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Summary sheet information for GPCR 'MUSCARINIC ACETYLCHOLINE RECEPTORS_M5_Homo sapiens'
Name MUSCARINIC ACETYLCHOLINE RECEPTORS_M5_Homo sapiens
Description RecName: Full=Muscarinic acetylcholine receptor M5
Class CLASS A
Family MUSCARINIC ACETYLCHOLINE RECEPTORS
Sub_family M5
type
Protein features link Protein Information from Dasty2 DAS Client
GPCR, G-protein, Effector interaction Visualizaton of GPCR, G-protein, Effector interaction at protein level
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Genes
Gene Location:
Chromosome: 15
Gene Start: 32048381
Gene End: 32144587
Ensembl Contig View

Ensembl Genes:
ENSG00000184984

EMBL:
EMBL ID  Description
AB084282  Homo sapiens mACHR for muscarinic acetylcholine receptor M5, complete cds.
AF026263  Homo sapiens muscarinic receptor (CHRM5) mRNA, complete cds.
AF385591  Homo sapiens m5 muscarinic cholinergic receptor (CHRM5) mRNA, complete cds.
AF498919  Homo sapiens muscarinic acetylcholine receptor M5 (CHRM5) mRNA, complete cds.
BC041805  Homo sapiens cholinergic receptor, muscarinic 5, mRNA (cDNA clone MGC:41838 IMAGE:5298446), complete cds.
BC068528  Homo sapiens cholinergic receptor, muscarinic 5, mRNA (cDNA clone MGC:87358 IMAGE:30339053), complete cds.
M80333  Human m5 muscarinic acetylcholine receptor gene, complete cds.

EntrezGene:
ID  Description
CHRM5  cholinergic receptor, muscarinic 5

RefSeq DNA:
ID  Description
NM_012125  Homo sapiens cholinergic receptor, muscarinic 5 (CHRM5), mRNA.

UniGene:
ID  Description
Hs.584747  Muscarinic receptor (CHRM5)

Proteins
Ensembl Proteins:
ENSP00000372750; ENSP00000331108

Entrez Proteins:
AAA51569.1; AAB95158.1; AAH41805.1; AAH68528.1; AAK68116.1; AAM18942.1; BAB91222.1

RefSeq Proteins:
ID  Description
NP_036257  cholinergic receptor, muscarinic 5 [Homo sapiens].

UniProt:
ID  Description
Q6NUM3  SubName: Full=CHRM5 protein;
Q8IVW0  SubName: Full=Cholinergic receptor, muscarinic 5;
P08912  RecName: Full=Muscarinic acetylcholine receptor M5;

Domains
SMART:
- Hyperlink to SMART; - Hyperlink to ENSEMBL

InterPro:
ID  Name
IPR000276  GPCR_Rhodpsn
IPR017452  GPCR_Rhodpsn_supfam
IPR000502  Musac_M5_rcpt
IPR000995  Musac_rcpt

Pfam:
ID  Description
7tm_1  7 transmembrane receptor (rhodopsin family)

Structure
PDB:
ID

HSSP:
ID  Description
1hll  MEMBRANE PROTEIN
1hof  MEMBRANE PROTEIN
2vt4  RECEPTOR
3eml  MEMBRANE PROTEIN, RECEPTOR

PSSH:
ID  Description
Q6NUM3  UNKNOWN
Q8IVW0  UNKNOWN
P08912  UNKNOWN

Diseases
OMIM:
OMIM ID  Name  Alt Name
118496  CHOLINERGIC RECEPTOR, MUSCARINIC, 5; CHRM5   ACETYLCHOLINE RECEPTOR, MUSCARINIC, 5

Gene Ontology
GO:
GO ID  Description
GO:0001584  rhodopsin-like receptor activity
GO:0004435  phosphoinositide phospholipase C activity
GO:0004872  receptor activity
GO:0004969  histamine receptor activity
GO:0004977  melanocortin receptor activity
GO:0004981  muscarinic acetylcholine receptor activity
GO:0005886  plasma membrane
GO:0005887  integral to plasma membrane
GO:0007165  signal transduction
GO:0007186  G-protein coupled receptor protein signaling pathway
GO:0007197  inhibition of adenylate cyclase activity by muscarinic acetylcholine receptor signaling pathway
GO:0007213  muscarinic acetylcholine receptor signaling pathway
GO:0008283  cell proliferation
GO:0015872  dopamine transport
GO:0016020  membrane
GO:0016021  integral to membrane
GO:0019226  transmission of nerve impulse
GO:0030054  cell junction
GO:0045202  synapse
GO:0045211  postsynaptic membrane

Pathway
KEGG:
KEGG PATHWAY ID  Name
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04810  Regulation of actin cytoskeleton

Panther:
ID  Description
P00003  Alzheimer disease-amyloid secretase pathway
P00026  Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
P00027  Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway

Chemicals
DrugBank:
ID  Name  Synonyms
DB00420  Promazine  CPZ; Chlorpromazine Hcl; Phenothiazine; Promazin; Promazina; Promazine Hcl
DB00767  Benzquinamide  
DB00785  Cryptenamine  
DB00572  Atropine  Atropin [German]; Atropina [Italian]; Atropine Sulfate; DL-Hyoscyamine; DL-Tropyl tropate
DB00777  Propiomazine  
DB00334  Olanzapine  olanzapine
DB01069  Promethazine  Isopromethazine; Lilly 1516; Proazaimine; Proazamine; Promazinamide; Promethazin; Promethazine Hcl; Promethiazine; Promezathine; Prothazin; Prothazine
DB01403  Methotrimeprazine  Levomepromazine
DB00725  Homatropine Methylbromide  
DB00372  Thiethylperazine  Ethylthioperazine; Theithylperazine
DB00340  Metixene  Methixen [German]; Methixene; Methixene hydrochloride; Metisene [DCIT]; Metixene hydrochloride; Metixeno [INN-Spanish]; Metixenum [INN-Latin]
HMDB:
ID  Name  Synonyms
Other GPCR resources
Links to other GPCR resources
GPCRDB | GPCR-OKB | GLIDA
Orthology
Orthology Relations:
Gene Gene Description Organism Orthology type Orthologs Orthologs Description
ENSG00000184984 Muscarinic acetylcholine receptor M5 [Source:UniProtKB/Swiss-Prot;Acc:P08912] Pan_troglodytesone2one ENSPTRG00000006874Muscarinic acetylcholine receptor M5. [Source:UniProtKB/Swiss-Prot;Acc:Q5IS53][hgnc]CHRM5
Pongo_pygmaeusone2one ENSPPYG00000006307Muscarinic acetylcholine receptor 5 (Fragment). [Source:UniProtKB/TrEMBL;Acc:Q8WNM5][hgnc]
Macaca_mulattaone2one ENSMMUG00000014227Muscarinic acetylcholine receptor M5. [Source:UniProtKB/Swiss-Prot;Acc:P56490][hgnc]574330
Otolemur_garnettiione2one ENSOGAG00000001527Muscarinic acetylcholine receptor M5 [Source:UniProtKB/Swiss-Prot;Acc:P08912][hgnc]
Tarsius_syrichtaone2one ENSTSYG00000003997Muscarinic acetylcholine receptor M5 [Source:UniProtKB/Swiss-Prot;Acc:P08912][hgnc]
Equus_caballusone2one ENSECAG00000002709Muscarinic acetylcholine receptor M5 [Source:UniProtKB/Swiss-Prot;Acc:P08912][hgnc]LOC100057856
Tursiops_truncatusone2one ENSTTRG00000007233Muscarinic acetylcholine receptor M5 [Source:UniProtKB/Swiss-Prot;Acc:P08912][hgnc]
Felis_catusone2one ENSFCAG00000003063Muscarinic acetylcholine receptor M5 [Source:UniProtKB/Swiss-Prot;Acc:P08912][hgnc]
Spermophilus_tridecemlineatusone2one ENSSTOG00000001858Muscarinic acetylcholine receptor M5 [Source:UniProtKB/Swiss-Prot;Acc:P08912][hgnc]
Tupaia_belangerione2one ENSTBEG00000009206Muscarinic acetylcholine receptor M5 [Source:UniProtKB/Swiss-Prot;Acc:P08912][hgnc]
Pteropus_vampyrusone2one ENSPVAG00000003820Muscarinic acetylcholine receptor M5 [Source:UniProtKB/Swiss-Prot;Acc:P08912][hgnc]
Vicugna_pacosone2one ENSVPAG00000007167Muscarinic acetylcholine receptor M5 [Source:UniProtKB/Swiss-Prot;Acc:P08912][hgnc]
Dasypus_novemcinctusone2one ENSDNOG00000016072Muscarinic acetylcholine receptor M5 [Source:UniProtKB/Swiss-Prot;Acc:P08912][hgnc]
Canis_familiarisone2one ENSCAFG00000008002Muscarinic acetylcholine receptor M5 [Source:UniProtKB/Swiss-Prot;Acc:P08912][hgnc]CHRM5
Procavia_capensisone2one ENSPCAG00000011293Muscarinic acetylcholine receptor M5 [Source:UniProtKB/Swiss-Prot;Acc:P08912][hgnc]
Rattus_norvegicusone2one ENSRNOG00000006397Muscarinic acetylcholine receptor M5. [Source:UniProtKB/Swiss-Prot;Acc:P08911][hgnc]Chrm5
Mus_musculusone2one ENSMUSG00000074939Muscarinic acetylcholine receptor M5 [Source:UniProtKB/Swiss-Prot;Acc:Q920H4][hgnc]Chrm5
Erinaceus_europaeusone2one ENSEEUG00000011625Muscarinic acetylcholine receptor M5 [Source:UniProtKB/Swiss-Prot;Acc:P08912][hgnc]
Echinops_telfairione2one ENSETEG00000017873Muscarinic acetylcholine receptor M5 [Source:UniProtKB/Swiss-Prot;Acc:P08912][hgnc]
Cavia_porcellusone2one ENSCPOG00000003150Muscarinic receptor 5. [Source:UniProtKB/TrEMBL;Acc:Q8VH24][hgnc]
Dipodomys_ordiione2one ENSDORG00000008797Muscarinic acetylcholine receptor M5 [Source:UniProtKB/Swiss-Prot;Acc:Q920H4][hgnc]
Monodelphis_domesticaone2one ENSMODG00000024252Muscarinic acetylcholine receptor M5 [Source:UniProtKB/Swiss-Prot;Acc:P08912][hgnc]
Gallus_gallusone2one ENSGALG00000009640cholinergic receptor, muscarinic 5 [Source:RefSeq_peptide;Acc:NP_001026721][hgnc]CHRM5
Xenopus_tropicalisone2one ENSXETG00000017868Muscarinic acetylcholine receptor M5 [Source:UniProtKB/Swiss-Prot;Acc:P08912][hgnc]
Danio_rerioone2many ENSDARG00000004026cholinergic receptor, muscarinic 5 [Source:RefSeq_peptide;Acc:NP_001018639][hgnc]chrm5
Gasterosteus_aculeatusone2many ENSGACG00000006035Muscarinic acetylcholine receptor M5 [Source:UniProtKB/Swiss-Prot;Acc:P08912][hgnc]
Tetraodon_nigroviridisone2many ENSTNIG00000017444Muscarinic acetylcholine receptor M5 [Source:UniProtKB/Swiss-Prot;Acc:P08912][hgnc]
Oryzias_latipesone2many ENSORLG00000016873Muscarinic acetylcholine receptor M5 [Source:UniProtKB/Swiss-Prot;Acc:P08912][hgnc]
Danio_rerioone2many ENSDARG00000069598Muscarinic acetylcholine receptor M5 [Source:UniProtKB/Swiss-Prot;Acc:P08912][hgnc]
Oryzias_latipesone2many ENSORLG00000017845Muscarinic acetylcholine receptor M5 [Source:UniProtKB/Swiss-Prot;Acc:P08912][hgnc]
Takifugu_rubripesone2one ENSTRUG00000018108Muscarinic acetylcholine receptor M5 [Source:UniProtKB/Swiss-Prot;Acc:P08912][hgnc]
Gasterosteus_aculeatusone2many ENSGACG00000007923Muscarinic acetylcholine receptor M5 [Source:UniProtKB/Swiss-Prot;Acc:P08912][hgnc]
Tetraodon_nigroviridisone2many ENSTNIG00000012213Muscarinic acetylcholine receptor M5 [Source:UniProtKB/Swiss-Prot;Acc:P08912][hgnc]