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Summary sheet information for Effector 'Voltage dependent R type calcium channel-Homo sapiens'
Name Voltage dependent R type calcium channel-Homo sapiens
Description "RecName: Full=Voltage-dependent R-type calcium channel subunit alpha-1E;AltName: Full=Voltage-gated calcium channel subunit alpha Cav2.3;AltName: Full=Calcium channel, L type, alpha-1 polypeptide, isoform 6;AltName: Full=Brain calcium channel II; Short=BII;"
Class
Family Ion channels
Sub_family Voltage dependent calcium channels
type Voltage dependent R type calcium channel
Protein features link Protein Information from Dasty2 DAS Client
GPCR, G-protein, Effector interaction Visualizaton of GPCR, G-protein, Effector interaction at protein level
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Genes
Gene Location:
Chromosome: 1
Gene Start: 179648918
Gene End: 180037339
Ensembl Contig View

Ensembl Genes:
ENSG00000198216

EMBL:
EMBL ID  Description
AB209499  Homo sapiens mRNA for calcium channel, voltage-dependent, alpha 1E subunit variant protein.
AF152379  Homo sapiens voltage-gated calcium channel alpha 1E subunit (CACNA1E) gene, exons 13 and 14 and partial cds.
AF223391  Homo sapiens calcium channel alpha1E subunit (CACNA1E) gene, exons 7-49, and partial cds, alternatively spliced.
AF239258  Homo sapiens calcium channel alpha1E subunit (CACNA1E) gene, exons 2 and 3.
AF239259  Homo sapiens calcium channel alpha1E subunit (CACNA1E) gene, exons 4, 5, and 6.
AJ276502  Homo sapiens partial CACNA1E gene for voltage-dependent calcium channel alpha 1E subunit, exon 1
AL160059  Human DNA sequence from clone RP11-94G15 on chromosome 1 Contains the 5' end of the CACNA1E gene for calcium channel voltage-dependent alpha 1E subunit.
AL161734  Human DNA sequence from clone RP11-33M22 on chromosome 1q25.2-31.2 Contains the 3' end of the CACNA1E gene for calcium channel voltage-dependent alpha 1E subunit.
AL359270  Human DNA sequence from clone RP11-494J9 on chromosome 1 Contains parrt of the CACNA1E gene for calcium channel voltage-dependent alpha 1E subunit.
AL590998  Human DNA sequence from clone RP4-677A15 on chromosome 1 Contains parrt of the CACNA1E gene for calcium channel voltage-dependent alpha 1E subunit.
L27745  Homo sapiens voltage-operated calcium channel, alpha-1 subunit mRNA, complete cds.
L29384  Homo sapiens (clone pcDNA-alpha1E-1) voltage-dependent calcium channel alpha-1E-1 subunit mRNA, complete cds.
L29385  Homo sapiens (clone pcDNA-alpha1E-3) voltage-dependent calcium channel alpha-1E-3 subunit mRNA, complete cds.

EntrezGene:
ID  Description
CACNA1E  calcium channel, voltage-dependent, R type, alpha 1E subunit

RefSeq DNA:
ID  Description
NM_000721  Homo sapiens calcium channel, voltage-dependent, R type, alpha 1E subunit (CACNA1E), mRNA.

UniGene:
ID  Description
Hs.611396  Gm139

Proteins
Ensembl Proteins:
ENSP00000353222; ENSP00000356542; ENSP00000356545; ENSP00000356539; ENSP00000351101; ENSP00000350183

Entrez Proteins:
AAA59204.1; AAA59205.1; AAA72125.1; AAD38389.1; AAF37687.1; AAF37688.1; BAD92736.1; CAB81554.1; CAH72675.1; CAH72676.1; CAH72677.1; CAI14653.1; CAI14654.1; CAI14655.1; CAI17081.1; CAI17082.1; CAI17083.1; CAI22327.1; CAI22328.1; CAI22329.1

RefSeq Proteins:
ID  Description
NP_000712  calcium channel, voltage-dependent, R type, alpha 1E subunit [Homo sapiens].

UniProt:
ID  Description
Q15878-2  UNKNOWN
Q15878-3  UNKNOWN
B1AM12  SubName: Full=Calcium channel, voltage-dependent, R type, alpha 1E subunit;
B1AM13  SubName: Full=Calcium channel, voltage-dependent, R type, alpha 1E subunit;
B1AM14  UNKNOWN
Q59FG1  SubName: Full=Calcium channel, voltage-dependent, alpha 1E subunit variant; Flags: Fragment;
Q9NY05  SubName: Full=Voltage-dependent calcium channel alpha 1E subunit; Flags: Fragment;
Q9NYZ5  SubName: Full=Calcium channel alpha1E subunit, delta19 delta40 delta46 splice variant; Flags: Fragment;
Q9NYZ6  SubName: Full=Calcium channel alpha1E subunit, delta39 splice variant; Flags: Fragment;
Q9UN68  SubName: Full=Voltage-gated calcium channel alpha 1E subunit; Flags: Fragment;
Q15878  RecName: Full=Voltage-dependent R-type calcium channel subunit alpha-1E; AltName: Full=Voltage-gated calcium channel subunit alpha Cav2.3; AltName: Full=Calcium channel, L type, alpha-1 polypeptide, isoform 6; AltName: Full=Brain calcium channel II; Short=BII;

Domains
SMART:
- Hyperlink to SMART; - Hyperlink to ENSEMBL
     Voltage dependent R type calcium channel-Homo sapiens    

InterPro:
ID  Name
IPR005821  Ion_trans
IPR005449  VDCC_R_a1su
IPR002048  EF_hand_Ca_bd
IPR002077  VDCCAlpha1
IPR014873  VDCC_a1su_IQ

Pfam:
ID  Description
Ion_trans  Ion transport protein
Ion_trans  Ion transport protein
Ca_chan_IQ  Voltage gated calcium channel IQ domain

Structure
PDB:
ID
3BXL

HSSP:
ID  Description
3bxk  MEMBRANE PROTEIN, SIGNALING PROTEIN
3bxl  MEMBRANE PROTEIN, SIGNALING PROTEIN
3dvj  MEMBRANE PROTEIN
3dvk  MEMBRANE PROTEIN
3dvm  MEMBRANE PROTEIN

PSSH:
ID  Description
Q59FG1  UNKNOWN
Q9NYZ5  UNKNOWN
Q9NYZ6  UNKNOWN
Q15878  UNKNOWN

Diseases
OMIM:
OMIM ID  Name  Alt Name
601013  CALCIUM CHANNEL, VOLTAGE-DEPENDENT, ALPHA-1E SUBUNIT; CACNA1E   CALCIUM CHANNEL, L TYPE, ALPHA-1 POLYPEPTIDE, ISOFORM 6; CACNL1A6 CaV2.3 CALCIUM CHANNEL, R TYPE

Gene Ontology
GO:
GO ID  Description
GO:0005216  ion channel activity
GO:0005244  voltage-gated ion channel activity
GO:0005245  voltage-gated calcium channel activity
GO:0005249  voltage-gated potassium channel activity
GO:0005509  calcium ion binding
GO:0005886  plasma membrane
GO:0005891  voltage-gated calcium channel complex
GO:0006811  ion transport
GO:0006813  potassium ion transport
GO:0006816  calcium ion transport
GO:0007268  synaptic transmission
GO:0008076  voltage-gated potassium channel complex
GO:0016020  membrane
GO:0016021  integral to membrane
GO:0042593  glucose homeostasis
GO:0043204  perikaryon
GO:0047485  protein N-terminus binding

Pathway
KEGG:
KEGG PATHWAY ID  Name
hsa04020  Calcium signaling pathway
hsa04010  MAPK signaling pathway
hsa04930  Type II diabetes mellitus

Panther:
ID  Description
P00039  Metabotropic glutamate receptor group III pathway
P04394  Thyrotropin-releasing hormone receptor signaling pathway
P00037  Ionotropic glutamate receptor pathway
P00040  Metabotropic glutamate receptor group II pathway
P00027  Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway

Chemicals
DrugBank:
ID  Name  Synonyms
HMDB:
ID  Name  Synonyms
Orthology
Orthology Relations:
Gene Gene Description Organism Orthology type Orthologs Orthologs Description
ENSG00000198216 Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage-gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) [Source:UniProtKB/Swiss-Prot;Acc:Q15878] Pan_troglodytesone2one ENSPTRG00000001749PREDICTED: Pan troglodytes similar to voltage-dependent calcium channel alpha-1E-3 (LOC457564), mRNA. [Source:RefSeq_dna;Acc:XR_024642][hgnc]LOC457564
Pongo_pygmaeusone2one ENSPPYG00000000442Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage-gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) [Source:UniProtKB/Swiss-Prot;Acc:Q15878][hgnc]
Macaca_mulattaone2one ENSMMUG00000014498Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage-gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) [Source:UniProtKB/Swiss-Prot;Acc:Q15878][hgnc]
Tarsius_syrichtaone2one ENSTSYG00000011774Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage-gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) [Source:UniProtKB/Swiss-Prot;Acc:Q15878][hgnc]
Tursiops_truncatusone2one ENSTTRG00000003504Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage-gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) [Source:UniProtKB/Swiss-Prot;Acc:Q15878][hgnc]
Equus_caballusone2one ENSECAG00000012027Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage-gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) [Source:UniProtKB/Swiss-Prot;Acc:Q15878][hgnc]
Tupaia_belangerione2one ENSTBEG00000015583Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage-gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) [Source:UniProtKB/Swiss-Prot;Acc:Q15878][hgnc]
Microcebus_murinusone2one ENSMICG00000008818Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage-gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) [Source:UniProtKB/Swiss-Prot;Acc:Q15878][hgnc]
Felis_catusone2one ENSFCAG00000015444Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage-gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) [Source:UniProtKB/Swiss-Prot;Acc:Q15878][hgnc]
Cavia_porcellusone2one ENSCPOG00000014861Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage-gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) [Source:UniProtKB/Swiss-Prot;Acc:Q15878][hgnc]
Spermophilus_tridecemlineatusone2one ENSSTOG00000009320Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage-gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) [Source:UniProtKB/Swiss-Prot;Acc:Q15878][hgnc]
Otolemur_garnettiione2one ENSOGAG00000001113Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage-gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) [Source:UniProtKB/Swiss-Prot;Acc:Q15878][hgnc]
Procavia_capensisone2one ENSPCAG00000009916Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage-gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) [Source:UniProtKB/Swiss-Prot;Acc:Q15878][hgnc]
Dipodomys_ordiione2one ENSDORG00000001636Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage-gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) [Source:UniProtKB/Swiss-Prot;Acc:Q61290][hgnc]
Pteropus_vampyrusone2one ENSPVAG00000004068Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage-gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) [Source:UniProtKB/Swiss-Prot;Acc:Q15878][hgnc]
Vicugna_pacosone2one ENSVPAG00000000697Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage-gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) [Source:UniProtKB/Swiss-Prot;Acc:Q15878][hgnc]
Mus_musculusone2one ENSMUSG00000004110Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage-gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) [Source:UniProtKB/Swiss-Prot;Acc:Q61290][hgnc]Cacna1e
Rattus_norvegicusone2one ENSRNOG00000002863Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage- gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (RBE-II) (RBE2) (Brain calcium channel II) (BII). [Source:UniProtKB/Swiss-Prot;Acc:Q07652][hgnc]Cacna1e
Myotis_lucifugusone2one ENSMLUG00000017464Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage-gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) [Source:UniProtKB/Swiss-Prot;Acc:Q15878][hgnc]
Echinops_telfairione2one ENSETEG00000000110Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage-gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) [Source:UniProtKB/Swiss-Prot;Acc:Q15878][hgnc]
Erinaceus_europaeusone2one ENSEEUG00000003927Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage-gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) [Source:UniProtKB/Swiss-Prot;Acc:Q15878][hgnc]
Loxodonta_africanaone2one ENSLAFG00000009241Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage-gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) [Source:UniProtKB/Swiss-Prot;Acc:Q15878][hgnc]
Ochotona_princepsone2one ENSOPRG00000005674Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage-gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) [Source:UniProtKB/Swiss-Prot;Acc:Q15878][hgnc]
Oryctolagus_cuniculusone2one ENSOCUG00000017547Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage-gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) [Source:UniProtKB/Swiss-Prot;Acc:Q15878][hgnc]
Ornithorhynchus_anatinusone2one ENSOANG00000000975Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage-gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) [Source:UniProtKB/Swiss-Prot;Acc:Q15878][hgnc]
Monodelphis_domesticaone2one ENSMODG00000006729Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage-gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) [Source:UniProtKB/Swiss-Prot;Acc:Q15878][hgnc]
Gallus_gallusone2one ENSGALG00000003833Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage-gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) [Source:UniProtKB/Swiss-Prot;Acc:Q15878][hgnc]
Canis_familiarisone2one ENSCAFG00000013004Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage-gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) [Source:UniProtKB/Swiss-Prot;Acc:Q15878][hgnc]
Xenopus_tropicalisone2one ENSXETG00000012458Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage-gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) [Source:UniProtKB/Swiss-Prot;Acc:Q15878][hgnc]
Danio_rerioapprent_one2one ENSDARG00000062346Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage-gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) [Source:UniProtKB/Swiss-Prot;Acc:Q15878][hgnc]
Oryzias_latipesone2one ENSORLG00000011019Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage-gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) [Source:UniProtKB/Swiss-Prot;Acc:Q15878][hgnc]