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Summary sheet information for Effector 'LARG RhoGEF-Homo sapiens'
Name LARG RhoGEF-Homo sapiens
Description RecName: Full=Rho guanine nucleotide exchange factor 12;AltName: Full=Leukemia-associated RhoGEF
Class
Family Guanine nucleotide exchange factors
Sub_family RhoGEFs
type LARG RhoGEF
Protein features link Protein Information from Dasty2 DAS Client
GPCR, G-protein, Effector interaction Visualizaton of GPCR, G-protein, Effector interaction at protein level
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Genes
Gene Location:
Chromosome: 11
Gene Start: 119713156
Gene End: 119865855
Ensembl Contig View

Ensembl Genes:
ENSG00000196914

EMBL:
EMBL ID  Description
AB002380  Homo sapiens mRNA for KIAA0382 protein, partial cds.
AF180681  Homo sapiens guanine nucleotide exchange factor (LARG) mRNA, complete cds.
BC063117  Homo sapiens Rho guanine nucleotide exchange factor (GEF) 12, mRNA (cDNA clone IMAGE:30353240), partial cds.

EntrezGene:
ID  Description
ARHGEF12  Rho guanine nucleotide exchange factor (GEF) 12

RefSeq DNA:
ID  Description
NM_015313  Homo sapiens Rho guanine nucleotide exchange factor (GEF) 12 (ARHGEF12), mRNA.

UniGene:
ID  Description
Hs.24598  KIAA0382 protein
Hs.621937  Transcribed locus

Proteins
Ensembl Proteins:
ENSP00000349056; ENSP00000380942

Entrez Proteins:
AAF36817.1; AAH63117.1; BAA20836.2

RefSeq Proteins:
ID  Description
NP_056128  Rho guanine nucleotide exchange factor (GEF) 12 [Homo sapiens].

UniProt:
ID  Description
Q9NZN5-2  UNKNOWN
Q9NZN5  RecName: Full=Rho guanine nucleotide exchange factor 12; AltName: Full=Leukemia-associated RhoGEF;

Domains
SMART:
- Hyperlink to SMART; - Hyperlink to ENSEMBL

InterPro:
ID  Name
IPR015212  Regulat_G_prot_signal-like
IPR001331  GDS_CDC24_CS
IPR001478  PDZ
IPR000219  DH-domain
IPR011993  PH_type
IPR001849  PH
IPR015721  RhoGEF_like

Pfam:
ID  Description
PDZ  PDZ domain (Also known as DHR or GLGF)
RhoGEF  RhoGEF domain
RGS-like  Regulator of G protein signalling-like domain

Structure
PDB:
ID
1TXD
1X86
2OMJ
2OS6

HSSP:
ID  Description
1d5g  HYDROLASE
1gq5  SIGNALING PROTEIN
1htj  SIGNALING PROTEIN
1iap  SIGNALING PROTEIN
1q3o  PEPTIDE BINDING PROTEIN
1q3p  PEPTIDE BINDING PROTEIN
1shz  SIGNALING PROTEIN
1txd  SIGNALING PROTEIN
1u39  PROTEIN TRANSPORT
1ueq  SIGNALING PROTEIN
1wf8  PROTEIN BINDING
1wfv  SIGNALING PROTEIN
1wha  SIGNALING PROTEIN
1x5q  CELL ADHESION, CELL CYCLE
1x86  SIGNALING PROTEIN/MEMBRANE PROTEIN
1xcg  SIGNALING PROTEIN ACTIVATOR/SIGNALING PR
1y7n  PROTEIN TRANSPORT
2awu  MEMBRANE PROTEIN
2aww  MEMBRANE PROTEIN
2awx  MEMBRANE PROTEIN
2byg  SIGNAL TRANSDUCTION
2csj  CELL ADHESION
2djt  SIGNALING PROTEIN
2dkr  PROTEIN TRANSPORT
2dls  SIGNALING PROTEIN
2eeh  METAL BINDING PROTEIN
2eei  METAL BINDING PROTEIN
2eej  METAL BINDING PROTEIN
2egk  PROTEIN BINDING
2egn  PROTEIN BINDING
2ego  PROTEIN BINDING
2eno  ENDOCYTOSIS
2f5y  SIGNALING PROTEIN
2fcf  STRUCTURAL PROTEIN
2fe5  STRUCTURAL PROTEIN
2fn5  SIGNALING PROTEIN
2fne  STRUCTURAL GENOMICS, UNKNOWN FUNCTION
2g2l  MEMBRANE PROTEIN
2he4  STRUCTURAL GENOMICS, UNKNOWN FUNCTION
2i04  PEPTIDE BINDING PROTEIN
2i0l  PEPTIDE BINDING PROTEIN
2iwn  SIGNALING PROTEIN
2jik  MEMBRANE PROTEIN
2jil  MEMBRANE PROTEIN
2jin  MEMBRANE PROTEIN
2jxo  PROTEIN BINDING
2ogp  SIGNALING PROTEIN
2omj  CELL ADHESION
2oqs  PEPTIDE-BINDING PROTEIN
2os6  CELL ADHESION
2ozf  PROTEIN BINDING
2pnt  STRUCTURAL GENOMICS, UNKNOWN FUNCTION
2q9v  TRANSFERASE
2r4h  TRANSFERASE
2v90  PROTEIN-BINDING
2vz5  PROTEIN BINDING
2w4f  STRUCTURAL PROTEIN
2yuy  SIGNALING PROTEIN
2z0q  SIGNALING PROTEIN
3b76  LIGASE
3cx6  SIGNALING PROTEIN
3cx7  SIGNALING PROTEIN
3cx8  SIGNALING PROTEIN
3diw  SIGNALING PROTEIN/CELL ADHESION
3dj1  SIGNALING PROTEIN
3dj3  SIGNALING PROTEIN
3eo2  SPLICING
3pdz  HYDROLASE

PSSH:
ID  Description
Q6P526  UNKNOWN
Q9NZN5  UNKNOWN

Diseases
OMIM:
OMIM ID  Name  Alt Name
604763  RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 12; ARHGEF12   RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR, LEUKEMIA-ASSOCIATED LEUKEMIA-ASSOCIATED RHO GEF; LARG KIAA0382 LARG/MLL FUSION GENE, INCLUDED

Gene Ontology
GO:
GO ID  Description
GO:0005085  guanyl-nucleotide exchange factor activity
GO:0005089  Rho guanyl-nucleotide exchange factor activity
GO:0005096  GTPase activator activity
GO:0005515  protein binding
GO:0005622  intracellular
GO:0005737  cytoplasm
GO:0007242  intracellular signaling cascade
GO:0016020  membrane
GO:0035023  regulation of Rho protein signal transduction

Pathway
KEGG:
KEGG PATHWAY ID  Name
hsa04360  Axon guidance
hsa04810  Regulation of actin cytoskeleton
hsa04270  Vascular smooth muscle contraction

Panther:
ID  Description

Chemicals
DrugBank:
ID  Name  Synonyms
HMDB:
ID  Name  Synonyms
Orthology
Orthology Relations:
Gene Gene Description Organism Orthology type Orthologs Orthologs Description
ENSG00000196914 Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) [Source:UniProtKB/Swiss-Prot;Acc:Q9NZN5] Rattus_norvegicusone2one ENSRNOG00000008924Rho guanine nucleotide exchange factor (GEF) 12 [Source:RefSeq_peptide;Acc:NP_001013264][hgnc]Arhgef12
Equus_caballusone2one ENSECAG00000022702Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) [Source:UniProtKB/Swiss-Prot;Acc:Q9NZN5][hgnc]
Tupaia_belangerione2one ENSTBEG00000007175Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) [Source:UniProtKB/Swiss-Prot;Acc:Q9NZN5][hgnc]
Mus_musculusone2one ENSMUSG00000059495Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) [Source:UniProtKB/Swiss-Prot;Acc:Q8R4H2][hgnc]639868
Cavia_porcellusone2one ENSCPOG00000010479Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) [Source:UniProtKB/Swiss-Prot;Acc:Q9NZN5][hgnc]
Tarsius_syrichtaone2one ENSTSYG00000001229Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) [Source:UniProtKB/Swiss-Prot;Acc:Q9NZN5][hgnc]
Microcebus_murinusone2one ENSMICG00000011152Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) [Source:UniProtKB/Swiss-Prot;Acc:Q9NZN5][hgnc]
Sorex_araneusone2one ENSSARG00000003515Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) [Source:UniProtKB/Swiss-Prot;Acc:Q9NZN5][hgnc]
Bos_taurusone2one ENSBTAG00000021343Guanine nucleotide exchange factor. [Source:UniProtKB/TrEMBL;Acc:Q5DWF9][hgnc]ARHGEF12
Myotis_lucifugusone2one ENSMLUG00000003285Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) [Source:UniProtKB/Swiss-Prot;Acc:Q9NZN5][hgnc]
Canis_familiarisone2one ENSCAFG00000011934Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) [Source:UniProtKB/Swiss-Prot;Acc:Q9NZN5][hgnc]ARHGEF12
Tursiops_truncatusone2one ENSTTRG00000011693Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) [Source:UniProtKB/Swiss-Prot;Acc:Q9NZN5][hgnc]
Pteropus_vampyrusone2one ENSPVAG00000011807Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) [Source:UniProtKB/Swiss-Prot;Acc:Q9NZN5][hgnc]
Otolemur_garnettiione2one ENSOGAG00000010533Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) [Source:UniProtKB/Swiss-Prot;Acc:Q9NZN5][hgnc]
Dasypus_novemcinctusone2one ENSDNOG00000000591Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) [Source:UniProtKB/Swiss-Prot;Acc:Q9NZN5][hgnc]
Ochotona_princepsone2one ENSOPRG00000005412Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) [Source:UniProtKB/Swiss-Prot;Acc:Q9NZN5][hgnc]
Oryctolagus_cuniculusone2one ENSOCUG00000005196Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) [Source:UniProtKB/Swiss-Prot;Acc:Q9NZN5][hgnc]
Spermophilus_tridecemlineatusone2one ENSSTOG00000015856Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) [Source:UniProtKB/Swiss-Prot;Acc:Q9NZN5][hgnc]
Vicugna_pacosone2one ENSVPAG00000010279Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) [Source:UniProtKB/Swiss-Prot;Acc:Q9NZN5][hgnc]
Monodelphis_domesticaone2one ENSMODG00000013134Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) [Source:UniProtKB/Swiss-Prot;Acc:Q9NZN5][hgnc]
Procavia_capensisone2one ENSPCAG00000003051Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) [Source:UniProtKB/Swiss-Prot;Acc:Q9NZN5][hgnc]
Pongo_pygmaeusone2one ENSPPYG00000003974Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) [Source:UniProtKB/Swiss-Prot;Acc:Q9NZN5][hgnc]
Pan_troglodytesone2one ENSPTRG00000004393Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) [Source:UniProtKB/Swiss-Prot;Acc:Q9NZN5][hgnc]ARHGEF12
Danio_rerioone2one ENSDARG00000030532Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) [Source:UniProtKB/Swiss-Prot;Acc:Q9NZN5][hgnc]
Tetraodon_nigroviridisone2many ENSTNIG00000007786Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) [Source:UniProtKB/Swiss-Prot;Acc:Q9NZN5][hgnc]
Takifugu_rubripesone2many ENSTRUG00000014895Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) [Source:UniProtKB/Swiss-Prot;Acc:Q9NZN5][hgnc]
Loxodonta_africanaone2one ENSLAFG00000013288Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) [Source:UniProtKB/Swiss-Prot;Acc:Q9NZN5][hgnc]
Echinops_telfairione2one ENSETEG00000000237Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) [Source:UniProtKB/Swiss-Prot;Acc:Q9NZN5][hgnc]
Dipodomys_ordiione2one ENSDORG00000007308Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) [Source:UniProtKB/Swiss-Prot;Acc:Q8R4H2][hgnc]
Erinaceus_europaeusone2one ENSEEUG00000011770Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) [Source:UniProtKB/Swiss-Prot;Acc:Q9NZN5][hgnc]
Xenopus_tropicalisone2one ENSXETG00000017018Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) [Source:UniProtKB/Swiss-Prot;Acc:Q9NZN5][hgnc]
Gallus_gallusone2one ENSGALG00000006663Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) [Source:UniProtKB/Swiss-Prot;Acc:Q9NZN5][hgnc]ARHGEF12
Ciona_savignyione2many ENSCSAVG00000003345[hgnc]
Ciona_intestinalisone2many ENSCING00000007425[hgnc]
Ornithorhynchus_anatinusone2one ENSOANG00000006268Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) [Source:UniProtKB/Swiss-Prot;Acc:Q9NZN5][hgnc]100073922
Tetraodon_nigroviridisone2many ENSTNIG00000010274Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) [Source:UniProtKB/Swiss-Prot;Acc:Q9NZN5][hgnc]
Takifugu_rubripesone2many ENSTRUG00000011716Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) [Source:UniProtKB/Swiss-Prot;Acc:Q9NZN5][hgnc]