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Summary sheet information for Effector 'Phosphodiesterase 6-Homo sapiens-4'
Name Phosphodiesterase 6-Homo sapiens-4
Description "RecName: Full=Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma; Short=GMP-PDE gamma; EC=3.1.4.17;"
Class
Family Phosphodiesterases
Sub_family Rhodopsin-sensitive cGMP-specific PDEases
type Phosphodiesterase 6
Protein features link Protein Information from Dasty2 DAS Client
GPCR, G-protein, Effector interaction Visualizaton of GPCR, G-protein, Effector interaction at protein level
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Genes
Gene Location:
Chromosome: 17
Gene Start: 77227894
Gene End: 77234038
Ensembl Contig View

Ensembl Genes:
ENSG00000185527

EMBL:
EMBL ID  Description
BC106884  Homo sapiens phosphodiesterase 6G, cGMP-specific, rod, gamma, mRNA (cDNA clone MGC:125749 IMAGE:40029486), complete cds.
BX537414  Homo sapiens mRNA; cDNA DKFZp686N1686 (from clone DKFZp686N1686); complete cds
CH471099  Homo sapiens 211000035838146 genomic scaffold, whole genome shotgun sequence.
M36476  Human cGMP phosphodiesterase gamma-subunit (PDEG) mRNA, complete cds.
U00481  Homo sapiens gamma-subunit of rod cGMP-phosphodiesterase (PDEG) gene, exon 2.
U00482  Homo sapiens gamma-subunit of rod cGMP-phosphodiesterase (PDEG) gene, exons 3, 4 and complete cds.
X62025  Homo sapiens rod cG-PDE G gene for 3', 5'-cyclic nucleotide phosphodiesterase

EntrezGene:
ID  Description
PDE6G  phosphodiesterase 6G, cGMP-specific, rod, gamma

RefSeq DNA:
ID  Description
NM_002602  Homo sapiens phosphodiesterase 6G, cGMP-specific, rod, gamma (PDE6G), transcript variant 1, mRNA.

UniGene:
ID  Description
Hs.654482  CGMP phosphodiesterase gamma-subunit (PDEG)

Proteins
Ensembl Proteins:
ENSP00000328412; ENSP00000363875

Entrez Proteins:
AAA03653.1; AAA60044.1; AAI06885.1; CAA43975.1; CAD97656.1; EAW89666.1

RefSeq Proteins:
ID  Description
NP_002593  phosphodiesterase 6G, cGMP-specific, rod, gamma [Homo sapiens].

UniProt:
ID  Description
Q7Z3U8  SubName: Full=Putative uncharacterized protein DKFZp686N1686; SubName: Full=Phosphodiesterase 6G, cGMP-specific, rod, gamma; Flags: Fragment;
P18545  RecName: Full=Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma; Short=GMP-PDE gamma; EC=3.1.4.17;

Domains
SMART:
- Hyperlink to SMART; - Hyperlink to ENSEMBL

InterPro:
ID  Name
IPR006952  PDE6_gamma

Pfam:
ID  Description
PDE6_gamma  Retinal cGMP phosphodiesterase, gamma subunit

Structure
PDB:
ID

HSSP:
ID  Description
1fqj  SIGNALING PROTEIN
2ju4  HYDROLASE

PSSH:
ID  Description
Q7Z3U8  UNKNOWN
P18545  UNKNOWN

Diseases
OMIM:
OMIM ID  Name  Alt Name
180073  PHOSPHODIESTERASE 6G, cGMP-SPECIFIC, ROD, GAMMA; PDE6G   RETINAL ROD PHOTORECEPTOR cGMP PHOSPHODIESTERASE, GAMMA SUBUNIT; PDEG

Gene Ontology
GO:
GO ID  Description
GO:0000187  activation of MAPK activity
GO:0004114  3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0004857  enzyme inhibitor activity
GO:0005515  protein binding
GO:0007601  visual perception
GO:0016787  hydrolase activity
GO:0030553  cGMP binding
GO:0045742  positive regulation of epidermal growth factor receptor signaling pathway
GO:0045745  positive regulation of G-protein coupled receptor protein signaling pathway
GO:0050896  response to stimulus

Pathway
KEGG:
KEGG PATHWAY ID  Name
hsa00230  Purine metabolism

Panther:
ID  Description

Chemicals
DrugBank:
ID  Name  Synonyms
HMDB:
ID  Name  Synonyms
HMDB01397   GMP   5'-GMP; E 626; GMP; Guanidine monophosphate; Guanosine 5'-monophosphate; Guanosine 5'-phosphate; Guanosine 5'-phosphorate; Guanosine 5'-phosphoric acid; guanosine monophosphate; guanosine-5'-monophosphate; guanosine-5'-phosphate; guanosine-monophosphate; guanosine-phosphate; guanylate; guanylic acid
HMDB01314   Cyclic GMP   3',5'-cyclic GMP; 3',5'-guanosine; 3',5'-guanosine monophosphate; cGMP; cyclic 3',5'-guanosine monophosphate; cyclic GMP; cyclic-GMP; cyclic guanosine 3',5'-monophosphate; guanosine 3',5'-cyclic phosphate; guanosine 3',5'-cyclic-monophosphate; guanosine 3',5'-monophosphate; guanosine cyclic-monophosphate; guanosine-cyclic-phosphoric-acid
Orthology
Orthology Relations:
Gene Gene Description Organism Orthology type Orthologs Orthologs Description
ENSG00000185527 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (EC 3.1.4.17) (GMP-PDE gamma) [Source:UniProtKB/Swiss-Prot;Acc:P18545] Pongo_pygmaeusone2one ENSPPYG00000008739Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (EC 3.1.4.17) (GMP-PDE gamma) [Source:UniProtKB/Swiss-Prot;Acc:P18545][hgnc]
Macaca_mulattaone2one ENSMMUG00000001588Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (EC 3.1.4.17) (GMP-PDE gamma) [Source:UniProtKB/Swiss-Prot;Acc:P18545][hgnc]
Microcebus_murinusone2one ENSMICG00000008627Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (EC 3.1.4.17) (GMP-PDE gamma) [Source:UniProtKB/Swiss-Prot;Acc:P18545][hgnc]
Otolemur_garnettiione2one ENSOGAG00000011117Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (EC 3.1.4.17) (GMP-PDE gamma) [Source:UniProtKB/Swiss-Prot;Acc:P18545][hgnc]
Tupaia_belangerione2one ENSTBEG00000010593Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (EC 3.1.4.17) (GMP-PDE gamma) [Source:UniProtKB/Swiss-Prot;Acc:P18545][hgnc]
Cavia_porcellusone2one ENSCPOG00000022389Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (EC 3.1.4.17) (GMP-PDE gamma). [Source:UniProtKB/Swiss-Prot;Acc:Q9EQQ8][hgnc]
Felis_catusone2one ENSFCAG00000012923Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (EC 3.1.4.17) (GMP-PDE gamma). [Source:UniProtKB/Swiss-Prot;Acc:P61248][hgnc]
Canis_familiarisone2one ENSCAFG00000005767Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (EC 3.1.4.17) (GMP-PDE gamma). [Source:UniProtKB/Swiss-Prot;Acc:P54827][hgnc]PDE6G
Procavia_capensisone2one ENSPCAG00000005053Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (EC 3.1.4.17) (GMP-PDE gamma) [Source:UniProtKB/Swiss-Prot;Acc:P18545][hgnc]
Bos_taurusone2one ENSBTAG00000000354Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (EC 3.1.4.17) (GMP-PDE gamma). [Source:UniProtKB/Swiss-Prot;Acc:P04972][hgnc]PDE6G
Vicugna_pacosone2one ENSVPAG00000001544Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (EC 3.1.4.17) (GMP-PDE gamma) [Source:UniProtKB/Swiss-Prot;Acc:P18545][hgnc]
Dipodomys_ordiione2one ENSDORG00000008065Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (EC 3.1.4.17) (GMP-PDE gamma) [Source:UniProtKB/Swiss-Prot;Acc:P09174][hgnc]
Pteropus_vampyrusone2one ENSPVAG00000010995Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (EC 3.1.4.17) (GMP-PDE gamma) [Source:UniProtKB/Swiss-Prot;Acc:P18545][hgnc]
Tursiops_truncatusone2one ENSTTRG00000007604Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (EC 3.1.4.17) (GMP-PDE gamma) [Source:UniProtKB/Swiss-Prot;Acc:P18545][hgnc]
Mus_musculusone2one ENSMUSG00000025386Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (EC 3.1.4.17) (GMP-PDE gamma) [Source:UniProtKB/Swiss-Prot;Acc:P09174][hgnc]Pde6g
Spermophilus_tridecemlineatusone2one ENSSTOG00000000085Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (EC 3.1.4.17) (GMP-PDE gamma) [Source:UniProtKB/Swiss-Prot;Acc:P18545][hgnc]
Erinaceus_europaeusone2one ENSEEUG00000001383Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (EC 3.1.4.17) (GMP-PDE gamma) [Source:UniProtKB/Swiss-Prot;Acc:P18545][hgnc]
Equus_caballusone2one ENSECAG00000011977Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (EC 3.1.4.17) (GMP-PDE gamma) [Source:UniProtKB/Swiss-Prot;Acc:P18545][hgnc]LOC100055790
Ochotona_princepsone2one ENSOPRG00000015342Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (EC 3.1.4.17) (GMP-PDE gamma) [Source:UniProtKB/Swiss-Prot;Acc:P18545][hgnc]
Sorex_araneusone2one ENSSARG00000000230Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (EC 3.1.4.17) (GMP-PDE gamma) [Source:UniProtKB/Swiss-Prot;Acc:P18545][hgnc]
Monodelphis_domesticaone2one ENSMODG00000002709Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (EC 3.1.4.17) (GMP-PDE gamma) [Source:UniProtKB/Swiss-Prot;Acc:P18545][hgnc]
Ornithorhynchus_anatinusone2one ENSOANG00000002699Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (EC 3.1.4.17) (GMP-PDE gamma) [Source:UniProtKB/Swiss-Prot;Acc:P18545][hgnc]100090263
Gallus_gallusone2one ENSGALG00000004514phosphodiesterase 6G, cGMP-specific, rod, gamma [Source:RefSeq_peptide;Acc:NP_989776][hgnc]PDE6G
Xenopus_tropicalisone2one ENSXETG00000025321Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (EC 3.1.4.17) (GMP-PDE gamma) [Source:UniProtKB/Swiss-Prot;Acc:P18545][hgnc]
Takifugu_rubripesone2one ENSTRUG00000005502Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (EC 3.1.4.17) (GMP-PDE gamma) [Source:UniProtKB/Swiss-Prot;Acc:P18545][hgnc]
Tetraodon_nigroviridisone2one ENSTNIG00000011880Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (EC 3.1.4.17) (GMP-PDE gamma) [Source:UniProtKB/Swiss-Prot;Acc:P18545][hgnc]
Danio_rerioone2one ENSDARG00000022820phosphodiesterase 6G, cGMP-specific, rod, gamma [Source:RefSeq_peptide;Acc:NP_997964][hgnc]LOC791856
Gasterosteus_aculeatusone2one ENSGACG00000014432Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (EC 3.1.4.17) (GMP-PDE gamma) [Source:UniProtKB/Swiss-Prot;Acc:P18545][hgnc]
Oryzias_latipesone2one ENSORLG00000013791Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (EC 3.1.4.17) (GMP-PDE gamma) [Source:UniProtKB/Swiss-Prot;Acc:P18545][hgnc]
Pan_troglodytesone2one ENSPTRG00000009766Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (EC 3.1.4.17) (GMP-PDE gamma) [Source:UniProtKB/Swiss-Prot;Acc:P18545][hgnc]LOC746726