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Summary sheet information for GPCR 'ADRENERGIC RECEPTORS_A2C_Homo sapiens'
Name ADRENERGIC RECEPTORS_A2C_Homo sapiens
Description RecName: Full=Alpha-2C adrenergic receptor;AltName: Full=Alpha-2C adrenoreceptor;AltName: Full=Alpha-2C adrenoceptor;AltName: Full=Alpha-2 adrenergic receptor subtype C4
Class CLASS A
Family ADRENERGIC RECEPTORS
Sub_family A2C
type
Protein features link Protein Information from Dasty2 DAS Client
GPCR, G-protein, Effector interaction Visualizaton of GPCR, G-protein, Effector interaction at protein level
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Genes
Gene Location:
Chromosome: 4
Gene Start: 3738094
Gene End: 3740051
Ensembl Contig View

Ensembl Genes:
ENSG00000184160

EMBL:
EMBL ID  Description
AC141928  Homo sapiens fosmid clone XXFOS-85085A9 from 4, complete sequence.
AF280399  Homo sapiens alpha 2C adrenergic receptor (ADRA2C) gene, complete cds.
AF280400  Homo sapiens alpha 2C adrenergic receptor variant (ADRA2C) gene, complete cds.
AY455666  Homo sapiens adrenergic receptor alpha 2C (ADRA2C) gene, complete cds.
AY605898  Homo sapiens haplotype 1 alpha2C adrenergic receptor (ADRA2C) gene, complete cds.
BC142625  Homo sapiens adrenergic, alpha-2C-, receptor, mRNA (cDNA clone MGC:164798 IMAGE:40147492), complete cds.
D13538  Homo sapiens alpha2CII-adrenergic receptor gene, complete cds.
EU332833  Homo sapiens adrenergic, alpha-2C-, receptor (ADRA2C) gene, complete cds.
J03853  Human kidney alpha-2-adrenergic receptor mRNA, complete cds.
U72648  Homo sapiens alpha2-C4-adrenergic receptor gene, complete cds.
X59684  H.sapiens DNA for alpha2-1.8 adrenergic receptor gene

EntrezGene:
ID  Description
ADRA2C  adrenergic, alpha-2C-, receptor

RefSeq DNA:
ID  Description
NM_000683  Homo sapiens adrenergic, alpha-2C-, receptor (ADRA2C), mRNA.

UniGene:
ID  Description
Hs.123022  Kidney alpha-2-adrenergic receptor

Proteins
Ensembl Proteins:
ENSP00000386069

Entrez Proteins:
AAA35513.1; AAC78723.1; AAG28076.1; AAG28077.1; AAI42626.1; AAR18071.1; AAT02221.1; AAY41059.1; ABY87522.1; BAA02737.1

RefSeq Proteins:
ID  Description
NP_000674  alpha-2C-adrenergic receptor [Homo sapiens].

UniProt:
ID  Description
Q4W594  SubName: Full=Putative uncharacterized protein ADRA2C (Adrenergic, alpha-2C-, receptor);
P18825  RecName: Full=Alpha-2C adrenergic receptor; AltName: Full=Alpha-2C adrenoreceptor; AltName: Full=Alpha-2C adrenoceptor; AltName: Full=Alpha-2 adrenergic receptor subtype C4;

Domains
SMART:
- Hyperlink to SMART; - Hyperlink to ENSEMBL

InterPro:
ID  Name
IPR000735  Adren_rcpt_A2C
IPR000276  GPCR_Rhodpsn
IPR015695  Adren_rcpt_A2A/B/C
IPR002233  Adrnrgc_rcpt
IPR017452  GPCR_Rhodpsn_supfam

Pfam:
ID  Description
7tm_1  7 transmembrane receptor (rhodopsin family)

Structure
PDB:
ID

HSSP:
ID  Description
1hll  MEMBRANE PROTEIN
1ho9  MEMBRANE PROTEIN
1hod  MEMBRANE PROTEIN
1hof  MEMBRANE PROTEIN
2vt4  RECEPTOR

PSSH:
ID  Description
Q4W594  UNKNOWN
P18825  UNKNOWN

Diseases
OMIM:
OMIM ID  Name  Alt Name
104250  ALPHA-2C-ADRENERGIC RECEPTOR; ADRA2C   ALPHA-2-ADRENERGIC RECEPTOR, RENAL TYPE

Gene Ontology
GO:
GO ID  Description
GO:0000187  activation of MAPK activity
GO:0001584  rhodopsin-like receptor activity
GO:0003677  DNA binding
GO:0004872  receptor activity
GO:0004879  ligand-dependent nuclear receptor activity
GO:0004930  G-protein coupled receptor activity
GO:0004935  adrenoceptor activity
GO:0004938  alpha2-adrenergic receptor activity
GO:0004952  dopamine receptor activity
GO:0004977  melanocortin receptor activity
GO:0004981  muscarinic acetylcholine receptor activity
GO:0004989  octopamine receptor activity
GO:0005515  protein binding
GO:0005634  nucleus
GO:0005768  endosome
GO:0005886  plasma membrane
GO:0005887  integral to plasma membrane
GO:0006355  regulation of transcription, DNA-dependent
GO:0007165  signal transduction
GO:0007186  G-protein coupled receptor protein signaling pathway
GO:0007267  cell-cell signaling
GO:0016020  membrane
GO:0016021  integral to membrane

Pathway
KEGG:
KEGG PATHWAY ID  Name
hsa04080  Neuroactive ligand-receptor interaction

Panther:
ID  Description
P00026  Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway

Chemicals
DrugBank:
ID  Name  Synonyms
DB01170  Guanethidine  Guanethidine Monosulfate; Guanethidine Sulphae
DB01392  Yohimbine  Yohimbin
DB00217  Bethanidine  Betanidin; Betanidine; Bethanidine sulfate
DB00226  Guanadrel Sulfate  Guanadrelum [INN-Latin]
DB00368  Norepinephrine  Arterenol; L-Norepinephrine; L-noradrenaline; Noradrenaline; Norepinephrine
DB04840  Debrisoquin  Debrisochinum; Debrisoquin hemisulfate; Debrisoquin sulfate; Debrisoquina [inn-spanish]; Debrisoquine; Debrisoquine sulfate; Debrisoquinum [inn-latin]; Isocaramidine; Isocaramidine sulfate
DB04948  Lofexidine  2-(1-(2,6-Dichlorophenoxy)ethyl)-4,5-dihydro-1H-imidazole; 2-(alpha-(2,6-Dichlorophenoxy)ethyl)2-imidazoline; Lofexidina [inn-spanish]; Lofexidine hydrochloride; Lofexidinum [inn-latin]; lofexidine
DB00800  Fenoldopam  Fenodopam mesylate; Fenoldopam mesylate; Fenoldopamum [Latin]
DB06262  Droxidopa  Droxydopa; L-DOPS; L-dihydroxyphenylserine; L-threo-3,4-dihydroxyphenylserine
DB00484  Brimonidine  Brimonidine tartrate; Bromoxidine
HMDB:
ID  Name  Synonyms
Other GPCR resources
Links to other GPCR resources
GPCRDB | GPCR-OKB | GLIDA
Orthology
Orthology Relations:
Gene Gene Description Organism Orthology type Orthologs Orthologs Description
ENSG00000184160 Alpha-2C adrenergic receptor (Alpha-2C adrenoreceptor) (Alpha-2C adrenoceptor) (Alpha-2 adrenergic receptor subtype C4) [Source:UniProtKB/Swiss-Prot;Acc:P18825] Pan_troglodytesone2one ENSPTRG00000034025PREDICTED: Pan troglodytes similar to alpha 2C adrenergic receptor (LOC465178), mRNA. [Source:RefSeq_dna;Acc:XR_025329][hgnc]LOC465178
Canis_familiarisone2one ENSCAFG00000014602Alpha-2C adrenergic receptor (Alpha-2C adrenoreceptor) (Alpha-2C adrenoceptor) (Alpha-2 adrenergic receptor subtype C4) [Source:UniProtKB/Swiss-Prot;Acc:P18825][hgnc]
Rattus_norvegicusone2one ENSRNOG00000009299Alpha-2C adrenergic receptor (Alpha-2C adrenoceptor) (Alpha-2C adrenoreceptor) (Alpha-2 adrenergic receptor subtype C4). [Source:UniProtKB/Swiss-Prot;Acc:P22086][hgnc]Adra2c
Mus_musculusone2one ENSMUSG00000045318Alpha-2C adrenergic receptor (Alpha-2C adrenoreceptor) (Alpha-2C adrenoceptor) (Alpha-2 adrenergic receptor subtype C4) [Source:UniProtKB/Swiss-Prot;Acc:Q01337][hgnc]LOC100045767
Macaca_mulattaone2one ENSMMUG00000014781Alpha-2C adrenergic receptor (Alpha-2C adrenoreceptor) (Alpha-2C adrenoceptor) (Alpha-2 adrenergic receptor subtype C4) [Source:UniProtKB/Swiss-Prot;Acc:P18825][hgnc]
Monodelphis_domesticaone2one ENSMODG00000003290Alpha-2C adrenergic receptor (Alpha-2C adrenoreceptor) (Alpha-2C adrenoceptor) (Alpha-2 adrenergic receptor subtype C4) [Source:UniProtKB/Swiss-Prot;Acc:P18825][hgnc]
Gallus_gallusone2one ENSGALG00000015608Alpha-2C adrenergic receptor (Alpha-2C adrenoreceptor) (Alpha-2C adrenoceptor) (Alpha-2 adrenergic receptor subtype C4) [Source:UniProtKB/Swiss-Prot;Acc:P18825][hgnc]ADRA2C
Xenopus_tropicalisone2one ENSXETG00000015427Alpha-2C adrenergic receptor (Alpha-2C adrenoreceptor) (Alpha-2C adrenoceptor) (Alpha-2 adrenergic receptor subtype C4) [Source:UniProtKB/Swiss-Prot;Acc:P18825][hgnc]
Oryzias_latipesone2many ENSORLG00000006057Alpha-2C adrenergic receptor (Alpha-2C adrenoreceptor) (Alpha-2C adrenoceptor) (Alpha-2 adrenergic receptor subtype C4) [Source:UniProtKB/Swiss-Prot;Acc:P18825][hgnc]
Gasterosteus_aculeatusone2many ENSGACG00000019417Alpha-2C adrenergic receptor (Alpha-2C adrenoreceptor) (Alpha-2C adrenoceptor) (Alpha-2 adrenergic receptor subtype C4) [Source:UniProtKB/Swiss-Prot;Acc:P18825][hgnc]
Tetraodon_nigroviridisone2many ENSTNIG00000012046Alpha-2C adrenergic receptor (Alpha-2C adrenoreceptor) (Alpha-2C adrenoceptor) (Alpha-2 adrenergic receptor subtype C4) [Source:UniProtKB/Swiss-Prot;Acc:P18825][hgnc]
Tetraodon_nigroviridisone2many ENSTNIG00000010151Alpha-2C adrenergic receptor (Alpha-2C adrenoreceptor) (Alpha-2C adrenoceptor) (Alpha-2 adrenergic receptor subtype C4) [Source:UniProtKB/Swiss-Prot;Acc:P18825][hgnc]
Gasterosteus_aculeatusone2many ENSGACG00000018364Alpha-2C adrenergic receptor (Alpha-2C adrenoreceptor) (Alpha-2C adrenoceptor) (Alpha-2 adrenergic receptor subtype C4) [Source:UniProtKB/Swiss-Prot;Acc:P18825][hgnc]
Takifugu_rubripesone2many ENSTRUG00000003591Alpha2 c1 adrenergic receptor. [Source:UniProtKB/TrEMBL;Acc:Q8JG06][hgnc]
Takifugu_rubripesone2many ENSTRUG00000010714Alpha-2C adrenergic receptor (Alpha-2C adrenoreceptor) (Alpha-2C adrenoceptor) (Alpha-2 adrenergic receptor subtype C4) [Source:UniProtKB/Swiss-Prot;Acc:P18825][hgnc]
Oryzias_latipesone2many ENSORLG00000014425Alpha-2C adrenergic receptor (Alpha-2C adrenoreceptor) (Alpha-2C adrenoceptor) (Alpha-2 adrenergic receptor subtype C4) [Source:UniProtKB/Swiss-Prot;Acc:P18825][hgnc]
Equus_caballusapprent_one2one ENSECAG00000006948Alpha-2B adrenergic receptor (Alpha-2B adrenoceptor) (Alpha-2B adrenoreceptor) (Fragment). [Source:UniProtKB/Swiss-Prot;Acc:O77721][hgnc]LOC100051684
Pongo_pygmaeusapprent_one2one ENSPPYG00000012061Alpha-2C adrenergic receptor (Alpha-2C adrenoreceptor) (Alpha-2C adrenoceptor) (Alpha-2 adrenergic receptor subtype C4) [Source:UniProtKB/Swiss-Prot;Acc:P18825][hgnc]
Bos_taurusapprent_one2one ENSBTAG00000009510Alpha-2B adrenergic receptor (Alpha-2B adrenoceptor) (Alpha-2B adrenoreceptor) (Fragment). [Source:UniProtKB/Swiss-Prot;Acc:O77700][hgnc]ADRA2B
Cavia_porcellusapprent_one2one ENSCPOG00000013367Alpha-2B adrenergic receptor (Alpha-2B adrenoreceptor) (Alpha-2B adrenoceptor). [Source:UniProtKB/Swiss-Prot;Acc:Q60475][hgnc]