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Summary sheet information for GPCR 'MELANOCORTIN RECEPTORS_MC2_Homo sapiens'
Name MELANOCORTIN RECEPTORS_MC2_Homo sapiens
Description RecName: Full=Adrenocorticotropic hormone receptor; Short=ACTH receptor; Short=ACTH-R; Short=Adrenocorticotropin receptor;AltName: Full=Melanocortin receptor 2;AltName: Full=MC2-R
Class CLASS A
Family MELANOCORTIN RECEPTORS
Sub_family MC2
type
Protein features link Protein Information from Dasty2 DAS Client
GPCR, G-protein, Effector interaction Visualizaton of GPCR, G-protein, Effector interaction at protein level
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Genes
Gene Location:
Chromosome: 18
Gene Start: 13872043
Gene End: 13905535
Ensembl Contig View

Ensembl Genes:
ENSG00000185231

EMBL:
EMBL ID  Description
AB065915  Homo sapiens gene for seven transmembrane helix receptor, complete cds, isolate:CBRC7TM_478.
AK289381  Homo sapiens cDNA FLJ77879 complete cds, highly similar to H.sapiens ACTH-R gene for adrenocorticotropic hormone receptor.
AK315319  Homo sapiens cDNA, FLJ96352, Homo sapiens melanocortin 2 receptor (adrenocorticotropic hormone)(MC2R), mRNA.
AY225229  Homo sapiens melanocortin 2 receptor gene, complete cds.
BC069074  Homo sapiens melanocortin 2 receptor (adrenocorticotropic hormone), mRNA (cDNA clone MGC:95349 IMAGE:7216888), complete cds.
BC094710  Homo sapiens melanocortin 2 receptor (adrenocorticotropic hormone), mRNA (cDNA clone MGC:104423 IMAGE:30330087), complete cds.
BC104169  Homo sapiens melanocortin 2 receptor (adrenocorticotropic hormone), mRNA (cDNA clone MGC:125798 IMAGE:40030365), complete cds.
BC104170  Homo sapiens melanocortin 2 receptor (adrenocorticotropic hormone), mRNA (cDNA clone IMAGE:40030371), partial cds.
CH471113  Homo sapiens 211000035842422 genomic scaffold, whole genome shotgun sequence.
X65633  H.sapiens ACTH-R gene for adrenocorticotropic hormone receptor

EntrezGene:
ID  Description
MC2R  melanocortin 2 receptor (adrenocorticotropic hormone)

RefSeq DNA:
ID  Description
NM_000529  Homo sapiens melanocortin 2 receptor (adrenocorticotropic hormone) (MC2R), mRNA.

UniGene:
ID  Description
Hs.248144  CDNA FLJ77879 complete cds, highly similar to H.sapiens ACTH-R gene for adrenocorticotropic hormone receptor

Proteins
Ensembl Proteins:
ENSP00000382718; ENSP00000333821

Entrez Proteins:
AAH69074.1; AAH94710.1; AAI04170.1; AAI04171.1; AAO67714.1; BAC06130.1; BAF82070.1; BAG37722.1; CAA46587.1; EAX01503.1

RefSeq Proteins:
ID  Description
NP_000520  melanocortin 2 receptor [Homo sapiens].

UniProt:
ID  Description
A8K016  SubName: Full=cDNA FLJ77879, highly similar to H.sapiens ACTH-R adrenocorticotropic hormone receptor (HCG1647032) (cDNA, FLJ96352, Homo sapiens melanocortin 2 receptor (adrenocorticotropic hormone)(MC2R), mRNA);
Q01718  RecName: Full=Adrenocorticotropic hormone receptor; Short=ACTH receptor; Short=ACTH-R; Short=Adrenocorticotropin receptor; AltName: Full=Melanocortin receptor 2; AltName: Full=MC2-R;

Domains
SMART:
- Hyperlink to SMART; - Hyperlink to ENSEMBL

InterPro:
ID  Name
IPR001168  ACTH_rcpt
IPR000276  GPCR_Rhodpsn
IPR017452  GPCR_Rhodpsn_supfam
IPR001671  Melcrt_ACTH_rcpt

Pfam:
ID  Description
7tm_1  7 transmembrane receptor (rhodopsin family)

Structure
PDB:
ID

HSSP:
ID  Description

PSSH:
ID  Description
Q01718  UNKNOWN

Diseases
OMIM:
OMIM ID  Name  Alt Name
607397  MELANOCORTIN 2 RECEPTOR; MC2R   MC2 RECEPTOR ACTH RECEPTOR; ACTHR CORTICOTROPIN RECEPTOR

Gene Ontology
GO:
GO ID  Description
GO:0001584  rhodopsin-like receptor activity
GO:0004872  receptor activity
GO:0004949  cannabinoid receptor activity
GO:0004977  melanocortin receptor activity
GO:0004978  adrenocorticotropin receptor activity
GO:0005886  plasma membrane
GO:0005887  integral to plasma membrane
GO:0007165  signal transduction
GO:0007186  G-protein coupled receptor protein signaling pathway
GO:0007187  G-protein signaling, coupled to cyclic nucleotide second messenger
GO:0016021  integral to membrane

Pathway
KEGG:
KEGG PATHWAY ID  Name
hsa04080  Neuroactive ligand-receptor interaction

Panther:
ID  Description

Chemicals
DrugBank:
ID  Name  Synonyms
DB01284  Cosyntropin  Tetracosactide
DB01285  Corticotropin  ACTH; Adrenocorticotopin; Adrenocorticotropic hormone; Corticotrophin; Cortrophin
HMDB:
ID  Name  Synonyms
Other GPCR resources
Links to other GPCR resources
GPCRDB | GPCR-OKB | GLIDA
Orthology
Orthology Relations:
Gene Gene Description Organism Orthology type Orthologs Orthologs Description
ENSG00000185231 Adrenocorticotropic hormone receptor (ACTH receptor) (ACTH-R) (Adrenocorticotropin receptor) (Melanocortin receptor 2) (MC2-R) [Source:UniProtKB/Swiss-Prot;Acc:Q01718] Pan_troglodytesone2one ENSPTRG00000009892Melanocortin 2 receptor (Fragment). [Source:UniProtKB/TrEMBL;Acc:Q6J9J9][hgnc]MC2R
Pongo_pygmaeusone2one ENSPPYG00000008978Adrenocorticotropic hormone receptor (ACTH receptor) (ACTH-R) (Adrenocorticotropin receptor) (Melanocortin receptor 2) (MC2-R) [Source:UniProtKB/Swiss-Prot;Acc:Q01718][hgnc]
Macaca_mulattaone2one ENSMMUG00000016681Adrenocorticotropic hormone receptor (ACTH receptor) (ACTH-R) (Adrenocorticotropin receptor) (Melanocortin receptor 2) (MC2-R) [Source:UniProtKB/Swiss-Prot;Acc:Q01718][hgnc]
Microcebus_murinusone2one ENSMICG00000000869Adrenocorticotropic hormone receptor (ACTH receptor) (ACTH-R) (Adrenocorticotropin receptor) (Melanocortin receptor 2) (MC2-R) [Source:UniProtKB/Swiss-Prot;Acc:Q01718][hgnc]
Otolemur_garnettiione2one ENSOGAG00000011597Adrenocorticotropic hormone receptor (ACTH receptor) (ACTH-R) (Adrenocorticotropin receptor) (Melanocortin receptor 2) (MC2-R) [Source:UniProtKB/Swiss-Prot;Acc:Q01718][hgnc]
Tarsius_syrichtaone2one ENSTSYG00000012188Adrenocorticotropic hormone receptor (ACTH receptor) (ACTH-R) (Adrenocorticotropin receptor) (Melanocortin receptor 2) (MC2-R) [Source:UniProtKB/Swiss-Prot;Acc:Q01718][hgnc]
Loxodonta_africanaone2one ENSLAFG00000011821Adrenocorticotropic hormone receptor (ACTH receptor) (ACTH-R) (Adrenocorticotropin receptor) (Melanocortin receptor 2) (MC2-R) [Source:UniProtKB/Swiss-Prot;Acc:Q01718][hgnc]
Tupaia_belangerione2one ENSTBEG00000002351Adrenocorticotropic hormone receptor (ACTH receptor) (ACTH-R) (Adrenocorticotropin receptor) (Melanocortin receptor 2) (MC2-R) [Source:UniProtKB/Swiss-Prot;Acc:Q01718][hgnc]
Equus_caballusone2one ENSECAG00000003841Adrenocorticotropic hormone receptor (ACTH receptor) (ACTH-R) (Adrenocorticotropin receptor) (Melanocortin receptor 2) (MC2-R) [Source:UniProtKB/Swiss-Prot;Acc:Q01718][hgnc]LOC100057018
Myotis_lucifugusone2one ENSMLUG00000016946Adrenocorticotropic hormone receptor (ACTH receptor) (ACTH-R) (Adrenocorticotropin receptor) (Melanocortin receptor 2) (MC2-R) [Source:UniProtKB/Swiss-Prot;Acc:Q01718][hgnc]
Pteropus_vampyrusone2one ENSPVAG00000001112Adrenocorticotropic hormone receptor (ACTH receptor) (ACTH-R) (Adrenocorticotropin receptor) (Melanocortin receptor 2) (MC2-R) [Source:UniProtKB/Swiss-Prot;Acc:Q01718][hgnc]
Tursiops_truncatusone2one ENSTTRG00000016362Adrenocorticotropic hormone receptor (ACTH receptor) (ACTH-R) (Adrenocorticotropin receptor) (Melanocortin receptor 2) (MC2-R) [Source:UniProtKB/Swiss-Prot;Acc:Q01718][hgnc]
Procavia_capensisone2one ENSPCAG00000000649Adrenocorticotropic hormone receptor (ACTH receptor) (ACTH-R) (Adrenocorticotropin receptor) (Melanocortin receptor 2) (MC2-R) [Source:UniProtKB/Swiss-Prot;Acc:Q01718][hgnc]
Canis_familiarisone2one ENSCAFG00000000170Adrenocorticotropic hormone receptor (ACTH receptor) (ACTH-R) (Adrenocorticotropin receptor) (Melanocortin receptor 2) (MC2-R) [Source:UniProtKB/Swiss-Prot;Acc:Q01718][hgnc]MC2R
Bos_taurusone2one ENSBTAG00000011038Adrenocorticotropic hormone receptor (ACTH receptor) (ACTH-R) (Melanocortin receptor 2) (MC2-R) (Adrenocorticotropin receptor). [Source:UniProtKB/Swiss-Prot;Acc:P34974][hgnc]MC2R
Erinaceus_europaeusone2one ENSEEUG00000012657Adrenocorticotropic hormone receptor (ACTH receptor) (ACTH-R) (Adrenocorticotropin receptor) (Melanocortin receptor 2) (MC2-R) [Source:UniProtKB/Swiss-Prot;Acc:Q01718][hgnc]
Mus_musculusone2one ENSMUSG00000045569Adrenocorticotropic hormone receptor (ACTH receptor) (ACTH-R) (Adrenocorticotropin receptor) (Melanocortin receptor 2) (MC2-R) [Source:UniProtKB/Swiss-Prot;Acc:Q64326][hgnc]Mc2r
Rattus_norvegicusone2one ENSRNOG00000016681Adrenocorticotropic hormone receptor MC-2 (Fragment). [Source:UniProtKB/TrEMBL;Acc:Q8CIX6][hgnc]Mc2r
Cavia_porcellusone2one ENSCPOG00000010691Adrenocorticotropic hormone receptor (ACTH receptor) (ACTH-R) (Adrenocorticotropin receptor) (Melanocortin receptor 2) (MC2-R). [Source:UniProtKB/Swiss-Prot;Acc:Q9Z1S9][hgnc]
Sorex_araneusone2one ENSSARG00000012685Adrenocorticotropic hormone receptor (ACTH receptor) (ACTH-R) (Adrenocorticotropin receptor) (Melanocortin receptor 2) (MC2-R) [Source:UniProtKB/Swiss-Prot;Acc:Q01718][hgnc]
Monodelphis_domesticaone2one ENSMODG00000021413Adrenocorticotropic hormone receptor (ACTH receptor) (ACTH-R) (Adrenocorticotropin receptor) (Melanocortin receptor 2) (MC2-R) [Source:UniProtKB/Swiss-Prot;Acc:Q01718][hgnc]
Ornithorhynchus_anatinusone2one ENSOANG00000012498Adrenocorticotropic hormone receptor (ACTH receptor) (ACTH-R) (Adrenocorticotropin receptor) (Melanocortin receptor 2) (MC2-R) [Source:UniProtKB/Swiss-Prot;Acc:Q01718][hgnc]100076508
Gallus_gallusone2one ENSGALG00000013891melanocortin 2 receptor [Source:RefSeq_peptide;Acc:NP_001026686][hgnc]MC2R
Gasterosteus_aculeatusone2one ENSGACG00000003743Adrenocorticotropic hormone receptor (ACTH receptor) (ACTH-R) (Adrenocorticotropin receptor) (Melanocortin receptor 2) (MC2-R) [Source:UniProtKB/Swiss-Prot;Acc:Q01718][hgnc]
Takifugu_rubripesone2one ENSTRUG00000012951melanocortin 2 receptor [Source:RefSeq_peptide;Acc:NP_001027936][hgnc]MC2R
Tetraodon_nigroviridisone2one ENSTNIG00000006478Adrenocorticotropic hormone receptor (ACTH receptor) (ACTH-R) (Adrenocorticotropin receptor) (Melanocortin receptor 2) (MC2-R) [Source:UniProtKB/Swiss-Prot;Acc:Q01718][hgnc]
Danio_rerioone2one ENSDARG00000054949melanocortin 2 receptor [Source:RefSeq_peptide;Acc:NP_851302][hgnc]mc2r
Oryzias_latipesone2one ENSORLG00000004321Adrenocorticotropic hormone receptor (ACTH receptor) (ACTH-R) (Adrenocorticotropin receptor) (Melanocortin receptor 2) (MC2-R) [Source:UniProtKB/Swiss-Prot;Acc:Q01718][hgnc]