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Summary sheet information for Effector 'ATP-sensitive inward rectifier potassium channel 11-Homo sapiens'
Name ATP-sensitive inward rectifier potassium channel 11-Homo sapiens
Description "RecName: Full=ATP-sensitive inward rectifier potassium channel 11;AltName: Full=Potassium channel, inwardly rectifying subfamily J member 11;AltName: Full=Inward rectifier K(+) channel Kir6.2;AltName: Full=IKATP;"
Class
Family Ion channels
Sub_family ATP-sensitive inward rectifier potassium channels
type ATP-sensitive inward rectifier potassium channel 11
Protein features link Protein Information from Dasty2 DAS Client
GPCR, G-protein, Effector interaction Visualizaton of GPCR, G-protein, Effector interaction at protein level
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Genes
Gene Location:
Chromosome: 11
Gene Start: 17365042
Gene End: 17366214
Ensembl Contig View

Ensembl Genes:
ENSG00000187486

EMBL:
EMBL ID  Description
AK314943  Homo sapiens cDNA, FLJ95855, highly similar to Homo sapiens potassium inwardly-rectifying channel, subfamily J,member 11 (KCNJ11), mRNA.
BC064497  Homo sapiens potassium inwardly-rectifying channel, subfamily J, member 11, mRNA (cDNA clone MGC:71115 IMAGE:6279724), complete cds.
BC112358  Homo sapiens potassium inwardly-rectifying channel, subfamily J, member 11, mRNA (cDNA clone MGC:133230 IMAGE:40032947), complete cds.
D50582  Homo sapiens gene for inward rectifier K channel, complete cds.

EntrezGene:
ID  Description
KCNJ11  potassium inwardly-rectifying channel, subfamily J, member 11

RefSeq DNA:
ID  Description
NM_000525  Homo sapiens potassium inwardly-rectifying channel, subfamily J, member 11 (KCNJ11), mRNA.

UniGene:
ID  Description
Hs.248141  Homo sapiens, Similar to potassium inwardly-rectifying channel, subfamily J, member 11, clone IMAGE:5723755

Proteins
Ensembl Proteins:
ENSP00000345708

Entrez Proteins:
AAH64497.1; AAI12359.1; BAA09131.1; BAG37449.1

RefSeq Proteins:
ID  Description
NP_000516  potassium inwardly-rectifying channel J11 [Homo sapiens].

UniProt:
ID  Description
B2RC52  SubName: Full=cDNA, FLJ95855, highly similar to Homo sapiens potassium inwardly-rectifying channel, subfamily J,member 11 (KCNJ11), mRNA;
Q14654  RecName: Full=ATP-sensitive inward rectifier potassium channel 11; AltName: Full=Potassium channel, inwardly rectifying subfamily J member 11; AltName: Full=Inward rectifier K(+) channel Kir6.2; AltName: Full=IKATP;

Domains
SMART:
- Hyperlink to SMART; - Hyperlink to ENSEMBL
     ATP-sensitive inward rectifier potassium channel 11-Homo sapiens    

InterPro:
ID  Name
IPR016449  K_chnl_inward-rec_Kir
IPR003279  K_chnl_inward-rec_Kir6.2
IPR013521  K_chnl_inward-rec_Kir_Cr2
IPR013518  K_chnl_inward-rec_Kir_cyto
IPR001838  K_chnl_inward-rec_Kir-like

Pfam:
ID  Description
IRK  Inward rectifier potassium channel

Structure
PDB:
ID

HSSP:
ID  Description
1n9p  METAL TRANSPORT
1p7b  METAL TRANSPORT
1u4e  METAL TRANSPORT
1u4f  ALLERGEN
1xl4  METAL TRANSPORT
2e4f  TRANSPORT PROTEIN
2gix  METAL TRANSPORT
2qks  METAL TRANSPORT

PSSH:
ID  Description
Q14654  UNKNOWN

Diseases
OMIM:
OMIM ID  Name  Alt Name
600937  POTASSIUM CHANNEL, INWARDLY RECTIFYING, SUBFAMILY J, MEMBER 11; KCNJ11   POTASSIUM CHANNEL, INWARDLY RECTIFYING, BIR SUBUNIT BETA-CELL INWARD RECTIFIER SUBUNIT; BIR INWARDLY RECTIFYING POTASSIUM CHANNEL Kir6.2

Gene Ontology
GO:
GO ID  Description
GO:0005244  voltage-gated ion channel activity
GO:0005524  ATP binding
GO:0005739  mitochondrion
GO:0005783  endoplasmic reticulum
GO:0005792  microsome
GO:0005886  plasma membrane
GO:0006006  glucose metabolic process
GO:0006811  ion transport
GO:0006813  potassium ion transport
GO:0008022  protein C-terminus binding
GO:0008282  ATP-sensitive potassium channel complex
GO:0010107  potassium ion import
GO:0015272  ATP-activated inward rectifier potassium channel activity
GO:0016020  membrane
GO:0030315  T-tubule
GO:0030955  potassium ion binding
GO:0033198  response to ATP
GO:0042391  regulation of membrane potential
GO:0042493  response to drug
GO:0046676  negative regulation of insulin secretion
GO:0050877  neurological system process

Pathway
KEGG:
KEGG PATHWAY ID  Name
hsa04930  Type II diabetes mellitus

Panther:
ID  Description

Chemicals
DrugBank:
ID  Name  Synonyms
DB00661  Verapamil  Verapamil HCl; Verapamil [Usan:Ban:Inn]; Verapamilo [INN-Spanish]; Verapamilum [INN-Latin]
DB00922  Levosimendan  Levosimedan
DB01119  Diazoxide  
DB00222  Glimepiride  Glimepirid; Glimepirida; Glimepiridum; Glimepride
DB00912  Repaglinide  AG-EE 388 ZW; AG-EE 623 ZW; Repaglinida [INN-Spanish]; Repaglinidum [INN-Latin]; repaglinide
DB01016  Glibenclamide  Apo-Glibenclamide; Glibenclamida [INN-Spanish]; Glibenclamidum [INN-Latin]; Glyburide
DB00731  Nateglinide  Nateglinide [INN]; SDZ-DJN 608; nateglinide
DB01252  Mitiglinide  KAD-1229; Mitiglinide calcium hydrate; mitiglinide
DB00308  Ibutilide  Ibutilida [INN-Spanish]; Ibutilide; Ibutilide Fumarate; Ibutilidum [INN-Latin]
HMDB:
ID  Name  Synonyms
Orthology
Orthology Relations:
Gene Gene Description Organism Orthology type Orthologs Orthologs Description
ENSG00000187486 ATP-sensitive inward rectifier potassium channel 11 (Potassium channel, inwardly rectifying subfamily J member 11) (Inward rectifier K(+) channel Kir6.2) (IKATP) [Source:UniProtKB/Swiss-Prot;Acc:Q14654] Aedes_aegyptimany2many AAEL013373inwardly rectifying k+ channel,[hgnc]
Pan_troglodytesone2one ENSPTRG00000028707ATP-sensitive inward rectifier potassium channel 11 (Potassium channel, inwardly rectifying subfamily J member 11) (Inward rectifier K(+) channel Kir6.2) (IKATP) [Source:UniProtKB/Swiss-Prot;Acc:Q14654][hgnc]KCNJ11
Pongo_pygmaeusone2one ENSPPYG00000003452ATP-sensitive inward rectifier potassium channel 11 (Potassium channel, inwardly rectifying subfamily J member 11) (Inward rectifier K(+) channel Kir6.2) (IKATP) [Source:UniProtKB/Swiss-Prot;Acc:Q14654][hgnc]
Macaca_mulattaone2one ENSMMUG00000023580ATP-sensitive inward rectifier potassium channel 11 (Potassium channel, inwardly rectifying subfamily J member 11) (Inward rectifier K(+) channel Kir6.2) (IKATP) [Source:UniProtKB/Swiss-Prot;Acc:Q14654][hgnc]
Microcebus_murinusone2one ENSMICG00000005520ATP-sensitive inward rectifier potassium channel 11 (Potassium channel, inwardly rectifying subfamily J member 11) (Inward rectifier K(+) channel Kir6.2) (IKATP) [Source:UniProtKB/Swiss-Prot;Acc:Q14654][hgnc]
Equus_caballusone2one ENSECAG00000001643ATP-sensitive inward rectifier potassium channel 11 (Potassium channel, inwardly rectifying subfamily J member 11) (Inward rectifier K(+) channel Kir6.2) (IKATP) [Source:UniProtKB/Swiss-Prot;Acc:Q14654][hgnc]LOC100056520
Cavia_porcellusone2one ENSCPOG00000004142ATP-sensitive inward rectifier potassium channel 11 (Potassium channel, inwardly rectifying subfamily J member 11) (Inward rectifier K(+) channel Kir6.2) (IKATP). [Source:UniProtKB/Swiss-Prot;Acc:Q9JHJ9][hgnc]
Dipodomys_ordiione2one ENSDORG00000009601ATP-sensitive inward rectifier potassium channel 11 (Potassium channel, inwardly rectifying subfamily J member 11) (Inward rectifier K(+) channel Kir6.2) [Source:UniProtKB/Swiss-Prot;Acc:Q61743][hgnc]
Myotis_lucifugusone2one ENSMLUG00000012273ATP-sensitive inward rectifier potassium channel 11 (Potassium channel, inwardly rectifying subfamily J member 11) (Inward rectifier K(+) channel Kir6.2) (IKATP) [Source:UniProtKB/Swiss-Prot;Acc:Q14654][hgnc]
Canis_familiarisone2one ENSCAFG00000008730Inwardly rectifying potassium channel Kir6.2 subfamily J member 11 (Fragment). [Source:UniProtKB/TrEMBL;Acc:Q5BMM8][hgnc]KCNJ11
Bos_taurusone2one ENSBTAG00000016170Similar to potassium inward rectifier 6.2. [Source:UniProtKB/TrEMBL;Acc:A2VDS4][hgnc]KCNJ11
Procavia_capensisone2one ENSPCAG00000000428ATP-sensitive inward rectifier potassium channel 11 (Potassium channel, inwardly rectifying subfamily J member 11) (Inward rectifier K(+) channel Kir6.2) (IKATP) [Source:UniProtKB/Swiss-Prot;Acc:Q14654][hgnc]
Mus_musculusone2one ENSMUSG00000070561ATP-sensitive inward rectifier potassium channel 11 (Potassium channel, inwardly rectifying subfamily J member 11) (Inward rectifier K(+) channel Kir6.2) [Source:UniProtKB/Swiss-Prot;Acc:Q61743][hgnc]Kcnj11
Tursiops_truncatusone2one ENSTTRG00000015082ATP-sensitive inward rectifier potassium channel 11 (Potassium channel, inwardly rectifying subfamily J member 11) (Inward rectifier K(+) channel Kir6.2) (IKATP) [Source:UniProtKB/Swiss-Prot;Acc:Q14654][hgnc]
Felis_catusone2one ENSFCAG00000007305ATP-sensitive inward rectifier potassium channel 11 (Potassium channel, inwardly rectifying subfamily J member 11) (Inward rectifier K(+) channel Kir6.2) (IKATP) [Source:UniProtKB/Swiss-Prot;Acc:Q14654][hgnc]
Erinaceus_europaeusone2one ENSEEUG00000013033ATP-sensitive inward rectifier potassium channel 11 (Potassium channel, inwardly rectifying subfamily J member 11) (Inward rectifier K(+) channel Kir6.2) (IKATP) [Source:UniProtKB/Swiss-Prot;Acc:Q14654][hgnc]
Rattus_norvegicusone2one ENSRNOG00000021128ATP-sensitive inward rectifier potassium channel 11 (Potassium channel, inwardly rectifying subfamily J member 11) (Inward rectifier K(+) channel Kir6.2) (BIR). [Source:UniProtKB/Swiss-Prot;Acc:P70673][hgnc]Kcnj11
Ornithorhynchus_anatinusone2one ENSOANG00000007682ATP-sensitive inward rectifier potassium channel 11 (Potassium channel, inwardly rectifying subfamily J member 11) (Inward rectifier K(+) channel Kir6.2) (IKATP) [Source:UniProtKB/Swiss-Prot;Acc:Q14654][hgnc]
Monodelphis_domesticaone2one ENSMODG00000007004ATP-sensitive inward rectifier potassium channel 11 (Potassium channel, inwardly rectifying subfamily J member 11) (Inward rectifier K(+) channel Kir6.2) (IKATP) [Source:UniProtKB/Swiss-Prot;Acc:Q14654][hgnc]
Gallus_gallusone2one ENSGALG00000020505ATP-sensitive inward rectifier potassium channel 11 (Potassium channel, inwardly rectifying subfamily J member 11) (Inward rectifier K(+) channel Kir6.2) (IKATP) [Source:UniProtKB/Swiss-Prot;Acc:Q14654][hgnc]LOC428846
Tetraodon_nigroviridisone2one ENSTNIG00000006645ATP-sensitive inward rectifier potassium channel 11 (Potassium channel, inwardly rectifying subfamily J member 11) (Inward rectifier K(+) channel Kir6.2) (IKATP) [Source:UniProtKB/Swiss-Prot;Acc:Q14654][hgnc]
Takifugu_rubripesone2one ENSTRUG00000007184ATP-sensitive inward rectifier potassium channel 11 (Potassium channel, inwardly rectifying subfamily J member 11) (Inward rectifier K(+) channel Kir6.2) (IKATP) [Source:UniProtKB/Swiss-Prot;Acc:Q14654][hgnc]
Gasterosteus_aculeatusone2one ENSGACG00000011042ATP-sensitive inward rectifier potassium channel 11 (Potassium channel, inwardly rectifying subfamily J member 11) (Inward rectifier K(+) channel Kir6.2) (IKATP) [Source:UniProtKB/Swiss-Prot;Acc:Q14654][hgnc]
Danio_rerioone2one ENSDARG00000051880potassium inwardly-rectifying channel, subfamily J, member 11 [Source:RefSeq_peptide;Acc:NP_001034916][hgnc]kcnj11
Aedes_aegyptimany2many AAEL008932inwardly rectifying k+ channel,[hgnc]
Drosophila_melanogastermany2many FBgn0039061[hgnc]Ir
Anopheles_gambiaemany2many AGAP001280[hgnc]AgaP_ENSANGG00000017854
Drosophila_melanogastermany2many FBgn0039081[hgnc]Irk2
Aedes_aegyptimany2many AAEL008928inwardly rectifying k+ channel,[hgnc]
Anopheles_gambiaemany2many AGAP001283[hgnc]AgaP_ENSANGG00000017795
Anopheles_gambiaemany2many AGAP001281[hgnc]AgaP_ENSANGG00000020396
Anopheles_gambiaemany2many AGAP001284[hgnc]AgaP_ENSANGG00000024811
Caenorhabditis_elegansmany2many M02A10.2irk-2 encodes an inwardly rectifying potassium channel based on sequence homology to the the human potassium channel genes KCNJ1/KCNJ2. [Source: WormBase][hgnc]irk-2
Aedes_aegyptimany2many AAEL008931inwardly rectifying k+ channel,[hgnc]
Caenorhabditis_elegansmany2many R03E9.4Inward rectifier potassium channel irk-1. [Source:UniProtKB/Swiss-Prot;Acc:P52192][hgnc]irk-1