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Summary sheet information for GPCR 'HISTAMINE RECEPTORS_H1_Homo sapiens'
Name HISTAMINE RECEPTORS_H1_Homo sapiens
Description RecName: Full=Histamine H1 receptor
Class CLASS A
Family HISTAMINE RECEPTORS
Sub_family H1
type
Protein features link Protein Information from Dasty2 DAS Client
GPCR, G-protein, Effector interaction Visualizaton of GPCR, G-protein, Effector interaction at protein level
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Genes
Gene Location:
Chromosome: 3
Gene Start: 11269385
Gene End: 11280243
Ensembl Contig View

Ensembl Genes:
ENSG00000196639

EMBL:
EMBL ID  Description
AB041380  Homo sapiens gene for histamine H1 receptor, complete cds.
AF026261  Homo sapiens histamine H1 receptor mRNA, complete cds.
AK289412  Homo sapiens cDNA FLJ78350 complete cds, highly similar to Homo sapiens histamine receptor H1 (HRH1), mRNA.
AK292157  Homo sapiens cDNA FLJ78005 complete cds, highly similar to Homo sapiens histamine receptor H1 (HRH1), mRNA.
AK312879  Homo sapiens cDNA, FLJ93323, highly similar to Homo sapiens histamine receptor H1 (HRH1), mRNA.
AY136743  Homo sapiens histamine receptor H1 (HRH1) mRNA, complete cds.
BC060802  Homo sapiens histamine receptor H1, mRNA (cDNA clone MGC:71613 IMAGE:30340368), complete cds.
CH471055  Homo sapiens 211000035832932 genomic scaffold, whole genome shotgun sequence.
D14436  Homo sapiens gene for histamine H1 receptor, complete cds.
D28481  Homo sapiens mRNA for histamine H1 receptor, complete cds.
X76786  H.sapiens histamine H1 receptor gene.
Z34897  H.sapiens mRNA for H1 histamine receptor

EntrezGene:
ID  Description
HRH1  histamine receptor H1

RefSeq DNA:
ID  Description
NM_000861  Homo sapiens histamine receptor H1 (HRH1), transcript variant 4, mRNA.
NM_001098211  Homo sapiens histamine receptor H1 (HRH1), transcript variant 3, mRNA.
NM_001098212  Homo sapiens histamine receptor H1 (HRH1), transcript variant 2, mRNA.
NM_001098213  Homo sapiens histamine receptor H1 (HRH1), transcript variant 1, mRNA.

UniGene:
ID  Description
Hs.1570  Histamine H1 receptor

Proteins
Ensembl Proteins:
ENSP00000380247; ENSP00000347299

Entrez Proteins:
AAB95156.1; AAH60802.1; AAN01269.1; BAA03319.1; BAA05840.1; BAA94465.1; BAF82101.1; BAF84846.1; BAG35729.1; CAA54182.1; CAA84380.1; EAW64092.1

RefSeq Proteins:
ID  Description
NP_000852  histamine receptor H1 [Homo sapiens].
NP_001091681  histamine receptor H1 [Homo sapiens].
NP_001091682  histamine receptor H1 [Homo sapiens].
NP_001091683  histamine receptor H1 [Homo sapiens].

UniProt:
ID  Description
A8K047  SubName: Full=cDNA FLJ78350, highly similar to Homo sapiens histamine receptor H1 (HRH1), mRNA (Histamine receptor H1);
A8K7Z2  SubName: Full=cDNA FLJ78005, highly similar to Homo sapiens histamine receptor H1 (HRH1), mRNA;
B2R782  SubName: Full=cDNA, FLJ93323, highly similar to Homo sapiens histamine receptor H1 (HRH1), mRNA;
Q6P9E5  SubName: Full=Histamine receptor H1;
P35367  RecName: Full=Histamine H1 receptor;

Domains
SMART:
- Hyperlink to SMART; - Hyperlink to ENSEMBL

InterPro:
ID  Name
IPR017452  GPCR_Rhodpsn_supfam
IPR000921  Histamine_H1_recept
IPR000276  GPCR_Rhodpsn

Pfam:
ID  Description
7tm_1  7 transmembrane receptor (rhodopsin family)

Structure
PDB:
ID

HSSP:
ID  Description
2vt4  RECEPTOR
3eml  MEMBRANE PROTEIN, RECEPTOR

PSSH:
ID  Description
Q6P9E5  UNKNOWN
P35367  UNKNOWN

Diseases
OMIM:
OMIM ID  Name  Alt Name
600167  HISTAMINE RECEPTOR H1; HRH1   BPHS, MOUSE, HOMOLOG OF H1R

Gene Ontology
GO:
GO ID  Description
GO:0001584  rhodopsin-like receptor activity
GO:0004872  receptor activity
GO:0004969  histamine receptor activity
GO:0004981  muscarinic acetylcholine receptor activity
GO:0004983  neuropeptide Y receptor activity
GO:0005886  plasma membrane
GO:0005887  integral to plasma membrane
GO:0006954  inflammatory response
GO:0007165  signal transduction
GO:0007186  G-protein coupled receptor protein signaling pathway
GO:0007200  activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger
GO:0007268  synaptic transmission
GO:0016020  membrane
GO:0016021  integral to membrane
GO:0045429  positive regulation of nitric oxide biosynthetic process

Pathway
KEGG:
KEGG PATHWAY ID  Name
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction

Panther:
ID  Description
P00026  Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
P04385  Histamine H1 receptor mediated signaling pathway

Chemicals
DrugBank:
ID  Name  Synonyms
DB01403  Methotrimeprazine  Levomepromazine
DB01239  Chlorprothixene  Alpha-Chlorprothixene; CPT; CPX; Chloroprothixene; Chlorprothixen; Chlorprothixine; Chlorprotixen; Chlorprotixene; Chlorprotixine; Chlothixen; Cis-Chlorprothixene
DB00716  Nedocromil  
DB00334  Olanzapine  olanzapine
DB00902  Methdilazine  MD; Methdilazine Hcl; Methdilazine Monohydrochloride; Methdilazine hydrochloride; Methdilazinum [INN-Latin]; Methilazine hydrochloride; Methodilazine; Metodilazina [INN-Spanish]
DB00719  Azatadine  Azatadina [INN-Spanish]; Azatadine Maleate; Azatadinum [INN-Latin]; Azatidine
DB01151  Desipramine  DMI; Demethylimipramine; Desimipramine; Desimpramine; Desipramin; Desipramine Hcl; Desmethylimipramine; Dezipramine; Dimethylimipramine; Methylaminopropyliminodibenzyl; Monodemethylimipramine; Norimipramine; Norpramine
DB00557  Hydroxyzine  Hidroxizina [INN-Spanish]; Hydroksyzyny [Polish]; Hydroxine; Hydroxizine; Hydroxizinum; Hydroxycine; Hydroxyzin; Hydroxyzine Base; Hydroxyzine Hcl; Hydroxyzine Pamoate; Hydroxyzinum [INN-Latin]; Hydroxyzyne; Idrossizina [Dcit]
DB06148  Mianserin  Mianserina [inn-spanish]; Mianserine; Mianserine [inn-french]; Mianserinum [inn-latin]; Mianseryna [polish]
DB00656  Trazodone  Trazodona [INN-Spanish]; Trazodone Hcl; Trazodone Hydrochloride; Trazodonum [INN-Latin]; trazodone
DB01237  Bromodiphenhydramine  Ambodryl Hydrochloride; Amodryl; Bromanautine; Bromazin; Bromazine; Bromazine hydrochloride; Bromdiphenhydramine; Bromdiphenhydramine hydrochloride; Bromdiphenylhydramine Hydrochloride; Bromodiphenhydramine hydrochloride
DB00885  Pemirolast  Pemirolast Potassium; Pemirolastum [INN-Latin]; Pemiroplast Potassium
DB04837  Chlophedianol  1-(2-Chlorophenyl)-3-(dimethylamino)-1-phenyl-1-propanol; 1-Phenyl-1-(o-chlorophenyl)-3-dimethylaminopropanol; 2-Chloro-alpha-(2-(dimethylamino)ethyl)benzhydrol; Alpha-(dimethylaminoethyl)-o-chlorobenzhydrol; Chlofedanol; Clofedano; Clofedanol; Clofedanolum [inn-latin]; Clofedianolo [italian]; Clophedianol base
DB00667  Histamine Phosphate  
DB01142  Doxepin  Doxepin Hcl; Doxepin, Hydrochloride; Doxepina [INN-Spanish]; Doxepine; Doxepinum [INN-Latin]
DB00283  Clemastine  Clemastina [INN-Spanish]; Clemastine Fumarate; Clemastinum [INN-Latin]
DB00568  Cinnarizine  
DB01173  Orphenadrine  Mephenamine; O-Methyldiphenhydramine; Orphenadine; Orphenadrin; Orphenadrine Citrate; Orphenate; Orphenedrine
DB00370  Mirtazapine  Mepirzepine; Mirtazapina [INN-Spanish]; Mirtazapine [Usan:Ban:Inn]; Mirtazapinum [INN-Latin]; Mirtazepine; mirtazapine
DB04841  Flunarizine  (E)-1-[Bis-(p-fluorophenyl)methyl]-4-cinnamylpiperazine; 1-(Bis(4-fluorophenyl)methyl)-4-cinnamylpiperazine; Flunarizina [inn-spanish]; Flunarizine Hydrochloride; Flunarizinum [inn-latin]; flunarizine dihydrochloride
DB00768  Olopatadine  
DB01075  Diphenhydramine  Diphenhydramine Base; Diphenhydramine Hcl; Diphenhydramine Salicylate; Diphenylhydramine
DB01176  Cyclizine  Ciclizina [INN-Spanish]; Cyclizine Chloride; Cyclizine Hydrochloride; Cyclizinum [INN-Latin]
DB01224  Quetiapine  
DB00792  Tripelennamine  
DB00405  Dexbrompheniramine  D-Brompheniramine; Parabromdylamine; Parabromodylamine
DB00737  Meclizine  
DB00767  Benzquinamide  
DB00920  Ketotifen  Ketotifen Fumarate; Ketotifene [INN-French]; Ketotifene fumarate; Ketotifeno [INN-Spanish]; Ketotifenum [INN-Latin]
DB00434  Cyproheptadine  
DB00246  Ziprasidone  Ziprasidone hydrochloride; Ziprasidone mesylate trihydrate
DB00835  Brompheniramine  Brompheniramine Maleate
DB00342  Terfenadine  Ternadin
DB00363  Clozapine  Clozapin
DB01084  Emedastine  Emedastina [INN-Spanish]; Emedastine difumarate; Emedastinum [INN-Latin]
DB01106  Levocabastine  Levocabastin; Levocabastina [Spanish]; Levocabastinum [Latin]
DB00427  Triprolidine  
DB00748  Carbinoxamine  Carbinoxamine Maleate; Paracarbinoxamine; Paracarinoxamine
DB00354  Buclizine  Buclizina [INN-Spanish]; Buclizine Dihydrochloride; Buclizine Hydrochloride; Buclizinum [INN-Latin]; Histabutyzine Dihydrochloride; Vibazine Hydrochloride
DB00967  Desloratadine  Descarboethoxyloratadine; Descarboethoxyoratidine; Desloratidine; desloratadine
DB04890  Bepotastine  Bepotastine besilate; Betotastine besilate; TAU-284DS; bepotastine
DB00950  Fexofenadine  Carboxyterfenadine; Fexofenadine hydrochloride; Fexofendine; Terfenadine acid metabolite; Terfenadine carboxylate; Terfenadine-COOH
DB00734  Risperidone  Risperidona [Spanish]; Risperidonum [Latin]; risperdone; risperidone
DB01146  Diphenylpyraline  Diphenylpyralamine; Diphenylpyraline Hydrochloride; Diphenylpyrilene
DB00637  Astemizole  
DB01615  Aceprometazine  10-(2-(Dimethylamino)propyl)phenothiazin-2-yl methyl ketone; Aceprometazina [inn-spanish]; Aceprometazinum [inn-latin]; Acepromethazine
DB01069  Promethazine  Isopromethazine; Lilly 1516; Proazaimine; Proazamine; Promazinamide; Promethazin; Promethazine Hcl; Promethiazine; Promezathine; Prothazin; Prothazine
DB00455  Loratadine  Loratadina [Spanish]; Loratadinum [Latin]
DB00985  Dimenhydrinate  Diphenhydramine Theoclate; Diphenhydrinate
DB00433  Prochlorperazine  Chlormeprazine; Chlorperazine; Prochloroperazine; Prochlorpemazine; Prochlorperazin; Prochlorperazine edisylate; Prochlorperazine maleate; Prochlorpromazine; Procloperazine; Proclorperazine
DB00366  Doxylamine  Dossilamina [DCIT]; Doxilminio [INN-Spanish]; Doxylaminum [INN-Latin]
DB00372  Thiethylperazine  Ethylthioperazine; Theithylperazine
DB01071  Mequitazine  Mequitazina [INN-Spanish]; Mequitazina [Spanish]; Mequitazinum [INN-Latin]
DB00341  Cetirizine  Cetirizina [Spanish]; Cetirizinum [Latin]; Cetrizine Hcl
DB01620  Pheniramine  1-Phenyl-1-(2-pyridyl)-3-dimethylaminopropane; 2-(3-Dimethylamino-1-phenylpropyl)pyridine; 2-(alpha-(2-Dimethylaminoethyl)benzyl)pyridine; 2-[.alpha.-(2-Dimethylaminoethyl)benzyl]pyridine; 2-[.alpha.-[2-(Dimethylamino)ethyl]benzyl]pyridine; Dimethyl(3-phenyl-3-(2-pyridyl)propyl)amine; Feniramina [inn-spanish]; Feniramine; Pheniraminum [inn-latin]; Propheniramine; Prophenpyridamine
DB01619  Phenindamine  Fenindamina [inn-spanish]; Phenindaminum [inn-latin]; Phenindiamine
DB00751  Epinastine  Epinastina [Spanish]; Epinastinum [Latin]; epinastine
DB00972  Azelastine  Azelastina [INN-Spanish]; Azelastinum [INN-Latin]
DB01246  Trimeprazine  (+-)-Alimemazine; (+-)-Trimeprazine; Alimemazine; Alimemazine S,S-dioxide; Bayer 1219; Methylpromazine; Oxomemazin; Oxomemazina [INN-Spanish]; Oxomemazine; Oxomemazine [DCF:INN]; Oxomemazinum [INN-Latin]; Oxymemazine; Trimeperazine; Trimeprazine 5,5-dioxide; Trimeprazine Tartrat; Trimeprazine Tartrate; Trimeprazine hemi-(+)tartrate
DB00934  Maprotiline  Maprotilina [INN-Spanish]; Maprotiline Hcl; Maprotilinum [INN-Latin]; Maprotylina [Polish]
DB01114  Chlorpheniramine  Chloropheniramine; Chlorophenylpyridamin; Chlorophenylpyridamine; Chloroprophenpyridamine; Chlorphenamine; Chlorpheniramine Maleate; Chlorprophenpyridamine; Clorfeniramina; Dexchlorpheniramine; Dexchlorpheniramine Maleate
HMDB:
ID  Name  Synonyms
Other GPCR resources
Links to other GPCR resources
GPCRDB | GPCR-OKB | GLIDA
Orthology
Orthology Relations:
Gene Gene Description Organism Orthology type Orthologs Orthologs Description
ENSG00000196639 Histamine H1 receptor [Source:UniProtKB/Swiss-Prot;Acc:P35367] Pan_troglodytesone2one ENSPTRG00000030304Histamine H1 receptor. [Source:UniProtKB/Swiss-Prot;Acc:Q9N2B2][hgnc]HRH1
Pongo_pygmaeusone2one ENSPPYG00000013653Histamine H1 receptor. [Source:UniProtKB/Swiss-Prot;Acc:Q9N2B0][hgnc]
Macaca_mulattaone2one ENSMMUG00000004817Histamine H1 receptor [Source:UniProtKB/Swiss-Prot;Acc:P35367][hgnc]
Microcebus_murinusone2many ENSMICG00000016542[hgnc]
Microcebus_murinusone2many ENSMICG00000006607[hgnc]
Tarsius_syrichtaone2one ENSTSYG00000010377Histamine H1 receptor [Source:UniProtKB/Swiss-Prot;Acc:P35367][hgnc]
Equus_caballusone2one ENSECAG00000004544histamine H1 receptor [Source:RefSeq_peptide;Acc:NP_001075388][hgnc]HRH1
Pteropus_vampyrusone2one ENSPVAG00000007443Histamine H1 receptor [Source:UniProtKB/Swiss-Prot;Acc:P35367][hgnc]
Otolemur_garnettiione2one ENSOGAG00000016172Histamine H1 receptor [Source:UniProtKB/Swiss-Prot;Acc:P35367][hgnc]
Canis_familiarisone2one ENSCAFG00000005023Histamine H1 receptor [Source:UniProtKB/Swiss-Prot;Acc:P35367][hgnc]
Dasypus_novemcinctusone2one ENSDNOG00000011231Histamine H1 receptor [Source:UniProtKB/Swiss-Prot;Acc:P35367][hgnc]
Tupaia_belangerione2one ENSTBEG00000015981Histamine H1 receptor [Source:UniProtKB/Swiss-Prot;Acc:P35367][hgnc]
Bos_taurusone2one ENSBTAG00000001447Histamine H1 receptor. [Source:UniProtKB/Swiss-Prot;Acc:P30546][hgnc]HRH1
Spermophilus_tridecemlineatusone2one ENSSTOG00000015286Histamine H1 receptor [Source:UniProtKB/Swiss-Prot;Acc:P35367][hgnc]
Procavia_capensisone2one ENSPCAG00000009593Histamine H1 receptor [Source:UniProtKB/Swiss-Prot;Acc:P35367][hgnc]
Echinops_telfairione2one ENSETEG00000020202Histamine H1 receptor [Source:UniProtKB/Swiss-Prot;Acc:P35367][hgnc]
Oryctolagus_cuniculusone2one ENSOCUG00000001906Histamine H1 receptor [Source:UniProtKB/Swiss-Prot;Acc:P35367][hgnc]
Mus_musculusone2one ENSMUSG00000053004Histamine H1 receptor [Source:UniProtKB/Swiss-Prot;Acc:P70174][hgnc]Hrh1
Rattus_norvegicusone2one ENSRNOG00000007420Histamine H1 receptor. [Source:UniProtKB/Swiss-Prot;Acc:P31390][hgnc]Hrh1
Cavia_porcellusone2one ENSCPOG00000002743Histamine H1 receptor. [Source:UniProtKB/Swiss-Prot;Acc:P31389][hgnc]
Ornithorhynchus_anatinusone2one ENSOANG00000000983Histamine H1 receptor [Source:UniProtKB/Swiss-Prot;Acc:P35367][hgnc]100073660
Xenopus_tropicalisone2one ENSXETG00000007717Histamine H1 receptor [Source:UniProtKB/Swiss-Prot;Acc:P35367][hgnc]
Gallus_gallusone2one ENSGALG00000004930Histamine H1 receptor (Fragment). [Source:UniProtKB/TrEMBL;Acc:A2ICM7][hgnc]
Gasterosteus_aculeatusone2one ENSGACG00000007333Histamine H1 receptor [Source:UniProtKB/Swiss-Prot;Acc:P35367][hgnc]
Danio_rerioone2one ENSDARG00000052425histamine receptor H1 [Source:RefSeq_peptide;Acc:NP_001036196][hgnc]hrh1
Oryzias_latipesone2one ENSORLG00000004554Histamine H1 receptor [Source:UniProtKB/Swiss-Prot;Acc:P35367][hgnc]
Tetraodon_nigroviridisone2one ENSTNIG00000014808Histamine H1 receptor [Source:UniProtKB/Swiss-Prot;Acc:P35367][hgnc]
Takifugu_rubripesone2one ENSTRUG00000003853Histamine H1 receptor [Source:UniProtKB/Swiss-Prot;Acc:P35367][hgnc]