapiens].
NP_001006633  cholinergic receptor, muscarinic 2 [Homo sapiens].

UniProt:
ID  Description
A4D1Q0  SubName: Full=cDNA FLJ77278, highly similar to Homo sapiens cholinergic receptor, muscarinic 2 (CHRM2), transcript variant 4, mRNA; SubName: Full=Cholinergic receptor, muscarinic 2; SubName: Full=HCG1641225;
Q6SL56  SubName: Full=M2 muscarinic acetylcholine receptor; Flags: Fragment;
Q86SJ1  SubName: Full=Muscarinic M2 receptor; Flags: Fragment;
Q96RH0  SubName: Full=M2 muscarinic cholinergic receptor;
P08172  RecName: Full=Muscarinic acetylcholine receptor M2;

Domains
SMART:
- Hyperlink to SMART; - Hyperlink to ENSEMBL

InterPro:
ID  Name
IPR017452  GPCR_Rhodpsn_supfam
IPR000276  GPCR_Rhodpsn
IPR000995  Musac_rcpt
IPR001065  Musac_M2_rcpt

Pfam:
ID  Description
7tm_1  7 transmembrane receptor (rhodopsin family)

Structure
PDB:
ID
1LUB

HSSP:
ID  Description
2vt4  RECEPTOR
3eml  MEMBRANE PROTEIN, RECEPTOR

PSSH:
ID  Description
Q96RH0  UNKNOWN
A4D1Q0  UNKNOWN
P08172  UNKNOWN

Diseases
OMIM:
OMIM ID  Name  Alt Name
118493  CHOLINERGIC RECEPTOR, MUSCARINIC, 2; CHRM2   ACETYLCHOLINE RECEPTOR, MUSCARINIC, 2

Gene Ontology
GO:
GO ID  Description
GO:0001584  rhodopsin-like receptor activity
GO:0004872  receptor activity
GO:0004969  histamine receptor activity
GO:0004981  muscarinic acetylcholine receptor activity
GO:0004989  octopamine receptor activity
GO:0005624  membrane fraction
GO:0005886  plasma membrane
GO:0005887  integral to plasma membrane
GO:0006940  regulation of smooth muscle contraction
GO:0007165  signal transduction
GO:0007186  G-protein coupled receptor protein signaling pathway
GO:0007188  G-protein signaling, coupled to cAMP nucleotide second messenger
GO:0007207  activation of phospholipase C activity by muscarinic acetylcholine receptor signaling pathway
GO:0007213  muscarinic acetylcholine receptor signaling pathway
GO:0007399  nervous system development
GO:0008016  regulation of heart contraction
GO:0016020  membrane
GO:0016021  integral to membrane
GO:0030054  cell junction
GO:0045202  synapse
GO:0045211  postsynaptic membrane

Pathway
KEGG:
KEGG PATHWAY ID  Name
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04810  Regulation of actin cytoskeleton

Panther:
ID  Description
P00003  Alzheimer disease-amyloid secretase pathway
P00026  Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
P00043  Muscarinic acetylcholine receptor 2 and 4 signaling pathway
P00027  Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway

Chemicals
DrugBank:
ID  Name  Synonyms
DB01085  Pilocarpine  Adsorbocarpine; Beta-pilocarpine hydrochloride; Pilocarpin; Pilocarpine HCl; Pilocarpine chloride; Pilocarpine hydrochloride; Pilocarpine monohydrochloride; Pilocarpine muriate; Pilokarpin; Pilokarpin monohydrochloride; Spersacarpine; Spersacarpine hydrochloride
DB01069  Promethazine  Isopromethazine; Lilly 1516; Proazaimine; Proazamine; Promazinamide; Promethazin; Promethazine Hcl; Promethiazine; Promezathine; Prothazin; Prothazine
DB01135  Doxacurium chloride  
DB01334  Doxacurium  
DB00420  Promazine  CPZ; Chlorpromazine Hcl; Phenothiazine; Promazin; Promazina; Promazine Hcl
DB00572  Atropine  Atropin [German]; Atropina [Italian]; Atropine Sulfate; DL-Hyoscyamine; DL-Tropyl tropate
DB00785  Cryptenamine  
DB01403  Methotrimeprazine  Levomepromazine
DB00332  Ipratropium  Ipatropium Bromide; Ipratropium Bromide; N-Isopropylatropine; ipratropium
DB01176  Cyclizine  Ciclizina [INN-Spanish]; Cyclizine Chloride; Cyclizine Hydrochloride; Cyclizinum [INN-Latin]
DB01336  Metocurine  
DB00340  Metixene  Methixen [German]; Methixene; Methixene hydrochloride; Metisene [DCIT]; Metixene hydrochloride; Metixeno [INN-Spanish]; Metixenum [INN-Latin]
DB01062  Oxybutynin  Oxibutinina [INN-Spanish]; Oxibutyninum; Oxybutinin; Oxybutynin Base; Oxybutynin Chloride; Oxybutynin Hydrochloride; Oxybutynine [INN-French]; Oxybutyninum [INN-Latin]; oxybutynin; oxybutynin topical gel; transdermal patch
DB01151  Desipramine  DMI; Demethylimipramine; Desimipramine; Desimpramine; Desipramin; Desipramine Hcl; Desmethylimipramine; Dezipramine; Dimethylimipramine; Methylaminopropyliminodibenzyl; Monodemethylimipramine; Norimipramine; Norpramine
DB01036  Tolterodine  Tolterodina [INN-Spanish]; Tolterodine L-Tartrate; Tolterodine Tartrate; Tolterodine [INN]; Tolterodinum [INN-Latin]; Tolterondine Tartrate; tolterodine extended release capsules
DB00372  Thiethylperazine  Ethylthioperazine; Theithylperazine
DB00508  Triflupromazine  
DB00424  Hyoscyamine  Hyocyamine; L-Atropine; L-Hyopscyamine; L-Hyoscamine; L-Hyoscyamine; L-Tropine Tropate
DB00767  Benzquinamide  
DB00517  Anisotropine Methylbromide  
DB00383  Oxyphencyclimine  Oxifencicliminum [INN-Spanish]; Oxiphencycliminum; Oxyphencyclimine Hydrochloride; Oxyphencycliminum [INN-Latin]
DB01148  Flavoxate  Flavoxate HCI; Flavoxate HCL
DB01231  Diphenidol  Difenidol; Difenidol HCl; Difenidol hydrochloride; Difenidolo [DCIT]; Difenidolum [INN-Latin]; Diphenidol HCl; Diphenidol hydrochloride
DB00334  Olanzapine  olanzapine
DB00411  Carbachol  
DB00777  Propiomazine  
DB00505  Tridihexethyl  
DB01226  Mivacurium  
DB00728  Rocuronium  
DB00725  Homatropine Methylbromide  
DB00387  Procyclidine  Prociclidina [INN-Spanish]; Procyclidinum [INN-Latin]
DB00483  Gallamine Triethiodide  Benzcurine Iodide; Benzkurin; Gallamin; Gallamin Triethiodide; Gallamine; Gallamine Iodide; Gallamine Triethiiodide; Gallamine Triiodoethylate; Gallamone Triethiodide; Gallamonum; Triiodoethylate de Gallamine
HMDB:
ID  Name  Synonyms
Other GPCR resources
Links to other GPCR resources
GPCRDB | GPCR-OKB | GLIDA
Orthology
Orthology Relations:
Gene Gene Description Organism Orthology type Orthologs Orthologs Description
ENSG00000181072 Muscarinic acetylcholine receptor M2 [Source:UniProtKB/Swiss-Prot;Acc:P08172] Pan_troglodytesone2one ENSPTRG00000019734Muscarinic acetylcholine receptor M2 (Fragment). [Source:UniProtKB/Swiss-Prot;Acc:Q9N2A7][hgnc]LOC738627
Pongo_pygmaeusone2one ENSPPYG00000018033Muscarinic acetylcholine receptor m2 (Fragment). [Source:UniProtKB/TrEMBL;Acc:Q9N2A5][hgnc]
Tarsius_syrichtaone2one ENSTSYG00000011854Muscarinic acetylcholine receptor M2 [Source:UniProtKB/Swiss-Prot;Acc:P08172][hgnc]
Vicugna_pacosone2one ENSVPAG00000009472Muscarinic acetylcholine receptor M2 [Source:UniProtKB/Swiss-Prot;Acc:P08172][hgnc]
Tursiops_truncatusone2one ENSTTRG00000008660Muscarinic acetylcholine receptor M2 [Source:UniProtKB/Swiss-Prot;Acc:P08172][hgnc]
Cavia_porcellusone2one ENSCPOG00000014714Muscarinic receptor 2 (Fragment). [Source:UniProtKB/TrEMBL;Acc:Q8VH27][hgnc]
Otolemur_garnettiione2one ENSOGAG00000009009Muscarinic acetylcholine receptor M2 [Source:UniProtKB/Swiss-Prot;Acc:P08172][hgnc]
Canis_familiarisone2one ENSCAFG00000003363Muscarinic acetylcholine receptor m2 (Fragment). [Source:UniProtKB/TrEMBL;Acc:O77694][hgnc]CHRM2
Ochotona_princepsone2one ENSOPRG00000007555Muscarinic acetylcholine receptor M2 [Source:UniProtKB/Swiss-Prot;Acc:P08172][hgnc]
Myotis_lucifugusone2one ENSMLUG00000017487Muscarinic acetylcholine receptor M2 [Source:UniProtKB/Swiss-Prot;Acc:P08172][hgnc]
Oryctolagus_cuniculusone2one ENSOCUG00000016569Muscarinic acetylcholine receptor M2 [Source:UniProtKB/Swiss-Prot;Acc:P08172][hgnc]
Equus_caballusone2one ENSECAG00000024370Muscarinic acetylcholine receptor M2 [Source:UniProtKB/Swiss-Prot;Acc:P08172][hgnc]
Bos_taurusone2one ENSBTAG00000014674Muscarinic acetylcholine receptor M2. [Source:UniProtKB/Swiss-Prot;Acc:P41985][hgnc]CHRM2
Echinops_telfairione2one ENSETEG00000014210Muscarinic acetylcholine receptor M2 [Source:UniProtKB/Swiss-Prot;Acc:P08172][hgnc]
Mus_musculusone2one ENSMUSG00000045613Muscarinic acetylcholine receptor M2 [Source:UniProtKB/Swiss-Prot;Acc:Q9ERZ4][hgnc]Chrm2
Rattus_norvegicusone2one ENSRNOG00000011928Muscarinic acetylcholine receptor M2. [Source:UniProtKB/Swiss-Prot;Acc:P10980][hgnc]Chrm2
Dipodomys_ordiione2one ENSDORG00000006528Muscarinic acetylcholine receptor M2 [Source:UniProtKB/Swiss-Prot;Acc:Q9ERZ4][hgnc]
Monodelphis_domesticaone2one ENSMODG00000024440Muscarinic acetylcholine receptor M2 [Source:UniProtKB/Swiss-Prot;Acc:P08172][hgnc]
Ornithorhynchus_anatinusone2one ENSOANG00000005015Muscarinic acetylcholine receptor M2 [Source:UniProtKB/Swiss-Prot;Acc:P08172][hgnc]100075952
Gallus_gallusone2one ENSGALG00000012894Muscarinic acetylcholine receptor M2. [Source:UniProtKB/Swiss-Prot;Acc:P30372][hgnc]CHRM2
Xenopus_tropicalisone2one ENSXETG00000020175Muscarinic acetylcholine receptor M2 [Source:UniProtKB/Swiss-Prot;Acc:P08172][hgnc]
Takifugu_rubripesone2many ENSTRUG00000015946Muscarinic acetylcholine receptor M2 [Source:UniProtKB/Swiss-Prot;Acc:P08172][hgnc]
Danio_rerioone2many ENSDARG00000055577cholinergic receptor, muscarinic 2 [Source:RefSeq_peptide;Acc:NP_840086][hgnc]LOC794683
Oryzias_latipesone2many ENSORLG00000016091Muscarinic acetylcholine receptor M2 [Source:UniProtKB/Swiss-Prot;Acc:P08172][hgnc]
Gasterosteus_aculeatusone2many ENSGACG00000019948Muscarinic acetylcholine receptor M2 [Source:UniProtKB/Swiss-Prot;Acc:P08172][hgnc]
Tetraodon_nigroviridisone2many ENSTNIG00000011397Muscarinic acetylcholine receptor M2 [Source:UniProtKB/Swiss-Prot;Acc:P08172][hgnc]
Takifugu_rubripesone2many ENSTRUG00000010086Muscarinic acetylcholine receptor M2 [Source:UniProtKB/Swiss-Prot;Acc:P08172][hgnc]
Danio_rerioone2many ENSDARG00000029994[hgnc]LOC555516
Gasterosteus_aculeatusone2many ENSGACG00000011914Muscarinic acetylcholine receptor M2 [Source:UniProtKB/Swiss-Prot;Acc:P08172][hgnc]
Oryzias_latipesone2many ENSORLG00000010778Muscarinic acetylcholine receptor M2 [Source:UniProtKB/Swiss-Prot;Acc:P08172][hgnc]
Tetraodon_nigroviridisone2many ENSTNIG00000012130Muscarinic acetylcholine receptor M2 [Source:UniProtKB/Swiss-Prot;Acc:P08172][hgnc]