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Summary sheet information for Effector 'ATP-sensitive inward rectifier potassium channel 12-Homo sapiens'
Name ATP-sensitive inward rectifier potassium channel 12-Homo sapiens
Description "RecName: Full=ATP-sensitive inward rectifier potassium channel 12;AltName: Full=Potassium channel, inwardly rectifying subfamily J member 12;AltName: Full=Inward rectifier K(+) channel Kir2.2;AltName: Full=Kir2.2v;AltName: Full=IRK2;"
Class
Family Ion channels
Sub_family ATP-sensitive inward rectifier potassium channels
type ATP-sensitive inward rectifier potassium channel 12
Protein features link Protein Information from Dasty2 DAS Client
GPCR, G-protein, Effector interaction Visualizaton of GPCR, G-protein, Effector interaction at protein level
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Genes
Gene Location:
Chromosome: 17
Gene Start: 21220292
Gene End: 21263772
Ensembl Contig View

Ensembl Genes:
ENSG00000184185

EMBL:
EMBL ID  Description
AB074970  Homo sapiens KCNJ12 gene for inward rectifier potassium channel Kir2.2, complete cds.
AB181299  Homo sapiens kcnj12x gene for hkir2.2x, complete cds.
AB182123  Homo sapiens KCNJ12 mRNA for potassium inwardly-rectifying channel kir2.2, subfamily J, member 12, complete cds.
AF005214  Homo sapiens inward rectifying K+ channel negative regulator mRNA, complete cds.
BC027982  Homo sapiens potassium inwardly-rectifying channel, subfamily J, member 12, mRNA (cDNA clone MGC:40138 IMAGE:3873918), complete cds.
L36069  Human high conductance inward rectifier potassium channel alpha subunit mRNA, complete cds.
U53143  Human inward rectifying K+ channel negative regulator Kir2.2v gene, complete cds.

EntrezGene:
ID  Description
KCNJ12  potassium inwardly-rectifying channel, subfamily J, member 12
LOC100131509  similar to inward rectifying K+ channel negative regulator Kir2.2v
LOC100134444  similar to hkir2.2x

RefSeq DNA:
ID  Description
NM_021012  Homo sapiens potassium inwardly-rectifying channel, subfamily J, member 12 (KCNJ12), mRNA.
XM_001718636  PREDICTED: Homo sapiens similar to inward rectifying K+ channel negative regulator Kir2.2v (LOC100131509), mRNA.
XM_001720057  PREDICTED: Homo sapiens similar to hkir2.2x (LOC100134444), mRNA.

UniGene:
ID  Description
Hs.200629  Inward rectifying K+ channel negative regulator

Proteins
Ensembl Proteins:
ENSP00000328150

Entrez Proteins:
AAA65122.1; AAC01951.1; AAC50615.1; AAH27982.1; BAC02718.1; BAD22701.1; BAD23901.1

RefSeq Proteins:
ID  Description
NP_066292  potassium inwardly-rectifying channel, subfamily J, member 12 [Homo sapiens].
XP_001718688  PREDICTED: similar to inward rectifying K+ channel negative regulator Kir2.2v [Homo sapiens].
XP_001720109  PREDICTED: similar to hkir2.2x [Homo sapiens].

UniProt:
ID  Description
Q6L5N3  SubName: Full=Hkir2.2x;
Q14500  RecName: Full=ATP-sensitive inward rectifier potassium channel 12; AltName: Full=Potassium channel, inwardly rectifying subfamily J member 12; AltName: Full=Inward rectifier K(+) channel Kir2.2; AltName: Full=Kir2.2v; AltName: Full=IRK2;

Domains
SMART:
- Hyperlink to SMART; - Hyperlink to ENSEMBL
     ATP-sensitive inward rectifier potassium channel 12-Homo sapiens    

InterPro:
ID  Name
IPR003272  K_chnl_inward-rec_Kir2.2
IPR013518  K_chnl_inward-rec_Kir_cyto
IPR001838  K_chnl_inward-rec_Kir-like
IPR013673  K_chnl_inward-rec_Kir_N
IPR013521  K_chnl_inward-rec_Kir_Cr2
IPR016449  K_chnl_inward-rec_Kir

Pfam:
ID  Description
IRK  Inward rectifier potassium channel
IRK_N  Inward rectifier potassium channel N-terminal

Structure
PDB:
ID

HSSP:
ID  Description
1n9p  METAL TRANSPORT
1p7b  METAL TRANSPORT
1u4e  METAL TRANSPORT
1u4f  ALLERGEN
2e4f  TRANSPORT PROTEIN
2gix  METAL TRANSPORT
2qks  METAL TRANSPORT

PSSH:
ID  Description
Q6L5N3  UNKNOWN
Q14500  UNKNOWN

Diseases
OMIM:
OMIM ID  Name  Alt Name
602323  POTASSIUM CHANNEL, INWARDLY RECTIFYING, SUBFAMILY J, MEMBER 12; KCNJ12   POTASSIUM CHANNEL, INWARDLY RECTIFYING, SUBFAMILY J, INHIBITOR 1; KCNJN1 INWARDLY RECTIFYING POTASSIUM CHANNEL Kir2.2

Gene Ontology
GO:
GO ID  Description
GO:0005242  inward rectifier potassium channel activity
GO:0005244  voltage-gated ion channel activity
GO:0005515  protein binding
GO:0006811  ion transport
GO:0006813  potassium ion transport
GO:0006936  muscle contraction
GO:0008015  blood circulation
GO:0008016  regulation of heart contraction
GO:0008200  ion channel inhibitor activity
GO:0015459  potassium channel regulator activity
GO:0015467  G-protein activated inward rectifier potassium channel activity
GO:0016020  membrane
GO:0016021  integral to membrane
GO:0030165  PDZ domain binding
GO:0030315  T-tubule
GO:0030425  dendrite
GO:0030955  potassium ion binding
GO:0043025  cell soma

Pathway
KEGG:
KEGG PATHWAY ID  Name

Panther:
ID  Description

Chemicals
DrugBank:
ID  Name  Synonyms
DB00204  Dofetilide  Dofetilida [INN-Spanish]; Dofetilidum [INN-Latin]
HMDB:
ID  Name  Synonyms
Orthology
Orthology Relations:
Gene Gene Description Organism Orthology type Orthologs Orthologs Description
ENSG00000184185 ATP-sensitive inward rectifier potassium channel 12 (Potassium channel, inwardly rectifying subfamily J member 12) (Inward rectifier K(+) channel Kir2.2) (Kir2.2v) (IRK2) [Source:UniProtKB/Swiss-Prot;Acc:Q14500] Xenopus_tropicalisone2one ENSXETG00000007492ATP-sensitive inward rectifier potassium channel 12 (Potassium channel, inwardly rectifying subfamily J member 12) (Inward rectifier K(+) channel Kir2.2) (Kir2.2v) (IRK2) [Source:UniProtKB/Swiss-Prot;Acc:Q14500][hgnc]
Gasterosteus_aculeatusone2one ENSGACG00000008541ATP-sensitive inward rectifier potassium channel 12 (Potassium channel, inwardly rectifying subfamily J member 12) (Inward rectifier K(+) channel Kir2.2) (Kir2.2v) (IRK2) [Source:UniProtKB/Swiss-Prot;Acc:Q14500][hgnc]
Aedes_aegyptimany2many AAEL008931inwardly rectifying k+ channel,[hgnc]
Caenorhabditis_elegansmany2many R03E9.4Inward rectifier potassium channel irk-1. [Source:UniProtKB/Swiss-Prot;Acc:P52192][hgnc]irk-1
Aedes_aegyptimany2many AAEL013373inwardly rectifying k+ channel,[hgnc]
Pan_troglodytesone2one ENSPTRG00000031376PREDICTED: Pan troglodytes potassium inwardly-rectifying channel J12 (KCNJ12), mRNA. [Source:RefSeq_dna;Acc:XR_025561][hgnc]KCNJ12
Macaca_mulattaone2one ENSMMUG00000010903ATP-sensitive inward rectifier potassium channel 12 (Potassium channel, inwardly rectifying subfamily J member 12) (Inward rectifier K(+) channel Kir2.2) (Kir2.2v) (IRK2) [Source:UniProtKB/Swiss-Prot;Acc:Q14500][hgnc]
Pongo_pygmaeusone2one ENSPPYG00000008074ATP-sensitive inward rectifier potassium channel 12 (Potassium channel, inwardly rectifying subfamily J member 12) (Inward rectifier K(+) channel Kir2.2) (Kir2.2v) (IRK2) [Source:UniProtKB/Swiss-Prot;Acc:Q14500][hgnc]
Tarsius_syrichtaone2one ENSTSYG00000002697ATP-sensitive inward rectifier potassium channel 12 (Potassium channel, inwardly rectifying subfamily J member 12) (Inward rectifier K(+) channel Kir2.2) (Kir2.2v) (IRK2) [Source:UniProtKB/Swiss-Prot;Acc:Q14500][hgnc]
Felis_catusone2one ENSFCAG00000008822ATP-sensitive inward rectifier potassium channel 12 (Potassium channel, inwardly rectifying subfamily J member 12) (Inward rectifier K(+) channel Kir2.2) (Kir2.2v) (IRK2) [Source:UniProtKB/Swiss-Prot;Acc:Q14500][hgnc]
Tursiops_truncatusone2one ENSTTRG00000005387ATP-sensitive inward rectifier potassium channel 12 (Potassium channel, inwardly rectifying subfamily J member 12) (Inward rectifier K(+) channel Kir2.2) (Kir2.2v) (IRK2) [Source:UniProtKB/Swiss-Prot;Acc:Q14500][hgnc]
Canis_familiarisone2one ENSCAFG00000018532Atrium potassium channel IRK (Fragment). [Source:UniProtKB/TrEMBL;Acc:O62726][hgnc]KCNJ12
Cavia_porcellusone2one ENSCPOG00000013146Inward rectifier potassium channel Kir2.2. [Source:UniProtKB/TrEMBL;Acc:Q99PR2][hgnc]
Dipodomys_ordiione2one ENSDORG00000004888ATP-sensitive inward rectifier potassium channel 12 (Potassium channel, inwardly rectifying subfamily J member 12) (Inward rectifier K(+) channel Kir2.2) (IRK2) [Source:UniProtKB/Swiss-Prot;Acc:P52187][hgnc]
Equus_caballusone2one ENSECAG00000003664ATP-sensitive inward rectifier potassium channel 12 (Potassium channel, inwardly rectifying subfamily J member 12) (Inward rectifier K(+) channel Kir2.2) (Kir2.2v) (IRK2) [Source:UniProtKB/Swiss-Prot;Acc:Q14500][hgnc]LOC100053570
Sorex_araneusone2one ENSSARG00000003197ATP-sensitive inward rectifier potassium channel 12 (Potassium channel, inwardly rectifying subfamily J member 12) (Inward rectifier K(+) channel Kir2.2) (Kir2.2v) (IRK2) [Source:UniProtKB/Swiss-Prot;Acc:Q14500][hgnc]
Erinaceus_europaeusone2one ENSEEUG00000006365ATP-sensitive inward rectifier potassium channel 12 (Potassium channel, inwardly rectifying subfamily J member 12) (Inward rectifier K(+) channel Kir2.2) (Kir2.2v) (IRK2) [Source:UniProtKB/Swiss-Prot;Acc:Q14500][hgnc]
Otolemur_garnettiione2one ENSOGAG00000000051ATP-sensitive inward rectifier potassium channel 12 (Potassium channel, inwardly rectifying subfamily J member 12) (Inward rectifier K(+) channel Kir2.2) (Kir2.2v) (IRK2) [Source:UniProtKB/Swiss-Prot;Acc:Q14500][hgnc]
Loxodonta_africanaone2one ENSLAFG00000009895ATP-sensitive inward rectifier potassium channel 12 (Potassium channel, inwardly rectifying subfamily J member 12) (Inward rectifier K(+) channel Kir2.2) (Kir2.2v) (IRK2) [Source:UniProtKB/Swiss-Prot;Acc:Q14500][hgnc]
Pteropus_vampyrusone2one ENSPVAG00000011160ATP-sensitive inward rectifier potassium channel 12 (Potassium channel, inwardly rectifying subfamily J member 12) (Inward rectifier K(+) channel Kir2.2) (Kir2.2v) (IRK2) [Source:UniProtKB/Swiss-Prot;Acc:Q14500][hgnc]
Mus_musculusone2one ENSMUSG00000042529ATP-sensitive inward rectifier potassium channel 12 (Potassium channel, inwardly rectifying subfamily J member 12) (Inward rectifier K(+) channel Kir2.2) (IRK2) [Source:UniProtKB/Swiss-Prot;Acc:P52187][hgnc]Kcnj12
Rattus_norvegicusone2one ENSRNOG00000002303ATP-sensitive inward rectifier potassium channel 12 (Potassium channel, inwardly rectifying subfamily J member 12) (Inward rectifier K(+) channel Kir2.2) (IRK2). [Source:UniProtKB/Swiss-Prot;Acc:P52188][hgnc]Kcnj12
Monodelphis_domesticaone2one ENSMODG00000001377ATP-sensitive inward rectifier potassium channel 12 (Potassium channel, inwardly rectifying subfamily J member 12) (Inward rectifier K(+) channel Kir2.2) (Kir2.2v) (IRK2) [Source:UniProtKB/Swiss-Prot;Acc:Q14500][hgnc]
Ornithorhynchus_anatinusone2one ENSOANG00000007731ATP-sensitive inward rectifier potassium channel 12 (Potassium channel, inwardly rectifying subfamily J member 12) (Inward rectifier K(+) channel Kir2.2) (Kir2.2v) (IRK2) [Source:UniProtKB/Swiss-Prot;Acc:Q14500][hgnc]100081081
Gallus_gallusone2one ENSGALG00000004721ATP-sensitive inward rectifier potassium channel 12 (Potassium channel, inwardly rectifying subfamily J member 12) (Inward rectifier K(+) channel Kir2.2) (Kir2.2v) (IRK2) [Source:UniProtKB/Swiss-Prot;Acc:Q14500][hgnc]KCNJ12
Tetraodon_nigroviridisone2one ENSTNIG00000012845ATP-sensitive inward rectifier potassium channel 12 (Potassium channel, inwardly rectifying subfamily J member 12) (Inward rectifier K(+) channel Kir2.2) (Kir2.2v) (IRK2) [Source:UniProtKB/Swiss-Prot;Acc:Q14500][hgnc]
Danio_rerioone2one ENSDARG00000059822[hgnc]LOC569146
Takifugu_rubripesone2one ENSTRUG00000016379ATP-sensitive inward rectifier potassium channel 12 (Potassium channel, inwardly rectifying subfamily J member 12) (Inward rectifier K(+) channel Kir2.2) (Kir2.2v) (IRK2) [Source:UniProtKB/Swiss-Prot;Acc:Q14500][hgnc]
Oryzias_latipesone2one ENSORLG00000008168ATP-sensitive inward rectifier potassium channel 12 (Potassium channel, inwardly rectifying subfamily J member 12) (Inward rectifier K(+) channel Kir2.2) (Kir2.2v) (IRK2) [Source:UniProtKB/Swiss-Prot;Acc:Q14500][hgnc]
Aedes_aegyptimany2many AAEL008932inwardly rectifying k+ channel,[hgnc]
Drosophila_melanogastermany2many FBgn0039061[hgnc]Ir
Anopheles_gambiaemany2many AGAP001280[hgnc]AgaP_ENSANGG00000017854
Drosophila_melanogastermany2many FBgn0039081[hgnc]Irk2
Aedes_aegyptimany2many AAEL008928inwardly rectifying k+ channel,[hgnc]
Anopheles_gambiaemany2many AGAP001283[hgnc]AgaP_ENSANGG00000017795
Anopheles_gambiaemany2many AGAP001281[hgnc]AgaP_ENSANGG00000020396
Anopheles_gambiaemany2many AGAP001284[hgnc]AgaP_ENSANGG00000024811
Caenorhabditis_elegansmany2many M02A10.2irk-2 encodes an inwardly rectifying potassium channel based on sequence homology to the the human potassium channel genes KCNJ1/KCNJ2. [Source: WormBase][hgnc]irk-2