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Summary sheet information for GPCR 'LEUKOTRIENE RECEPTORS_BLT1_Homo sapiens'
Name LEUKOTRIENE RECEPTORS_BLT1_Homo sapiens
Description RecName: Full=Leukotriene B4 receptor 1; Short=LTB4-R 1;AltName: Full=P2Y purinoceptor 7; Short=P2Y7;AltName: Full=Chemoattractant receptor-like 1;AltName: Full=G-protein coupled receptor 16
Class CLASS A
Family LEUKOTRIENE RECEPTORS
Sub_family BLT1
type
Protein features link Protein Information from Dasty2 DAS Client
GPCR, G-protein, Effector interaction Visualizaton of GPCR, G-protein, Effector interaction at protein level
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Genes
Gene Location:
Chromosome: 14
Gene Start: 23850545
Gene End: 23857082
Ensembl Contig View

Ensembl Genes:
ENSG00000213903

EMBL:
EMBL ID  Description
AB008193  Homo sapiens genes for leukotriene B4 receptor BLT2, leukotriene B4 receptor BLT1, complete cds.
AY322535  Homo sapiens leukotriene B4 receptor gene, complete cds.
BC004545  Homo sapiens leukotriene B4 receptor, mRNA (cDNA clone MGC:10388 IMAGE:3946189), complete cds.
BT007267  Homo sapiens leukotriene B4 receptor mRNA, complete cds.
D89078  Homo sapiens mRNA for leukotriene b4 receptor, complete cds.
D89079  Homo sapiens mRNA for leukotriene b4 receptor, complete cds.
U33448  Human putative G-protein-coupled receptor (GPR16) gene, complete cds.
U41070  Human P2 purinergic receptor mRNA, complete cds.
X98356  H.sapiens mRNA for G protein-coupled receptor

EntrezGene:
ID  Description
LTB4R  leukotriene B4 receptor

RefSeq DNA:
ID  Description
NM_181657  Homo sapiens leukotriene B4 receptor (LTB4R), transcript variant 1, mRNA.

UniGene:
ID  Description
Hs.567248  Transcribed locus
Hs.655431  Leukotriene b4 receptor
Hs.679769  Transcribed locus, strongly similar to XP_001114016.1 PREDICTED: leukotriene B4 receptor isoform 1 [Macaca mulatta]

Proteins
Ensembl Proteins:
ENSP00000380002; ENSP00000307445; ENSP00000380008

Entrez Proteins:
AAB16747.1; AAC50628.1; AAH04545.1; AAP35931.1; AAP84348.1; BAA20423.1; BAA20424.1; BAB00611.1; CAA67001.1

RefSeq Proteins:
ID  Description
NP_858043  leukotriene B4 receptor [Homo sapiens].

UniProt:
ID  Description
Q53XV5  SubName: Full=Leukotriene B4 receptor;
Q15722  RecName: Full=Leukotriene B4 receptor 1; Short=LTB4-R 1; AltName: Full=P2Y purinoceptor 7; Short=P2Y7; AltName: Full=Chemoattractant receptor-like 1; AltName: Full=G-protein coupled receptor 16;

Domains
SMART:
- Hyperlink to SMART; - Hyperlink to ENSEMBL

InterPro:
ID  Name
IPR003981  LTB4_rcpt
IPR017452  GPCR_Rhodpsn_supfam
IPR000276  GPCR_Rhodpsn
IPR003983  LTB4_t1_rcpt

Pfam:
ID  Description
7tm_1  7 transmembrane receptor (rhodopsin family)

Structure
PDB:
ID

HSSP:
ID  Description

PSSH:
ID  Description
Q53XV5  UNKNOWN
Q15722  UNKNOWN

Diseases
OMIM:
OMIM ID  Name  Alt Name
601531  LEUKOTRIENE B4 RECEPTOR; LTB4R   LTB4R1 CHEMOKINE RECEPTOR-LIKE 1; CMKRL1 PURINERGIC RECEPTOR P2Y, G PROTEIN-COUPLED, 7; P2RY7 PURINOCEPTOR P2Y7; P2Y7 LEUKOTRIENE B4 G PROTEIN-COUPLED RECEPTOR; BLTR BLT1 G PROTEIN-COUPLED RECEPTOR 16; GPR16

Gene Ontology
GO:
GO ID  Description
GO:0000166  nucleotide binding
GO:0001584  rhodopsin-like receptor activity
GO:0001632  leukotriene B4 receptor activity
GO:0004872  receptor activity
GO:0004945  angiotensin type II receptor activity
GO:0004966  galanin receptor activity
GO:0004974  leukotriene receptor activity
GO:0004982  N-formyl peptide receptor activity
GO:0005886  plasma membrane
GO:0005887  integral to plasma membrane
GO:0006928  cell motion
GO:0006936  muscle contraction
GO:0006954  inflammatory response
GO:0006955  immune response
GO:0007165  signal transduction
GO:0007186  G-protein coupled receptor protein signaling pathway
GO:0007200  activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger
GO:0016021  integral to membrane
GO:0045028  purinergic nucleotide receptor activity, G-protein coupled

Pathway
KEGG:
KEGG PATHWAY ID  Name
hsa04080  Neuroactive ligand-receptor interaction

Panther:
ID  Description

Chemicals
DrugBank:
ID  Name  Synonyms
HMDB:
ID  Name  Synonyms
Other GPCR resources
Links to other GPCR resources
GPCRDB | GPCR-OKB | GLIDA
Orthology
Orthology Relations:
Gene Gene Description Organism Orthology type Orthologs Orthologs Description
ENSG00000213903 Leukotriene B4 receptor 1 (LTB4-R 1) (P2Y purinoceptor 7) (P2Y7) (Chemoattractant receptor-like 1) (G-protein coupled receptor 16) [Source:UniProtKB/Swiss-Prot;Acc:Q15722] Pan_troglodytesone2one ENSPTRG00000006215Leukotriene B4 receptor 1 (LTB4-R 1) (P2Y purinoceptor 7) (P2Y7) (Chemoattractant receptor-like 1) (G-protein coupled receptor 16) [Source:UniProtKB/Swiss-Prot;Acc:Q15722][hgnc]LTB4R
Pongo_pygmaeusone2one ENSPPYG00000005701Leukotriene B4 receptor 1 (LTB4-R 1) (P2Y purinoceptor 7) (P2Y7) (Chemoattractant receptor-like 1) (G-protein coupled receptor 16) [Source:UniProtKB/Swiss-Prot;Acc:Q15722][hgnc]
Macaca_mulattaone2one ENSMMUG00000020697Leukotriene B4 receptor 1 (LTB4-R 1) (P2Y purinoceptor 7) (P2Y7) (Chemoattractant receptor-like 1) (G-protein coupled receptor 16) [Source:UniProtKB/Swiss-Prot;Acc:Q15722][hgnc]
Tarsius_syrichtaone2one ENSTSYG00000014217Leukotriene B4 receptor 1 (LTB4-R 1) (P2Y purinoceptor 7) (P2Y7) (Chemoattractant receptor-like 1) (G-protein coupled receptor 16) [Source:UniProtKB/Swiss-Prot;Acc:Q15722][hgnc]
Equus_caballusone2one ENSECAG00000004228Leukotriene B4 receptor 1 (LTB4-R 1) (P2Y purinoceptor 7) (P2Y7) (Chemoattractant receptor-like 1) (G-protein coupled receptor 16) [Source:UniProtKB/Swiss-Prot;Acc:Q15722][hgnc]LOC100051017
Bos_taurusone2one ENSBTAG00000010238Leukotriene B4 receptor 1 (LTB4-R 1). [Source:UniProtKB/Swiss-Prot;Acc:Q3T181][hgnc]LTB4R
Rattus_norvegicusone2one ENSRNOG00000020399Leukotriene B4 receptor 1 (LTB4-R 1). [Source:UniProtKB/Swiss-Prot;Acc:Q9R0Q2][hgnc]Ltb4r
Mus_musculusone2one ENSMUSG00000046908Leukotriene B4 receptor 1 (LTB4-R 1) [Source:UniProtKB/Swiss-Prot;Acc:O88855][hgnc]Ltb4r1
Cavia_porcellusone2one ENSCPOG00000014410LTB4 receptor (Leukotriene B4 receptor). [Source:UniProtKB/TrEMBL;Acc:Q9WTK1][hgnc]
Monodelphis_domesticaone2one ENSMODG00000003043Leukotriene B4 receptor 1 (LTB4-R 1) (P2Y purinoceptor 7) (P2Y7) (Chemoattractant receptor-like 1) (G-protein coupled receptor 16) [Source:UniProtKB/Swiss-Prot;Acc:Q15722][hgnc]
Ornithorhynchus_anatinusone2one ENSOANG00000015073Leukotriene B4 receptor 1 (LTB4-R 1) (P2Y purinoceptor 7) (P2Y7) (Chemoattractant receptor-like 1) (G-protein coupled receptor 16) [Source:UniProtKB/Swiss-Prot;Acc:Q15722][hgnc]100089776
Xenopus_tropicalisone2many ENSXETG00000017222Leukotriene B4 receptor 1 (LTB4-R 1) (P2Y purinoceptor 7) (P2Y7) (Chemoattractant receptor-like 1) (G-protein coupled receptor 16). [Source:UniProtKB/Swiss-Prot;Acc:Q15722] [from human gene ENSG00000168986][hgnc]
Danio_reriomany2many ENSDARG00000032631[hgnc]LOC566585
Danio_reriomany2many ENSDARG00000061094[hgnc]
Oryzias_latipesmany2many ENSORLG00000018941[hgnc]
Gasterosteus_aculeatusmany2many ENSGACG00000018962[hgnc]
Gasterosteus_aculeatusmany2many ENSGACG00000018954[hgnc]
Tetraodon_nigroviridismany2many ENSTNIG00000007431[hgnc]
Oryzias_latipesmany2many ENSORLG00000018947[hgnc]
Gasterosteus_aculeatusmany2many ENSGACG00000018963[hgnc]
Gasterosteus_aculeatusmany2many ENSGACG00000017812[hgnc]
Tetraodon_nigroviridismany2many ENSTNIG00000007432[hgnc]
Danio_reriomany2many ENSDARG00000067922[hgnc]LOC799131
Danio_reriomany2many ENSDARG00000054170[hgnc]LOC100007528
Takifugu_rubripesone2many ENSTRUG00000006931Leukotriene B4 receptor 2 (LTB4-R2) (Seven transmembrane receptor BLTR2) (Leukotriene B4 receptor BLT2) (LTB4 receptor JULF2) [Source:UniProtKB/Swiss-Prot;Acc:Q9NPC1][hgnc]
Danio_reriomany2many ENSDARG00000053109[hgnc]
Oryzias_latipesmany2many ENSORLG00000002957[hgnc]