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Summary sheet information for Effector 'Tubulin-Homo sapiens-10'
Name Tubulin-Homo sapiens-10
Description RecName: Full=Tubulin beta chain;AltName: Full=Tubulin beta-5 chain
Class
Family Tubulins
Sub_family Tubulins
type Tubulin
Protein features link Protein Information from Dasty2 DAS Client
GPCR, G-protein, Effector interaction Visualizaton of GPCR, G-protein, Effector interaction at protein level
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Genes
Gene Location:
Chromosome: 6
Gene Start: 30796136
Gene End: 30801182
Ensembl Contig View

Ensembl Genes:
ENSG00000196230

EMBL:
EMBL ID  Description
AB062393  Homo sapiens OK/SW-cl.56 mRNA for beta 5-tubulin, complete cds.
AB088100  Homo sapiens TUBB gene for tubulin, beta polypeptide, complete cds.
AB103606  Homo sapiens TUBB gene for beta-tubulin protein, complete cds.
AB202098  Homo sapiens OK/SW-cl.56 gene for beta 5-tubulin, complete cds.
AF070561  Homo sapiens clone 24703 beta-tubulin mRNA, complete cds.
AF070593  Homo sapiens clones 24609 and 24716 beta-tubulin mRNA, complete cds.
AF070600  Homo sapiens clone 24464 beta-tubulin mRNA, complete cds.
AF141349  Homo sapiens beta-tubulin mRNA, complete cds.
AL662797  Human DNA sequence from clone XXbac-252P9 on chromosome 6 Contains the 3' end of the KIAA1949 gene for KIAA1949, the NRM gene for nurim (nuclear envelope membrane protein), the ribosomal protein L7 pseudogene 4 RPL7P4, the MDC1 gene for mediator of DNA damage checkpoint 1, a novel gene (XXbac-BPG27H4.7), the TUBB gene for tubulin beta polypeptide, the FLOT1 gene for flotillin 1, the IER3 gene for immediate early response 3, the HCG20 gene for HLA complex group 20, the C6orf214 gene for chromosome 6 open reading frame 214, a novel gene (XXbac-BPG27H4.8) and five CpG islands.
AL662848  Human DNA sequence from clone XXbac-111D4 on chromosome 6 Contains the ribosomal protein L7 pseudogene 4 RPL7P4, the MDC1 gene for mediator of DNA damage checkpoint 1, a novel gene (XXbac-BPG27H4.7), the TUBB gene for tubulin beta polypeptide, the FLOT1 gene for flotillin 1, the IER3 gene for immediate early response 3, the HCG20 gene for HLA complex group 20, the C6orf214 gene for chromosome 6 open reading frame 214, a novel gene (XXbac-BPG27H4.8), the TIGD1L gene for tigger transposable element derived 1-like and three CpG islands.
AL845353  Human DNA sequence from clone DAQB-47P19 on chromosome 6 Contains the 3' end of the MRPS18B gene for mitochondrial ribosomal protein S18B, the C6orf134 gene for chromosome 6 open reading frame 134, the prothymosin alpha pseudogene 1 (gene sequence 26) PTMAP1, the C6orf136 gene for chromosome 6 open reading frame 136, the DHX16 gene for DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 16, the KIAA1949 gene for KIAA1949, the NRM gene for nurim (nuclear envelope membrane protein), the ribosomal protein L7 pseudogene 4 RPL7P4 , the MDC1 gene for mediator of DNA damage checkpoint 1, the TUBB gene for tubulin beta polypeptide, the FLOT1 gene for flotillin 1, the IER3 gene for immediate early response 3 and 8 CpG islands.
BA000025  Homo sapiens genomic DNA, chromosome 6p21.3, HLA Class I region.
BC001896  Homo sapiens tubulin, beta, mRNA (cDNA clone IMAGE:3544415), partial cds.
BC001938  Homo sapiens tubulin, beta, mRNA (cDNA clone MGC:4101 IMAGE:2820585), complete cds.
BC002347  Homo sapiens tubulin, beta, mRNA (cDNA clone MGC:8668 IMAGE:2964461), complete cds.
BC005838  Homo sapiens tubulin, beta, mRNA (cDNA clone MGC:2440 IMAGE:2820585), complete cds.
BC007605  Homo sapiens tubulin, beta, mRNA (cDNA clone MGC:15683 IMAGE:3350604), complete cds.
BC013374  Homo sapiens tubulin, beta, mRNA (cDNA clone MGC:16435 IMAGE:3946253), complete cds.
BC015889  Homo sapiens tubulin, beta, mRNA (cDNA clone IMAGE:3922098), partial cds.
BC019924  Homo sapiens tubulin, beta, mRNA (cDNA clone MGC:30201 IMAGE:4998571), complete cds.
BC020946  Homo sapiens tubulin, beta, mRNA (cDNA clone MGC:26663 IMAGE:4795692), complete cds.
BC021909  Homo sapiens tubulin, beta, mRNA (cDNA clone MGC:15853 IMAGE:3509417), complete cds.
BC062532  Homo sapiens tubulin, beta, mRNA (cDNA clone IMAGE:3637650), complete cds.
BC070326  Homo sapiens tubulin, beta, mRNA (cDNA clone MGC:88329 IMAGE:6698679), complete cds.
BC103746  Homo sapiens tubulin, beta, mRNA (cDNA clone MGC:117247 IMAGE:6503977), complete cds.
BX248307  Human DNA sequence from clone DASS-191K16 on chromosome 6 Contains the MDC1 gene for mediator of DNA damage checkpoint 1, a novel gene (XXbac-BPG27H4.7), the TUBB gene for tubulin beta polypeptide, the FLOT1 gene for flotillin 1, the IER3 gene for immediate early response 3 and three CpG islands.
BX927283  Human DNA sequence from clone DAMA-26D6 on chromosome 6
CH471081  Homo sapiens 211000035843014 genomic scaffold, whole genome shotgun sequence.
CR759873  Human DNA sequence from clone DAAP-285E11 on chromosome 6
CR788240  Human DNA sequence from clone DAMC-316D20 on chromosome 6
CR936878  Human DNA sequence from clone DADB-118P11 on chromosome 6
DQ457058  Homo sapiens XTP3TPA-transactivated protein 1 (XTP3TPATP1) mRNA, XTP3TPATP1-S allele, complete cds.
EF036509  Homo sapiens beta-4 tubulin mRNA, partial cds.
J00314  Human beta-tubulin gene, clone m40.
V00599  Human mRNA fragment encoding beta-tubulin. (from clone D-beta-1)

EntrezGene:
ID  Description
LOC647000  similar to tubulin, beta 5
TUBB  tubulin, beta

RefSeq DNA:
ID  Description
NM_178014  Homo sapiens tubulin, beta (TUBB), mRNA.
NR_003598  Homo sapiens similar to tubulin, beta 5 (LOC442308), non-coding RNA.
XM_001718155  PREDICTED: Homo sapiens similar to tubulin, beta 5 (LOC647000), mRNA.
XM_001725146  PREDICTED: Homo sapiens similar to tubulin, beta 5 (LOC647000), mRNA.
XM_929980  PREDICTED: Homo sapiens similar to tubulin, beta 5 (LOC647000), mRNA.

UniGene:
ID  Description

Proteins
Ensembl Proteins:
ENSP00000379668; ENSP00000365578; ENSP00000379672; ENSP00000339001

Entrez Proteins:
AAB59507.1; AAC28642.1; AAC28650.1; AAC28654.1; AAD33873.1; AAH01896.1; AAH01938.1; AAH02347.1; AAH05838.1; AAH07605.1; AAH13374.1; AAH15889.1; AAH19924.1; AAH20946.1; AAH21909.1; AAH62532.1; AAH70326.1; AAI03747.1; ABE96641.1; ABO65095.1; BAB63321.1; BAB93480.1; BAC54932.1; BAE78618.1; BAF31267.1; CAA23844.1; CAI17441.1; CAI17442.1; CAI18196.1; CAI18197.1; CAI41892.1; CAI41893.1; CAI41894.1; CAM24851.1; CAM25516.1; CAM25933.1; CAM25934.1; CAM25935.1; CAQ06774.1; CAQ06775.1; CAQ06776.1; CAQ06818.1; CAQ06819.1; CAQ06820.1; CAQ07576.1; CAQ07577.1; CAQ07578.1; CAQ08695.1; CAQ08696.1; CAQ08697.1; EAX03322.1

RefSeq Proteins:
ID  Description
NP_821133  tubulin, beta [Homo sapiens].
XP_001718207  PREDICTED: similar to tubulin, beta 5 [Homo sapiens].
XP_001725198  PREDICTED: similar to tubulin, beta 5 [Homo sapiens].
XP_935073  PREDICTED: similar to tubulin, beta 5 [Homo sapiens].

UniProt:
ID  Description
A4UCU2  SubName: Full=Beta-4 tubulin; Flags: Fragment;
Q1KSF8  SubName: Full=XTP3TPA-transactivated protein 1;
Q5JP53  SubName: Full=Tubulin, beta polypeptide (Tubulin, beta);
Q5ST81  SubName: Full=Tubulin, beta (Tubulin beta polypeptide);
Q5SU16  SubName: Full=Beta 5-tubulin; SubName: Full=Beta-tubulin protein; SubName: Full=Tubulin beta polypeptide; SubName: Full=Tubulin, beta; SubName: Full=Tubulin, beta polypeptide; SubName: Full=Tubulin, beta, isoform CRA_a;
Q6LC01  SubName: Full=MRNA encoding beta-tubulin. (from clone D-beta-1); Flags: Fragment;
Q6P602  SubName: Full=TUBB protein;
Q96B85  SubName: Full=TUBB protein; Flags: Fragment;
Q9BUU9  SubName: Full=TUBB protein; Flags: Fragment;
P07437  RecName: Full=Tubulin beta chain; AltName: Full=Tubulin beta-5 chain;

Domains
SMART:
- Hyperlink to SMART; - Hyperlink to ENSEMBL
     Tubulin-Homo sapiens-10    

InterPro:
ID  Name
IPR008280  Tub_FtsZ_C
IPR013838  Beta-tubulin_BS
IPR002453  Beta_tubulin
IPR000217  Tubulin
IPR000158  Cell_division_FtsZ_N
IPR017975  Tubulin_CS
IPR003008  Tubulin_FtsZ
IPR010916  TonB_box_CS

Pfam:
ID  Description
Tubulin  Tubulin/FtsZ family, GTPase domain
Tubulin_C  Tubulin/FtsZ family, C-terminal domain

Structure
PDB:
ID

HSSP:
ID  Description
1ffx  STRUCTURAL PROTEIN
1ia0  TRANSPORT PROTEIN
1jff  STRUCTURAL PROTEIN
1sa0  CELL CYCLE
1sa1  CELL CYCLE
1tub  MICROTUBULES
1tvk  CELL CYCLE, STRUCTURAL PROTEIN
1z2b  CELL CYCLE
1z5v  STRUCTURAL PROTEIN
1z5w  STRUCTURAL PROTEIN
2btq  CYTOSKELETAL PROTEIN/COMPLEX
2hxf  TRANSPORT PROTEIN
2hxh  TRANSPORT PROTEIN
2p4n  TRANSPORT PROTEIN
3cb2  STRUCTURAL PROTEIN, HYDROLASE
3dco  MOTOR PROTEIN
3du7  CELL CYCLE
3e22  CELL CYCLE
3edl  STRUCTURAL PROTEIN

PSSH:
ID  Description
Q5JP53  UNKNOWN
Q5ST81  UNKNOWN
Q5SU16  UNKNOWN
Q6LC01  UNKNOWN
Q6P602  UNKNOWN
Q96B85  UNKNOWN
Q9BUU9  UNKNOWN
A4UCU2  UNKNOWN
Q1KSF8  UNKNOWN

Diseases
OMIM:
OMIM ID  Name  Alt Name
191130  TUBULIN, BETA; TUBB   M40

Gene Ontology
GO:
GO ID  Description
GO:0000166  nucleotide binding
GO:0003924  GTPase activity
GO:0005198  structural molecule activity
GO:0005200  structural constituent of cytoskeleton
GO:0005525  GTP binding
GO:0005737  cytoplasm
GO:0005856  cytoskeleton
GO:0005874  microtubule
GO:0005901  caveola
GO:0006928  cell motion
GO:0007017  microtubule-based process
GO:0007018  microtubule-based movement
GO:0016600  flotillin complex
GO:0042267  natural killer cell mediated cytotoxicity
GO:0042288  MHC class I protein binding
GO:0043234  protein complex
GO:0051225  spindle assembly
GO:0051258  protein polymerization

Pathway
KEGG:
KEGG PATHWAY ID  Name
hsa04540  Gap junction
hsa05130  Pathogenic Escherichia coli infection

Panther:
ID  Description
P00016  Cytoskeletal regulation by Rho GTPase
P00029  Huntington disease

Chemicals
DrugBank:
ID  Name  Synonyms
DB00541  Vincristine  22-Oxovincaleukoblastine; Indole alkaloid; LCR; Leurocristine; VCR; VIN; Vincristina [DCIT]; Vincristine Sulfate; Vincristinum [INN-Latin]; Vincrstine; Vincrystine; Z-D-Val-Lys(Z)-OH; vincristine
DB01873  Epothilone D  KOS-862; epothilone D
DB00361  Vinorelbine  Vinorelbin; Vinorelbina [Spanish]; Vinorelbine Bitartrate; Vinorelbine Ditartarate; Vinorelbine Ditartrate; Vinorelbine Tartrate; Vinorelbinum [Latin]; vinorelbine
DB00570  Vinblastine  
DB01394  Colchicine  Colchicin; Colchicina; Colchicinum
DB03010  Epothilone B  EPO 906; EPO906; patupilone
HMDB:
ID  Name  Synonyms
Orthology
Orthology Relations:
Gene Gene Description Organism Orthology type Orthologs Orthologs Description
ENSG00000196230 Tubulin beta chain (Tubulin beta-5 chain) [Source:UniProtKB/Swiss-Prot;Acc:P07437] Pan_troglodytesone2one ENSPTRG00000017939Tubulin beta chain (Tubulin beta-5 chain). [Source:UniProtKB/Swiss-Prot;Acc:Q7JJU6][hgnc]LOC740259
Pongo_pygmaeusone2one ENSPPYG00000016419Tubulin beta chain (Tubulin beta-5 chain). [Source:UniProtKB/Swiss-Prot;Acc:Q5R943][hgnc]
Macaca_mulattaone2one ENSMMUG00000023684Tubulin beta-2 chain. [Source:UniProtKB/Swiss-Prot;Acc:P69895][hgnc]574113
Equus_caballusone2one ENSECAG00000020234Tubulin beta chain (Tubulin beta-5 chain) [Source:UniProtKB/Swiss-Prot;Acc:P07437][hgnc]LOC100059595
Dipodomys_ordiione2one ENSDORG00000003209Tubulin beta-5 chain [Source:UniProtKB/Swiss-Prot;Acc:P99024][hgnc]
Felis_catusone2one ENSFCAG00000007697Tubulin beta chain (Tubulin beta-5 chain) [Source:UniProtKB/Swiss-Prot;Acc:P07437][hgnc]
Mus_musculusone2one ENSMUSG00000001525Tubulin beta-5 chain [Source:UniProtKB/Swiss-Prot;Acc:P99024][hgnc]Tubb5
Pteropus_vampyrusone2one ENSPVAG00000003989Tubulin beta chain (Tubulin beta-5 chain) [Source:UniProtKB/Swiss-Prot;Acc:P07437][hgnc]
Canis_familiarisone2one ENSCAFG00000000443Tubulin beta chain (Tubulin beta-5 chain) [Source:UniProtKB/Swiss-Prot;Acc:P07437][hgnc]LOC607735
Procavia_capensisapprent_one2one ENSPCAG00000017045Tubulin beta chain (Tubulin beta-5 chain) [Source:UniProtKB/Swiss-Prot;Acc:P07437][hgnc]
Rattus_norvegicusone2one ENSRNOG00000000821Tubulin beta-5 chain. [Source:UniProtKB/Swiss-Prot;Acc:P69897][hgnc]Tubb5
Ochotona_princepsone2one ENSOPRG00000014770Tubulin beta chain (Tubulin beta-5 chain) [Source:UniProtKB/Swiss-Prot;Acc:P07437][hgnc]
Cavia_porcellusone2one ENSCPOG00000012082Tubulin beta chain (Tubulin beta-5 chain) [Source:UniProtKB/Swiss-Prot;Acc:P07437][hgnc]
Oryctolagus_cuniculusapprent_one2one ENSOCUG00000002187Tubulin beta chain (Tubulin beta-5 chain) [Source:UniProtKB/Swiss-Prot;Acc:P07437][hgnc]
Monodelphis_domesticaone2one ENSMODG00000023805Tubulin beta chain (Tubulin beta-5 chain) [Source:UniProtKB/Swiss-Prot;Acc:P07437][hgnc]
Echinops_telfairiapprent_one2one ENSETEG00000013572Tubulin beta chain (Tubulin beta-5 chain) [Source:UniProtKB/Swiss-Prot;Acc:P07437][hgnc]
Otolemur_garnettiiapprent_one2one ENSOGAG00000008311Tubulin beta chain (Tubulin beta-5 chain) [Source:UniProtKB/Swiss-Prot;Acc:P07437][hgnc]
Tursiops_truncatusapprent_one2one ENSTTRG00000008946Tubulin beta chain (Tubulin beta-5 chain) [Source:UniProtKB/Swiss-Prot;Acc:P07437][hgnc]
Tetraodon_nigroviridisone2many ENSTNIG00000010441Tubulin beta chain (Tubulin beta-5 chain) [Source:UniProtKB/Swiss-Prot;Acc:P07437][hgnc]
Gasterosteus_aculeatusone2one ENSGACG00000009635Tubulin beta chain (Tubulin beta-5 chain) [Source:UniProtKB/Swiss-Prot;Acc:P07437][hgnc]
Xenopus_tropicalisone2one ENSXETG00000024084Tubulin, beta, 5. [Source:UniProtKB/TrEMBL;Acc:Q6GLE7][hgnc]
Myotis_lucifugusapprent_one2one ENSMLUG00000006286Tubulin beta chain (Tubulin beta-5 chain) [Source:UniProtKB/Swiss-Prot;Acc:P07437][hgnc]
Danio_rerioone2one ENSDARG00000037997tubulin, beta 5 [Source:RefSeq_peptide;Acc:NP_942113][hgnc]tubb5
Tetraodon_nigroviridisone2many ENSTNIG00000008014Tubulin beta chain (Tubulin beta-5 chain) [Source:UniProtKB/Swiss-Prot;Acc:P07437][hgnc]
Takifugu_rubripesone2one ENSTRUG00000012143Tubulin beta chain (Tubulin beta-5 chain) [Source:UniProtKB/Swiss-Prot;Acc:P07437][hgnc]
Oryzias_latipesone2one ENSORLG00000012987Tubulin beta chain (Tubulin beta-5 chain) [Source:UniProtKB/Swiss-Prot;Acc:P07437][hgnc]
Tupaia_belangeriapprent_one2one ENSTBEG00000004015Tubulin beta chain (Tubulin beta-5 chain) [Source:UniProtKB/Swiss-Prot;Acc:P07437][hgnc]
Drosophila_melanogastermany2many FBgn0003889[hgnc]betaTub85D
Drosophila_melanogastermany2many FBgn0003887[hgnc]betaTub56D
Anopheles_gambiaeone2many AGAP010929[hgnc]AgaP_ENSANGG00000010545
Aedes_aegyptione2many AAEL002851tubulin beta chain[hgnc]
Saccharomyces_cerevisiaeone2many YFL037WTubulin beta chain (Beta-tubulin). [Source:UniProtKB/Swiss-Prot;Acc:P02557][hgnc]TUB2