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Summary sheet information for GPCR 'GONADOTROPIN-RELEASING HORMONE RECEPTORS_GNRH2_Homo sapiens'
Name GONADOTROPIN-RELEASING HORMONE RECEPTORS_GNRH2_Homo sapiens
Description RecName: Full=Putative gonadotropin-releasing hormone II receptor;AltName: Full=Type II GnRH receptor;AltName: Full=GnRH-II-R
Class CLASS A
Family GONADOTROPIN-RELEASING HORMONE RECEPTORS
Sub_family GNRH2
type
Protein features link Protein Information from Dasty2 DAS Client
GPCR, G-protein, Effector interaction Visualizaton of GPCR, G-protein, Effector interaction at protein level
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Genes
Gene Location:
Chromosome: 1
Gene Start: 144221109
Gene End: 144227433
Ensembl Contig View

Ensembl Genes:
ENSG00000211451

EMBL:
EMBL ID  Description
AB239331  Homo sapiens GnRHRII mRNA for type II gonadotropin-releasing hormone receptor fragment, complete cds.
AF403014  Homo sapiens type II gonadotropin-releasing hormone receptor gene, partial cds.
AL160282  Human DNA sequence from clone RP11-315I20 on chromosome 1q12.1-21.3 Contains the 3' end of the TXNIP gene for thioredoxin interacting protein, four novel genes, the gene for a novel protein similar to mouse limb expression 1 homolog (chicken) Lix1, the RBM8A gene for RNA binding motif protein 8A, a gonadotropin-releasing hormone 2 (GNRH2) pseudogene, the PEX11B gene for peroxisomal biogenesis factor 11B, the ITGA10 gene for integrin alpha 10, the gene for protein inhibitor of activated STAT3 PIAS3, the gene for polymerase (RNA) III (DNA directed) (62kD) RPC62, the 5' end of the ZNF364 gene for zinc finger protein 364 and two CpG islands.
AY081843  Homo sapiens GnRH receptor II 5TM mRNA, complete cds.
AY233133  Homo sapiens GnRH receptor II precursor RNA, complete cds.
DQ266410  Homo sapiens type II gonadotropin-releasing hormone receptor splice variant (GNRHR2) mRNA, complete cds, alternatively spliced.

EntrezGene:
ID  Description

RefSeq DNA:
ID  Description

UniGene:
ID  Description

Proteins
Ensembl Proteins:
ENSP00000345043; ENSP00000320895; ENSP00000354569

Entrez Proteins:
AAL27000.1; AAL89821.1; AAP74658.1; ABB82942.1; BAF35581.1

RefSeq Proteins:
ID  Description

UniProt:
ID  Description
Q96P88-2  UNKNOWN
A6NDW2  SubName: Full=Putative uncharacterized protein GNRHR2;
Q2MZ38  SubName: Full=Type II gonadotropin-releasing hormone receptor; SubName: Full=Type II gonadotropin-releasing hormone receptor splice variant; SubName: Full=Putative uncharacterized protein GNRHR2;
Q6XGY1  SubName: Full=GnRH receptor II;
Q96P88  RecName: Full=Putative gonadotropin-releasing hormone II receptor; AltName: Full=Type II GnRH receptor; AltName: Full=GnRH-II-R;

Domains
SMART:
- Hyperlink to SMART; - Hyperlink to ENSEMBL

InterPro:
ID  Name
IPR017452  GPCR_Rhodpsn_supfam
IPR000276  GPCR_Rhodpsn
IPR001658  GphnRH_rcpt

Pfam:
ID  Description
7tm_1  7 transmembrane receptor (rhodopsin family)

Structure
PDB:
ID

HSSP:
ID  Description

PSSH:
ID  Description

Diseases
OMIM:
OMIM ID  Name  Alt Name

Gene Ontology
GO:
GO ID  Description
GO:0001584  rhodopsin-like receptor activity
GO:0004872  receptor activity
GO:0004968  gonadotropin-releasing hormone receptor activity
GO:0005886  plasma membrane
GO:0007165  signal transduction
GO:0007186  G-protein coupled receptor protein signaling pathway
GO:0016021  integral to membrane

Pathway
KEGG:
KEGG PATHWAY ID  Name

Panther:
ID  Description
P00026  Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
P00027  Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway

Chemicals
DrugBank:
ID  Name  Synonyms
DB00644  Gonadorelin  
DB00666  Nafarelin  Nafarelin acetate
DB01406  Danazol  
HMDB:
ID  Name  Synonyms
Other GPCR resources
Links to other GPCR resources
GPCRDB | GPCR-OKB | GLIDA
Orthology
Orthology Relations:
Gene Gene Description Organism Orthology type Orthologs Orthologs Description
ENSG00000211451 Putative gonadotropin-releasing hormone II receptor (Type II GnRH receptor) (GnRH-II-R) [Source:UniProtKB/Swiss-Prot;Acc:Q96P88] Pan_troglodytesone2one ENSPTRG00000001202Putative gonadotropin-releasing hormone II receptor (Type II GnRH receptor) (GnRH-II-R) [Source:UniProtKB/Swiss-Prot;Acc:Q96P88][hgnc]
Macaca_mulattaone2one ENSMMUG00000016049Gonadotropin-releasing hormone II receptor (Type II GnRH receptor) (GnRH-II-R). [Source:UniProtKB/Swiss-Prot;Acc:Q95JG1][hgnc]574163
Pongo_pygmaeusone2one ENSPPYG00000000930Putative gonadotropin-releasing hormone II receptor (Type II GnRH receptor) (GnRH-II-R) [Source:UniProtKB/Swiss-Prot;Acc:Q96P88][hgnc]
Tarsius_syrichtaone2one ENSTSYG00000000907Putative gonadotropin-releasing hormone II receptor (Type II GnRH receptor) (GnRH-II-R) [Source:UniProtKB/Swiss-Prot;Acc:Q96P88][hgnc]
Equus_caballusone2one ENSECAG00000023497Putative gonadotropin-releasing hormone II receptor (Type II GnRH receptor) (GnRH-II-R) [Source:UniProtKB/Swiss-Prot;Acc:Q96P88][hgnc]
Loxodonta_africanaone2many ENSLAFG00000016093[hgnc]
Tursiops_truncatusone2one ENSTTRG00000009117Putative gonadotropin-releasing hormone II receptor (Type II GnRH receptor) (GnRH-II-R) [Source:UniProtKB/Swiss-Prot;Acc:Q96P88][hgnc]
Tupaia_belangerione2one ENSTBEG00000014981Putative gonadotropin-releasing hormone II receptor (Type II GnRH receptor) (GnRH-II-R) [Source:UniProtKB/Swiss-Prot;Acc:Q96P88][hgnc]
Erinaceus_europaeusone2one ENSEEUG00000008848Putative gonadotropin-releasing hormone II receptor (Type II GnRH receptor) (GnRH-II-R) [Source:UniProtKB/Swiss-Prot;Acc:Q96P88][hgnc]
Dipodomys_ordiione2one ENSDORG00000004224[hgnc]
Spermophilus_tridecemlineatusone2one ENSSTOG00000013923Putative gonadotropin-releasing hormone II receptor (Type II GnRH receptor) (GnRH-II-R) [Source:UniProtKB/Swiss-Prot;Acc:Q96P88][hgnc]
Felis_catusone2one ENSFCAG00000005413Putative gonadotropin-releasing hormone II receptor (Type II GnRH receptor) (GnRH-II-R) [Source:UniProtKB/Swiss-Prot;Acc:Q96P88][hgnc]
Loxodonta_africanaone2many ENSLAFG00000011033[hgnc]
Bos_taurusone2one ENSBTAG00000008370Putative gonadotropin-releasing hormone II receptor (Type II GnRH receptor) (GnRH-II-R) [Source:UniProtKB/Swiss-Prot;Acc:Q96P88][hgnc]
Sorex_araneusone2one ENSSARG00000013301Putative gonadotropin-releasing hormone II receptor (Type II GnRH receptor) (GnRH-II-R) [Source:UniProtKB/Swiss-Prot;Acc:Q96P88][hgnc]
Oryctolagus_cuniculusone2one ENSOCUG00000003022Putative gonadotropin-releasing hormone II receptor (Type II GnRH receptor) (GnRH-II-R) [Source:UniProtKB/Swiss-Prot;Acc:Q96P88][hgnc]
Echinops_telfairione2one ENSETEG00000017936Putative gonadotropin-releasing hormone II receptor (Type II GnRH receptor) (GnRH-II-R) [Source:UniProtKB/Swiss-Prot;Acc:Q96P88][hgnc]
Pteropus_vampyrusone2one ENSPVAG00000014473Putative gonadotropin-releasing hormone II receptor (Type II GnRH receptor) (GnRH-II-R) [Source:UniProtKB/Swiss-Prot;Acc:Q96P88][hgnc]
Monodelphis_domesticaone2one ENSMODG00000018751Putative gonadotropin-releasing hormone II receptor (Type II GnRH receptor) (GnRH-II-R) [Source:UniProtKB/Swiss-Prot;Acc:Q96P88][hgnc]
Procavia_capensisone2one ENSPCAG00000014382Putative gonadotropin-releasing hormone II receptor (Type II GnRH receptor) (GnRH-II-R) [Source:UniProtKB/Swiss-Prot;Acc:Q96P88][hgnc]
Xenopus_tropicalisone2one ENSXETG00000016612Putative gonadotropin-releasing hormone II receptor (Type II GnRH receptor) (GnRH-II-R) [Source:UniProtKB/Swiss-Prot;Acc:Q96P88][hgnc]
Gallus_gallusapprent_one2one ENSGALG00000020923gonadotropin-releasing hormone receptor [Source:RefSeq_peptide;Acc:NP_001012627][hgnc]GNRHR