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Summary sheet information for Effector 'GRK6-Homo sapiens'
Name GRK6-Homo sapiens
Description RecName: Full=G protein-coupled receptor kinase 6; EC=2.7.11.16;AltName: Full=G protein-coupled receptor kinase GRK6
Class
Family Ser Thr protein kinases
Sub_family G protein coupled receptor kinases
type GRK6
Protein features link Protein Information from Dasty2 DAS Client
GPCR, G-protein, Effector interaction Visualizaton of GPCR, G-protein, Effector interaction at protein level
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Genes
Gene Location:
Chromosome: 5
Gene Start: 176786293
Gene End: 176802456
Ensembl Contig View

Ensembl Genes:
ENSG00000198055

EMBL:
EMBL ID  Description
AF040751  Homo sapiens G protein-coupled receptor kinase 6, splice variant B (GRK6) mRNA, complete cds.
AF040752  Homo sapiens G protein-coupled receptor kinase 6, splice variant C (GRK6) mRNA, complete cds.
BC009277  Homo sapiens G protein-coupled receptor kinase 6, mRNA (cDNA clone MGC:10490 IMAGE:4053197), complete cds.
BC017272  Homo sapiens G protein-coupled receptor kinase 6, mRNA (cDNA clone MGC:29578 IMAGE:4640283), complete cds.
L16862  Homo sapiens G protein-coupled receptor kinase (GRK6) mRNA, complete cds.
U00686  Human putative novel receptor kinase (GPRKG) gene, partial cds.

EntrezGene:
ID  Description
GRK6  G protein-coupled receptor kinase 6

RefSeq DNA:
ID  Description
NM_001004105  Homo sapiens G protein-coupled receptor kinase 6 (GRK6), transcript variant 3, mRNA.
NM_001004106  Homo sapiens G protein-coupled receptor kinase 6 (GRK6), transcript variant 1, mRNA.
NM_002082  Homo sapiens G protein-coupled receptor kinase 6 (GRK6), transcript variant 2, mRNA.

UniGene:
ID  Description
Hs.235116  G protein-coupled receptor kinase 6, splice variant C (GRK6)
Hs.609613  Transcribed locus

Proteins
Ensembl Proteins:
ENSP00000348230; ENSP00000347655; ENSP00000377204

Entrez Proteins:
AAA03565.1; AAA60175.1; AAC09273.1; AAC09274.1; AAH09277.1; AAH17272.1

RefSeq Proteins:
ID  Description
NP_001004105  G protein-coupled receptor kinase 6 isoform C [Homo sapiens].
NP_001004106  G protein-coupled receptor kinase 6 isoform A [Homo sapiens].
NP_002073  G protein-coupled receptor kinase 6 isoform B [Homo sapiens].

UniProt:
ID  Description
P43250-2  UNKNOWN
Q96AD6  SubName: Full=G protein-coupled receptor kinase 6;
P43250  RecName: Full=G protein-coupled receptor kinase 6; EC=2.7.11.16; AltName: Full=G protein-coupled receptor kinase GRK6;

Domains
SMART:
- Hyperlink to SMART; - Hyperlink to ENSEMBL

InterPro:
ID  Name
IPR008271  Ser_thr_pkin_AS
IPR002290  Ser_thr_pkinase
IPR000342  Regulat_G_prot_signal
IPR000961  Pkinase_C
IPR017441  Protein_kinase_ATP_bd_CS
IPR017442  Se/Thr_pkinase-rel
IPR000239  GPCR_kinase
IPR000719  Prot_kinase_core

Pfam:
ID  Description
Pkinase  Protein kinase domain
RGS  Regulator of G protein signaling domain

Structure
PDB:
ID
2ACX

HSSP:
ID  Description
1gzk  KINASE
1gzn  KINASE
1gzo  KINASE
1mrv  TRANSFERASE
1mry  TRANSFERASE
1o6k  TRANSFERASE
1o6l  TRANSFERASE
1omw  TRANSFERASE
1vzo  TRANSFERASE
1xjd  TRANSFERASE
1ym7  TRANSFERASE
1zrz  TRANSFERASE
2acx  TRANSFERASE
2bcj  TRANSFERASE/HYDROLASE
2buj  TRANSFERASE
2i0e  TRANSFERASE
2jdo  TRANSFERASE
2jdr  TRANSFERASE
2jed  TRANSFERASE
2uw9  TRANSFERASE/INHIBITOR COMPLEX
2z7q  TRANSFERASE
2z7r  TRANSFERASE
2z7s  TRANSFERASE
3c4w  TRANSFERASE
3c4x  TRANSFERASE
3c4y  TRANSFERASE
3c4z  TRANSFERASE
3c50  TRANSFERASE
3c51  TRANSFERASE
3cqu  TRANSFERASE
3cqw  TRANSFERASE
3d0e  TRANSFERASE INHIBITOR
3e87  TRANSFERASE
3e88  TRANSFERASE
3e8d  TRANSFERASE

PSSH:
ID  Description
Q96AD6  UNKNOWN
P43250  UNKNOWN

Diseases
OMIM:
OMIM ID  Name  Alt Name
600869  G PROTEIN-COUPLED RECEPTOR KINASE 6; GPRK6   GRK6

Gene Ontology
GO:
GO ID  Description
GO:0000166  nucleotide binding
GO:0004672  protein kinase activity
GO:0004674  protein serine/threonine kinase activity
GO:0004703  G-protein coupled receptor kinase activity
GO:0004713  protein tyrosine kinase activity
GO:0004871  signal transducer activity
GO:0005524  ATP binding
GO:0006468  protein amino acid phosphorylation
GO:0007165  signal transduction
GO:0008277  regulation of G-protein coupled receptor protein signaling pathway
GO:0016020  membrane
GO:0016740  transferase activity

Pathway
KEGG:
KEGG PATHWAY ID  Name
hsa04062  Chemokine signaling pathway
hsa04144  Endocytosis

Panther:
ID  Description
P05911  Angiotensin II-stimulated signaling through G proteins and beta-arrestin
P00026  Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
P00031  Inflammation mediated by chemokine and cytokine signaling pathway

Chemicals
DrugBank:
ID  Name  Synonyms
HMDB:
ID  Name  Synonyms
Orthology
Orthology Relations:
Gene Gene Description Organism Orthology type Orthologs Orthologs Description
ENSG00000198055 G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6) [Source:UniProtKB/Swiss-Prot;Acc:P43250] Pan_troglodytesone2one ENSPTRG00000017584G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6) [Source:UniProtKB/Swiss-Prot;Acc:P43250][hgnc]GRK6
Pongo_pygmaeusone2one ENSPPYG00000016092G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6) [Source:UniProtKB/Swiss-Prot;Acc:P43250][hgnc]
Macaca_mulattaone2one ENSMMUG00000019817G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6) [Source:UniProtKB/Swiss-Prot;Acc:P43250][hgnc]
Equus_caballusone2one ENSECAG00000019815G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6) [Source:UniProtKB/Swiss-Prot;Acc:P43250][hgnc]LOC100068570
Tupaia_belangerione2one ENSTBEG00000015913G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6) [Source:UniProtKB/Swiss-Prot;Acc:P43250][hgnc]
Oryctolagus_cuniculusone2one ENSOCUG00000005920G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6) [Source:UniProtKB/Swiss-Prot;Acc:P43250][hgnc]
Myotis_lucifugusone2one ENSMLUG00000004269G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6) [Source:UniProtKB/Swiss-Prot;Acc:P43250][hgnc]
Pteropus_vampyrusone2one ENSPVAG00000013884G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6) [Source:UniProtKB/Swiss-Prot;Acc:P43250][hgnc]
Tursiops_truncatusone2one ENSTTRG00000009577G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6) [Source:UniProtKB/Swiss-Prot;Acc:P43250][hgnc]
Canis_familiarisone2one ENSCAFG00000016388G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6) [Source:UniProtKB/Swiss-Prot;Acc:P43250][hgnc]
Felis_catusone2one ENSFCAG00000001539G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6) [Source:UniProtKB/Swiss-Prot;Acc:P43250][hgnc]
Microcebus_murinusone2one ENSMICG00000012126G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6) [Source:UniProtKB/Swiss-Prot;Acc:P43250][hgnc]
Dasypus_novemcinctusone2one ENSDNOG00000002890G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6) [Source:UniProtKB/Swiss-Prot;Acc:P43250][hgnc]
Echinops_telfairione2one ENSETEG00000002384G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6) [Source:UniProtKB/Swiss-Prot;Acc:P43250][hgnc]
Vicugna_pacosone2one ENSVPAG00000006682G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6) [Source:UniProtKB/Swiss-Prot;Acc:P43250][hgnc]
Loxodonta_africanaone2one ENSLAFG00000010583G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6) [Source:UniProtKB/Swiss-Prot;Acc:P43250][hgnc]
Procavia_capensisone2one ENSPCAG00000009003G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6) [Source:UniProtKB/Swiss-Prot;Acc:P43250][hgnc]
Cavia_porcellusone2one ENSCPOG00000004047G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6) [Source:UniProtKB/Swiss-Prot;Acc:P43250][hgnc]
Spermophilus_tridecemlineatusone2one ENSSTOG00000008405G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6) [Source:UniProtKB/Swiss-Prot;Acc:P43250][hgnc]
Otolemur_garnettiione2one ENSOGAG00000006547G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6) [Source:UniProtKB/Swiss-Prot;Acc:P43250][hgnc]
Ochotona_princepsone2one ENSOPRG00000002724G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6) [Source:UniProtKB/Swiss-Prot;Acc:P43250][hgnc]
Dipodomys_ordiione2one ENSDORG00000009457G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6) [Source:UniProtKB/Swiss-Prot;Acc:O70293][hgnc]
Rattus_norvegicusone2one ENSRNOG00000014615G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6). [Source:UniProtKB/Swiss-Prot;Acc:P97711][hgnc]Gprk6
Mus_musculusone2one ENSMUSG00000074886G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6) [Source:UniProtKB/Swiss-Prot;Acc:O70293][hgnc]Grk6
Erinaceus_europaeusone2one ENSEEUG00000004113G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6) [Source:UniProtKB/Swiss-Prot;Acc:P43250][hgnc]
Ornithorhynchus_anatinusone2one ENSOANG00000010127G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6) [Source:UniProtKB/Swiss-Prot;Acc:P43250][hgnc]100084380
Monodelphis_domesticaone2one ENSMODG00000004602G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6) [Source:UniProtKB/Swiss-Prot;Acc:P43250][hgnc]
Gallus_gallusone2one ENSGALG00000014054G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6) [Source:UniProtKB/Swiss-Prot;Acc:P43250][hgnc]GRK6
Danio_rerioone2one ENSDARG00000032157[hgnc]LOC561288
Gasterosteus_aculeatusone2one ENSGACG00000020808G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6) [Source:UniProtKB/Swiss-Prot;Acc:P43250][hgnc]
Xenopus_tropicalisone2one ENSXETG00000007243G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6) [Source:UniProtKB/Swiss-Prot;Acc:P43250][hgnc]
Takifugu_rubripesone2one ENSTRUG00000001036G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6) [Source:UniProtKB/Swiss-Prot;Acc:P43250][hgnc]
Tetraodon_nigroviridisone2one ENSTNIG00000007615G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6) [Source:UniProtKB/Swiss-Prot;Acc:P43250][hgnc]
Oryzias_latipesone2one ENSORLG00000018337G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6) [Source:UniProtKB/Swiss-Prot;Acc:P43250][hgnc]
Ciona_intestinalisone2many ENSCING00000003418[hgnc]
Ciona_savignyione2many ENSCSAVG00000011388[hgnc]
Drosophila_melanogasterone2many FBgn0004834[hgnc]Gprk2
Anopheles_gambiaeone2many AGAP004117[hgnc]AgaP_ENSANGG00000017908
Aedes_aegyptione2many AAEL006110g protein-coupled receptor kinase 6 and[hgnc]
Caenorhabditis_elegansone2many F19C6.1grk-1 encodes a serine/threonine protein kinase that is most closely related to G protein-coupled receptor (GPCR) kinases. [Source: WormBase][hgnc]grk-1